HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL824595

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1980
Volume: 23
Issue: 3
First Page: 242
Last Page: 251
DOI: 10.1021/jm00177a007

Standard Type	Standard Relation	Standard Value
Ka'	=	1
Ka'	=	18
Ka'	=	3.1
Ka'	=	2.9
Ka'	=	4.3
Ka'	=	1.8
Ka'	=	0.9
Ka'	=	0.82
Ka'	=	1.5
Ka'	=	2.1
Ka'	=	2.4

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：cAMP-specific 3',5'-cyclic phosphodiesterase 4A

External ID: CHEMBL821497

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1980
Volume: 23
Issue: 3
First Page: 242
Last Page: 251
DOI: 10.1021/jm00177a007

Target ChEMBL ID: CHEMBL2093863
ChEMBL Target Name: Phosphodiesterase 4
ChEMBL Target Type: PROTEIN FAMILY - Target is a group of closely related proteins
Relationship Type: H - Homologous protein target assigned
Confidence: Multiple homologous protein targets may be assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
9.1	IC50	=	9100	nM
500	IC50	=	500000	nM	Outside typical range
29	IC50	=	29000	nM
330	IC50	=	330000	nM	Outside typical range
200	IC50	=	200000	nM	Outside typical range
10	IC50	=	10000	nM
33	IC50	=	33000	nM
17	IC50	=	17000	nM
75	IC50	=	75000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：cAMP-specific 3',5'-cyclic phosphodiesterase 4A

External ID: CHEMBL821997

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1980
Volume: 23
Issue: 3
First Page: 242
Last Page: 251
DOI: 10.1021/jm00177a007

Target ChEMBL ID: CHEMBL2093863
ChEMBL Target Name: Phosphodiesterase 4
ChEMBL Target Type: PROTEIN FAMILY - Target is a group of closely related proteins
Relationship Type: H - Homologous protein target assigned
Confidence: Multiple homologous protein targets may be assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
18	IC50	=	18000	nM
150	IC50	=	150000	nM	Outside typical range
36	IC50	=	36000	nM
400	IC50	>	400000	nM	Outside typical range
56	IC50	=	56000	nM
16	IC50	=	16000	nM
57	IC50	=	57000	nM
53	IC50	=	53000	nM
40	IC50	=	40000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：cAMP-specific 3',5'-cyclic phosphodiesterase 4A

External ID: CHEMBL821996

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1980
Volume: 23
Issue: 3
First Page: 242
Last Page: 251
DOI: 10.1021/jm00177a007

Target ChEMBL ID: CHEMBL2093863
ChEMBL Target Name: Phosphodiesterase 4
ChEMBL Target Type: PROTEIN FAMILY - Target is a group of closely related proteins
Relationship Type: H - Homologous protein target assigned
Confidence: Multiple homologous protein targets may be assigned

Standard Type	Standard Relation	Standard Value
Hydrolysis	=	1
Hydrolysis	<	0.05
Hydrolysis	<	0.05
Hydrolysis	<	0.05
Hydrolysis	<	0.05
Hydrolysis	<	0.05
Hydrolysis	=	0.46
Hydrolysis	=	0.3
Hydrolysis	=	0.8
Hydrolysis	<	0.05
Hydrolysis	<	0.05

32115-08-5 靶点实验数据