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348-25-4 靶点实验数据

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Nitric oxide synthase, brain
External ID: CHEMBL906410
Protocol: N/A
Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2007
Volume: 17
Issue: 11
First Page: 3177
Last Page: 3180
DOI: 10.1016/j.bmcl.2007.03.024

Target ChEMBL ID: CHEMBL3048
ChEMBL Target Name: Nitric-oxide synthase, brain
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned
PubChem Standard ValueStandard TypeStandard RelationStandard ValueStandard Units
44.3IC50=44300nM
100IC50>100000nM
17IC50=17000nM
59.3IC50=59300nM
37IC50=37000nM
4.3IC50=4300nM
22IC50=22000nM
100IC50>100000nM
14.3IC50=14300nM
4.2IC50=4200nM
0.6IC50=600nM
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:N/A
External ID: CHEMBL3301363
Protocol: N/A
Comment: Data Source: AstraZeneca DMPK/physicochemical
Standard TypeStandard Value
LogD7.41.56
LogD7.41.39
LogD7.4-0.78
LogD7.42.22
LogD7.43
LogD7.41.91
LogD7.4-0.84
LogD7.41.19
LogD7.4-1.08
LogD7.43.08
LogD7.43.65
LogD7.4-0.5
LogD7.42.43
LogD7.42.3
LogD7.43.65
LogD7.44.3
LogD7.43.26
LogD7.42.55
LogD7.41.69
LogD7.41.46
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Nitric oxide synthase, brain
External ID: CHEMBL906411
Protocol: N/A
Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2007
Volume: 17
Issue: 11
First Page: 3177
Last Page: 3180
DOI: 10.1016/j.bmcl.2007.03.024

Target ChEMBL ID: CHEMBL3048
ChEMBL Target Name: Nitric-oxide synthase, brain
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned
Standard TypeStandard RelationStandard ValueStandard Units
Inhibition=35%
Inhibition=58%
Inhibition=100%
Inhibition=57%
Inhibition=38%
Inhibition=100%
Inhibition=61%
Inhibition=72%
Inhibition=100%
Inhibition=68%
Inhibition=45%
Inhibition=68%
Inhibition=100%