HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL787783

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1980
Volume: 23
Issue: 3
First Page: 335
Last Page: 338
DOI: 10.1021/jm00177a029

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	46	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：IUPHAR-DB 靶标：H2 receptor (Histamine receptors) [Rattus norvegicus]

External ID: 263_Rat

Protocol: The International Union of Basic and Clinical Pharmacology/British Pharmacological Society (IUPHAR/BPS) Guide to PHARMACOLOGY Database (GtoPdb) uses expert subcommittees to collate peer-reviewed information from the published literature regarding individual protein targets, and describes the pharmacology, genetics, function and anatomy of each target. Its pages provide a richly curated overview of the pharmacology of receptors, ion channels, enzymes and other target types, which can be found by following the external link to the GtoPdb website.

Comment: The data collected focuses on ligands at human receptors. Data are provided at rat or mouse orthologues where there are significant species differences, or where data are not yet available at the human target.

Information on individual experimental protocols can be found in the primary references listed for each ligand.

Affinity data are expressed as pKi [-log(Ki)], pKd [-log(Kd)], pIC50 [-log(IC50)], pEC50 [-log(EC50)], pKB [-log(KB)], pA2 or as a micromolar concentration range. In most cases the original concentration can be found in the primary reference.

pKi_min	pKi_max	pKd_min	pKd_max	Type	Action	Reference (PubMed ID)
5.8	5.8			Antagonist	Antagonist	9384502
5.5	5.5			Antagonist	Antagonist	8692899
9.2	9.2			Antagonist	Antagonist	9384502
		8.7	8.7	Antagonist	Antagonist	8961278
5.9	5.9			Antagonist	Antagonist	9384502
6.2	6.2			Antagonist	Antagonist	9384502

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3256104

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1977
Volume: 20
Issue: 4
First Page: 537
Last Page: 540
DOI: 10.1021/jm00214a015

Standard Type	Standard Relation	Standard Value
FC	=	38

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL787781

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1980
Volume: 23
Issue: 3
First Page: 335
Last Page: 338
DOI: 10.1021/jm00177a029

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	76	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3256103

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1977
Volume: 20
Issue: 4
First Page: 537
Last Page: 540
DOI: 10.1021/jm00214a015

Standard Type	Standard Relation	Standard Value
FC	=	11

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Histamine H1 receptor

External ID: CHEMBL692567

Protocol: N/A

Comment: Journal: J Med Chem
Year: 1990
Volume: 33
Issue: 1
First Page: 4
Last Page: 11
DOI: 10.1021/jm00163a001

Target ChEMBL ID: CHEMBL3943
ChEMBL Target Name: Histamine H1 receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value
KB	=	0.01

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL792121

Protocol: N/A

Comment: Journal: J Med Chem
Year: 1980
Volume: 23
Issue: 3
First Page: 335
Last Page: 338
DOI: 10.1021/jm00177a029

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Volume	=	2.99	ml

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL792118

Protocol: N/A

Comment: Journal: J Med Chem
Year: 1980
Volume: 23
Issue: 3
First Page: 335
Last Page: 338
DOI: 10.1021/jm00177a029

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Volume	=	1.7	ml

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3254006

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1977
Volume: 20
Issue: 7
First Page: 901
Last Page: 906
DOI: 10.1021/jm00217a007

Standard Type	Standard Relation	Standard Value
pKa	=	6.8
pKa	=	6.8

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL791700

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1980
Volume: 23
Issue: 3
First Page: 335
Last Page: 338
DOI: 10.1021/jm00177a029

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value
mequiv of HCl	=	0.064

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Histamine H2 receptor

External ID: CHEMBL3231654

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1979
Volume: 22
Issue: 3
First Page: 301
Last Page: 306
DOI: 10.1021/jm00189a016

Target ChEMBL ID: CHEMBL4654
ChEMBL Target Name: Histamine H2 receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
EC50	=	0.28	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3254009

Protocol: N/A

Comment: Journal: J Med Chem
Year: 1977
Volume: 20
Issue: 7
First Page: 901
Last Page: 906
DOI: 10.1021/jm00217a007

Standard Type	Standard Relation	Standard Value	Standard Units
solubility	=	1.14	%
solubility	=	0.32	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3254008

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1977
Volume: 20
Issue: 7
First Page: 901
Last Page: 906
DOI: 10.1021/jm00217a007

Standard Type	Standard Relation	Standard Value
LogP	=	2.5
LogP	=	3.2

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Histamine H2 receptor

External ID: CHEMBL693346

Protocol: N/A

Comment: Journal: J Med Chem
Year: 1990
Volume: 33
Issue: 1
First Page: 4
Last Page: 11
DOI: 10.1021/jm00163a001

Target ChEMBL ID: CHEMBL2882
ChEMBL Target Name: Histamine H2 receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value
KB	=	7.9E-7
KB	=	2.0E-8
KB	=	9.2E-7

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Histamine H2 receptor

External ID: CHEMBL3231656

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1979
Volume: 22
Issue: 3
First Page: 301
Last Page: 306
DOI: 10.1021/jm00189a016

Target ChEMBL ID: CHEMBL2882
ChEMBL Target Name: Histamine H2 receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value
Ratio	=	0.003

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL791703

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1980
Volume: 23
Issue: 3
First Page: 335
Last Page: 338
DOI: 10.1021/jm00177a029

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value
mequiv of HCl	=	0.148

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Histamine H3 receptor

External ID: CHEMBL694087

Protocol: N/A

Comment: Journal: J Med Chem
Year: 1990
Volume: 33
Issue: 1
First Page: 4
Last Page: 11
DOI: 10.1021/jm00163a001

Target ChEMBL ID: CHEMBL4124
ChEMBL Target Name: Histamine H3 receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Relation	Standard Value
KB	=	3.3E-5
KB	>	1.2E-5
KB	=	2.5E-6
KB	>	6.0E-8

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Histamine H2 receptor

External ID: CHEMBL694989

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1986
Volume: 29
Issue: 1
First Page: 44
Last Page: 49
DOI: 10.1021/jm00151a007

Target ChEMBL ID: CHEMBL2882
ChEMBL Target Name: Histamine H2 receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value
-Log KB	=	6.1
-Log KB	=	6.04
-Log KB	=	5.84
-Log KB	<	4.5
-Log KB	=	7.31
-Log KB	=	6.31
-Log KB	=	6.44
-Log KB	<	4
-Log KB	=	4.57
-Log KB	=	4.8
-Log KB	=	5.13
-Log KB	=	4.23
-Log KB	=	5.85
-Log KB	=	4.69

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Canis lupus familiaris

External ID: CHEMBL3231657

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1979
Volume: 22
Issue: 3
First Page: 301
Last Page: 306
DOI: 10.1021/jm00189a016

Target ChEMBL ID: CHEMBL373
ChEMBL Target Name: Canis familiaris
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	76	%
Inhibition	<	25	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Canis lupus familiaris

External ID: CHEMBL3231660

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1979
Volume: 22
Issue: 3
First Page: 301
Last Page: 306
DOI: 10.1021/jm00189a016

Target ChEMBL ID: CHEMBL373
ChEMBL Target Name: Canis familiaris
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	46	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Canis lupus familiaris

External ID: CHEMBL3231565

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1979
Volume: 22
Issue: 3
First Page: 295
Last Page: 301
DOI: 10.1021/jm00189a015

Target ChEMBL ID: CHEMBL373
ChEMBL Target Name: Canis familiaris
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	5	%
Inhibition	=	91	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Canis lupus familiaris

External ID: CHEMBL3231564

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1979
Volume: 22
Issue: 3
First Page: 295
Last Page: 301
DOI: 10.1021/jm00189a015

Target ChEMBL ID: CHEMBL373
ChEMBL Target Name: Canis familiaris
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	65	%
Inhibition	=	74	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Canis lupus familiaris

External ID: CHEMBL3231566

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1979
Volume: 22
Issue: 3
First Page: 295
Last Page: 301
DOI: 10.1021/jm00189a015

Target ChEMBL ID: CHEMBL373
ChEMBL Target Name: Canis familiaris
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	64	%
Inhibition	=	83	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Canis lupus familiaris

External ID: CHEMBL3231648

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1979
Volume: 22
Issue: 3
First Page: 295
Last Page: 301
DOI: 10.1021/jm00189a015

Target ChEMBL ID: CHEMBL373
ChEMBL Target Name: Canis familiaris
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	70	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Histamine H2 receptor

External ID: CHEMBL3253587

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1977
Volume: 20
Issue: 7
First Page: 901
Last Page: 906
DOI: 10.1021/jm00217a007

Target ChEMBL ID: CHEMBL2882
ChEMBL Target Name: Histamine H2 receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
1.4	Kb	=	1400	nM
22	Kb	=	22000	nM
8.3	Kb	=	8300	nM
8.1	Kb	=	8100	nM
16	Kb	=	16000	nM
7.1	Kb	=	7100	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Canis lupus familiaris

External ID: CHEMBL3231647

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1979
Volume: 22
Issue: 3
First Page: 295
Last Page: 301
DOI: 10.1021/jm00189a015

Target ChEMBL ID: CHEMBL373
ChEMBL Target Name: Canis familiaris
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	83	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Canis lupus familiaris

External ID: CHEMBL3231649

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1979
Volume: 22
Issue: 3
First Page: 295
Last Page: 301
DOI: 10.1021/jm00189a015

Target ChEMBL ID: CHEMBL373
ChEMBL Target Name: Canis familiaris
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	90	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Histamine H2 receptor

External ID: CHEMBL3253588

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1977
Volume: 20
Issue: 7
First Page: 901
Last Page: 906
DOI: 10.1021/jm00217a007

Target ChEMBL ID: CHEMBL4654
ChEMBL Target Name: Histamine H2 receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
1.4	Kb	=	1400	nM
7.1	Kb	=	7100	nM
7.1	Kb	=	7100	nM
4.9	Kb	=	4900	nM
5.5	Kb	=	5500	nM
6.9	Kb	=	6900	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL638177

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1986
Volume: 29
Issue: 1
First Page: 44
Last Page: 49
DOI: 10.1021/jm00151a007

Standard Type	Standard Relation	Standard Value
LogD	=	0.4
LogD	=	0.55
LogD	=	0.13
LogD	=	-0.4
LogD	=	1.04
LogD	=	-0.87
LogD	=	-0.2
LogD	=	0.79
LogD	=	-0.74
LogD	=	0.8
LogD	=	0.02
LogD	=	-0.08
LogD	=	-0.4
LogD	=	-0.06

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL3058121

Protocol: N/A

Comment: Journal: Med Chem Res
Year: 2004
Volume: 13
Issue: 1
First Page: 78
Last Page: 87
DOI: 10.1007/s00044-004-0012-z

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Activity				Dose-dependent effect
ED50	=	464	nmol
Activity				Dose-dependent effect
ED50	=	184	nmol
ED50	>	320	nmol
ED50	=	370	nmol
ED50	=	217	nmol
ED50	=	85	nmol
ED50	>	262	nmol
ED50	>	504	nmol
ED50	>	342	nmol
Activity				Dose-dependent effect
ED50	=	67	nmol
Activity				Dose-dependent effect
ED50	=	330	nmol

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL3058123

Protocol: N/A

Comment: Journal: Med Chem Res
Year: 2004
Volume: 13
Issue: 1
First Page: 78
Last Page: 87
DOI: 10.1007/s00044-004-0012-z

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Activity				Dose-dependent effect
ED50	=	464	nmol
Activity				Dose-dependent effect
ED50	=	184	nmol
ED50	>	320	nmol
ED50	=	370	nmol
ED50	=	217	nmol
ED50	=	85	nmol
ED50	>	262	nmol
ED50	>	504	nmol
ED50	>	342	nmol
Activity				Dose-dependent effect
ED50	=	67	nmol
Activity				Dose-dependent effect
ED50	=	330	nmol

34839-70-8 靶点实验数据