HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Prostaglandin G/H synthase 1

External ID: CHEMBL5543877

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur J Med Chem
Year: 2024
Volume: 266
First Page: 116138
Last Page: 116138
DOI: 10.1016/j.ejmech.2024.116138

Target ChEMBL ID: CHEMBL2949
ChEMBL Target Name: Prostaglandin G/H synthase 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
7.43	IC50	=	7430	nM
6.92	IC50	=	6920	nM
12.23	IC50	=	12230	nM
3.62	IC50	=	3620	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Prostaglandin G/H synthase 2

External ID: CHEMBL5543878

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur J Med Chem
Year: 2024
Volume: 266
First Page: 116138
Last Page: 116138
DOI: 10.1016/j.ejmech.2024.116138

Target ChEMBL ID: CHEMBL230
ChEMBL Target Name: Prostaglandin G/H synthase 2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.091	IC50	=	91	nM
0.23	IC50	=	230	nM
0.049	IC50	=	49	nM
0.473	IC50	=	473	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5543879

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur J Med Chem
Year: 2024
Volume: 266
First Page: 116138
Last Page: 116138
DOI: 10.1016/j.ejmech.2024.116138

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
1.72	IC50	=	1720	nM
4.31	IC50	=	4310	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5543881

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2024
Volume: 266
First Page: 116138
Last Page: 116138
DOI: 10.1016/j.ejmech.2024.116138

Standard Type	Standard Relation	Standard Value
Ratio IC50	=	1.25
Ratio IC50	=	327
Ratio IC50	=	4.52
Ratio IC50	=	195

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL5543882

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2024
Volume: 266
First Page: 116138
Last Page: 116138
DOI: 10.1016/j.ejmech.2024.116138

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：RAW264.7

External ID: CHEMBL5543883

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2024
Volume: 266
First Page: 116138
Last Page: 116138
DOI: 10.1016/j.ejmech.2024.116138

Target ChEMBL ID: CHEMBL612557
ChEMBL Target Name: RAW264.7
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	32	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：RAW264.7

External ID: CHEMBL5543884

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2024
Volume: 266
First Page: 116138
Last Page: 116138
DOI: 10.1016/j.ejmech.2024.116138

Target ChEMBL ID: CHEMBL612557
ChEMBL Target Name: RAW264.7
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	32	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：RAW264.7

External ID: CHEMBL5543885

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2024
Volume: 266
First Page: 116138
Last Page: 116138
DOI: 10.1016/j.ejmech.2024.116138

Target ChEMBL ID: CHEMBL612557
ChEMBL Target Name: RAW264.7
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	54	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：RAW264.7

External ID: CHEMBL5543886

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2024
Volume: 266
First Page: 116138
Last Page: 116138
DOI: 10.1016/j.ejmech.2024.116138

Target ChEMBL ID: CHEMBL612557
ChEMBL Target Name: RAW264.7
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	33	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：RAW264.7

External ID: CHEMBL5543887

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2024
Volume: 266
First Page: 116138
Last Page: 116138
DOI: 10.1016/j.ejmech.2024.116138

Target ChEMBL ID: CHEMBL612557
ChEMBL Target Name: RAW264.7
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	43	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：RAW264.7

External ID: CHEMBL5543888

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2024
Volume: 266
First Page: 116138
Last Page: 116138
DOI: 10.1016/j.ejmech.2024.116138

Target ChEMBL ID: CHEMBL612557
ChEMBL Target Name: RAW264.7
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5543889

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2024
Volume: 266
First Page: 116138
Last Page: 116138
DOI: 10.1016/j.ejmech.2024.116138

Standard Type	Activity Comment
Activity	Non-Toxic

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5543891

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2024
Volume: 266
First Page: 116138
Last Page: 116138
DOI: 10.1016/j.ejmech.2024.116138

Standard Type	Activity Comment
Activity	Toxic

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5543892

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2024
Volume: 266
First Page: 116138
Last Page: 116138
DOI: 10.1016/j.ejmech.2024.116138

Standard Type	Activity Comment
Activity	Toxic

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5543893

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2024
Volume: 266
First Page: 116138
Last Page: 116138
DOI: 10.1016/j.ejmech.2024.116138

Standard Type	Activity Comment
Activity	Non-Toxic
Activity	Non-Toxic

3027770-84-6 靶点实验数据