HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL880881

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1997
Volume: 40
Issue: 23
First Page: 3773
Last Page: 3780
DOI: 10.1021/jm970292n

Standard Type	Standard Relation	Standard Value	Standard Units
kDPPH	=	4.6	M-1 s-1
kDPPH	=	2.1	M-1 s-1
kDPPH	<	1	M-1 s-1
kDPPH	=	7	M-1 s-1
kDPPH	<	2	M-1 s-1
kDPPH	=	17.6	M-1 s-1
kDPPH	=	50.5	M-1 s-1
kDPPH	<	2	M-1 s-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：5-lipoxygenase

External ID: CHEMBL767669

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1997
Volume: 40
Issue: 23
First Page: 3773
Last Page: 3780
DOI: 10.1021/jm970292n

Target ChEMBL ID: CHEMBL2980
ChEMBL Target Name: Arachidonate 5-lipoxygenase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
37	IC50	=	37000	nM
30	IC50	>	30000	nM
4	IC50	=	4000	nM
30	IC50	>	30000	nM
30	IC50	>	30000	nM
30	IC50	>	30000	nM
10	IC50	=	10000	nM
30	IC50	>	30000	nM
2	IC50	=	2000	nM
4	IC50	=	4000	nM
7	IC50	=	7000	nM
14	IC50	=	14000	nM
30	IC50	>	30000	nM
8	IC50	=	8000	nM
6	IC50	=	6000	nM
8	IC50	=	8000	nM
30	IC50	>	30000	nM
12	IC50	=	12000	nM
20	IC50	=	20000	nM
30	IC50	>	30000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HaCaT

External ID: CHEMBL694131

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1997
Volume: 40
Issue: 23
First Page: 3773
Last Page: 3780
DOI: 10.1021/jm970292n

Target ChEMBL ID: CHEMBL614392
ChEMBL Target Name: HaCaT
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.6	IC50	=	600	nM
5	IC50	>	5000	nM
5	IC50	>	5000	nM
1.4	IC50	=	1400	nM
5	IC50	>	5000	nM
5	IC50	>	5000	nM
5	IC50	>	5000	nM
5	IC50	>	5000	nM
5	IC50	>	5000	nM
5	IC50	>	5000	nM
5	IC50	>	5000	nM
5	IC50	>	5000	nM
0.5	IC50	=	500	nM
4.2	IC50	=	4200	nM
3.3	IC50	=	3300	nM
2.1	IC50	=	2100	nM
5	IC50	>	5000	nM
4.3	IC50	=	4300	nM
3.7	IC50	=	3700	nM
5	IC50	>	5000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL843921

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1997
Volume: 40
Issue: 23
First Page: 3773
Last Page: 3780
DOI: 10.1021/jm970292n

Standard Type	Standard Relation	Standard Value
Ratio	=	0.33
Ratio	<	0.3
Ratio	<	0.3
Ratio	=	2.89
Ratio	<	0.3
Ratio	=	1.38
Ratio	=	1.04
Ratio	=	2.95
Ratio	<	0.3
Ratio	<	0.3
Ratio	=	3.96
Ratio	<	0.3
Ratio	=	0.58
Ratio	=	2.04
Ratio	=	2.35
Ratio	=	2.9
Ratio	=	2.54
Ratio	<	0.3
Ratio	<	0.3
Ratio	<	0.3

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL634679

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1997
Volume: 40
Issue: 23
First Page: 3773
Last Page: 3780
DOI: 10.1021/jm970292n

Standard Type	Standard Relation	Standard Value
LogP	=	3.7
LogP	=	5.02
LogP	=	2.74
LogP	=	4.23
LogP	=	4.16
LogP	=	1.19
LogP	=	2.96
LogP	=	3.99
LogP	=	4.49
LogP	=	4.06
LogP	=	3.37
LogP	=	3.51
LogP	=	2.91
LogP	=	3.9
LogP	=	4.8
LogP	=	3.25
LogP	=	3.44
LogP	=	5.05
LogP	=	3.68
LogP	=	2.66

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HaCaT

External ID: CHEMBL694134

Protocol: N/A

Comment: Journal: J Med Chem
Year: 1997
Volume: 40
Issue: 23
First Page: 3773
Last Page: 3780
DOI: 10.1021/jm970292n

Target ChEMBL ID: CHEMBL614392
ChEMBL Target Name: HaCaT
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
LDH	=	247	MU
LDH	=	159	MU
LDH	=	384	MU
LDH	=	294	MU
LDH	=	170	MU
LDH	=	170	MU
LDH	=	131	MU
LDH	=	376	MU
LDH	=	114	MU
LDH	=	211	MU
LDH	=	243	MU
LDH	=	179	MU
LDH	=	137	MU
LDH	=	263	MU
LDH	=	214	MU
LDH	=	161	MU
LDH	=	317	MU
LDH	=	165	MU

Standard Type	Standard Relation	Standard Value	Standard Units
LDH	=	247	MU
LDH	=	159	MU
LDH	=	384	MU
LDH	=	294	MU
LDH	=	170	MU
LDH	=	170	MU
LDH	=	131	MU
LDH	=	376	MU
LDH	=	114	MU
LDH	=	211	MU
LDH	=	243	MU
LDH	=	179	MU
LDH	=	137	MU
LDH	=	263	MU
LDH	=	214	MU
LDH	=	161	MU
LDH	=	317	MU
LDH	=	165	MU

Standard Type	Standard Relation	Standard Value	Standard Units
LDH	=	247	MU
LDH	=	159	MU
LDH	=	384	MU
LDH	=	294	MU
LDH	=	170	MU
LDH	=	170	MU
LDH	=	131	MU
LDH	=	376	MU
LDH	=	114	MU
LDH	=	211	MU
LDH	=	243	MU
LDH	=	179	MU
LDH	=	137	MU
LDH	=	263	MU
LDH	=	214	MU
LDH	=	161	MU
LDH	=	317	MU
LDH	=	165	MU

31991-54-5 靶点实验数据

Standard Type	Standard Relation	Standard Value	Standard Units
LDH	=	247	MU
LDH	=	159	MU
LDH	=	384	MU
LDH	=	294	MU
LDH	=	170	MU
LDH	=	170	MU
LDH	=	131	MU
LDH	=	376	MU
LDH	=	114	MU
LDH	=	211	MU
LDH	=	243	MU
LDH	=	179	MU
LDH	=	137	MU
LDH	=	263	MU
LDH	=	214	MU
LDH	=	161	MU
LDH	=	317	MU
LDH	=	165	MU