HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Matrix metalloproteinase-14

External ID: CHEMBL1002951

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2008
Volume: 16
Issue: 19
First Page: 8781
Last Page: 8794
DOI: 10.1016/j.bmc.2008.08.058

Target ChEMBL ID: CHEMBL3869
ChEMBL Target Name: Matrix metalloproteinase 14
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
4.71	IC50	=	4710	nM
0.772	IC50	=	772	nM
66.9	IC50	=	66900	nM
5.29	Ki	>	5290	nM
	Activity				Not Active
0.9	Ki	=	900	nM
0.582	IC50	=	582	nM
24	IC50	=	24000	nM
0.93	IC50	=	930	nM
5	IC50	=	5000	nM
0.14	Ki	=	140	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Matrix metalloproteinase-9

External ID: CHEMBL1002949

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2008
Volume: 16
Issue: 19
First Page: 8781
Last Page: 8794
DOI: 10.1016/j.bmc.2008.08.058

Target ChEMBL ID: CHEMBL321
ChEMBL Target Name: Matrix metalloproteinase 9
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
100	IC50	>	100000	nM
2.128	Ki	>	2128	nM
1.67	IC50	=	1670	nM
0.304	IC50	=	304	nM
2.42	IC50	=	2420	nM
10	Ki	>	10000	nM
2.128	Ki	>	2128	nM
20	IC50	=	20000	nM
0.6	Ki	=	600	nM
0.1	Ki	=	100	nM
0.98	IC50	=	980	nM
0.777	IC50	=	777	nM
5.5	IC50	=	5500	nM
0.56	IC50	=	560	nM
7	IC50	>	7000	nM
1.265	Ki	=	1265	nM
5	IC50	>	5000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL944040

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2007
Volume: 17
Issue: 24
First Page: 6750
Last Page: 6753
DOI: 10.1016/j.bmcl.2007.10.042

Standard Type	Standard Relation	Standard Value	Standard Units
Solubility	<	1	ug.mL-1
Solubility	=	1	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Interstitial collagenase

External ID: CHEMBL1002943

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2008
Volume: 16
Issue: 19
First Page: 8781
Last Page: 8794
DOI: 10.1016/j.bmc.2008.08.058

Target ChEMBL ID: CHEMBL332
ChEMBL Target Name: Matrix metalloproteinase-1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
32	Ki	=	32000	nM
4.949	Ki	>	4949	nM
8.78	IC50	=	8780	nM
5	IC50	>	5000	nM
10	Ki	>	10000	nM
	Activity				Not Active
100	IC50	>	100000	nM
5.248	Ki	=	5248	nM
37.3	IC50	=	37300	nM
5.9	IC50	=	5900	nM
400	IC50	>	400000	nM		Outside typical range
4.949	Ki	>	4949	nM
5	IC50	>	5000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Stromelysin-1

External ID: CHEMBL944034

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2007
Volume: 17
Issue: 24
First Page: 6750
Last Page: 6753
DOI: 10.1016/j.bmcl.2007.10.042

Target ChEMBL ID: CHEMBL283
ChEMBL Target Name: Matrix metalloproteinase 3
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.174	IC50	=	174	nM
0.002	IC50	=	2	nM
0.001	IC50	=	1	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Stromelysin-1

External ID: CHEMBL1002945

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2008
Volume: 16
Issue: 19
First Page: 8781
Last Page: 8794
DOI: 10.1016/j.bmc.2008.08.058

Target ChEMBL ID: CHEMBL283
ChEMBL Target Name: Matrix metalloproteinase 3
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
10	IC50	=	10000	nM
0.082	Ki	=	82	nM
3.56	IC50	=	3560	nM
100	Ki	>	100000	nM
4.5	Ki	>	4500	nM
4.501	Ki	>	4501	nM
	Activity				Not Active
100	IC50	>	100000	nM
4.5	Ki	>	4500	nM
10	Ki	=	10000	nM
0.39	IC50	=	390	nM
0.0021	IC50	=	2.1	nM
0.081	IC50	=	81	nM
0.04	Ki	=	40	nM
0.762	Ki	=	762	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：72 kDa type IV collagenase

External ID: CHEMBL944035

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2007
Volume: 17
Issue: 24
First Page: 6750
Last Page: 6753
DOI: 10.1016/j.bmcl.2007.10.042

Target ChEMBL ID: CHEMBL333
ChEMBL Target Name: Matrix metalloproteinase-2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.62	IC50	=	620	nM
0.457	IC50	=	457	nM
0.534	IC50	=	534	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：72 kDa type IV collagenase

External ID: CHEMBL1002944

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2008
Volume: 16
Issue: 19
First Page: 8781
Last Page: 8794
DOI: 10.1016/j.bmc.2008.08.058

Target ChEMBL ID: CHEMBL333
ChEMBL Target Name: Matrix metalloproteinase-2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
100	IC50	>	100000	nM
3.333	Ki	>	3333	nM
0.355	IC50	=	355	nM
0.035	IC50	=	35	nM
2.17	Ki	=	2170	nM
10	Ki	>	10000	nM
3.333	Ki	>	3333	nM
4	IC50	=	4000	nM
3	Ki	>	3000	nM
0.046	Ki	=	46	nM
100	IC50	>	100000	nM
0.664	IC50	=	664	nM
0.75	IC50	=	750	nM
0.135	IC50	=	135	nM
0.192	Ki	=	192	nM
5	IC50	>	5000	nM

312930-75-9 靶点实验数据