HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL781806

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1997
Volume: 40
Issue: 12
First Page: 1827
Last Page: 1834
DOI: 10.1021/jm960280m

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value
Cytoprotective effect	=	4.7
Cytoprotective effect	=	0.25
Cytoprotective effect	=	5
Cytoprotective effect	=	3.8
Cytoprotective effect	=	0.43
Cytoprotective effect	=	4.75
Cytoprotective effect	=	4.8
Cytoprotective effect	=	3.5
Cytoprotective effect	=	1.3
Cytoprotective effect	=	4.6
Cytoprotective effect	=	4.6
Cytoprotective effect	=	4.3
Cytoprotective effect	=	5
Cytoprotective effect	=	4.3
Cytoprotective effect	=	0.55
Cytoprotective effect	=	4.3
Cytoprotective effect	=	4.62
Cytoprotective effect	=	4.5
Cytoprotective effect	=	4.66
Cytoprotective effect	=	4.75

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 1

External ID: CHEMBL1938062

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2012
Volume: 22
Issue: 1
First Page: 267
Last Page: 270
DOI: 10.1016/j.bmcl.2011.11.018

Target ChEMBL ID: CHEMBL261
ChEMBL Target Name: Carbonic anhydrase I
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
13.6	Ki	=	13600	nM
4.69	Ki	=	4690	nM
68.7	Ki	=	68700	nM
19.1	Ki	=	19100	nM
9.6	Ki	=	9600	nM
2.48	Ki	=	2480	nM
7.52	Ki	=	7520	nM
7.97	Ki	=	7970	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 9

External ID: CHEMBL1938064

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem Lett
Year: 2012
Volume: 22
Issue: 1
First Page: 267
Last Page: 270
DOI: 10.1016/j.bmcl.2011.11.018

Target ChEMBL ID: CHEMBL3594
ChEMBL Target Name: Carbonic anhydrase IX
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
4.42	Ki	=	4420	nM
0.92	Ki	=	920	nM
3.38	Ki	=	3380	nM
2.47	Ki	=	2470	nM
3.66	Ki	=	3660	nM
7.45	Ki	=	7450	nM
9.51	Ki	=	9510	nM
1.6	Ki	=	1600	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 2

External ID: CHEMBL1938063

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2012
Volume: 22
Issue: 1
First Page: 267
Last Page: 270
DOI: 10.1016/j.bmcl.2011.11.018

Target ChEMBL ID: CHEMBL205
ChEMBL Target Name: Carbonic anhydrase II
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
100	Ki	>	100000	nM
100	Ki	>	100000	nM
100	Ki	>	100000	nM
100	Ki	>	100000	nM
100	Ki	>	100000	nM
100	Ki	>	100000	nM
100	Ki	>	100000	nM
100	Ki	>	100000	nM

3393-45-1 靶点实验数据