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31719-75-2 靶点实验数据

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Dihydrofolate reductase
External ID: CHEMBL4625598
Protocol: N/A
Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem
Year: 2020
Volume: 28
Issue: 15
First Page: 115600
Last Page: 115600
DOI: 10.1016/j.bmc.2020.115600

Target ChEMBL ID: CHEMBL6065
ChEMBL Target Name: Dihydrofolate reductase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned
PubChem Standard ValueStandard TypeStandard RelationStandard ValueStandard UnitsActivity CommentData Validity Comment
442IC50=442000nMOutside typical range
IC50Not Determined
454IC50=454000nMOutside typical range
26IC50=26000nM
500IC50>500000nMOutside typical range
76IC50=76000nM
81IC50=81000nM
500IC50>500000nMOutside typical range
128IC50=128000nMOutside typical range
7IC50=7000nM
36IC50=36000nM
230IC50=230000nMOutside typical range
35IC50=35000nM
500IC50>500000nMOutside typical range