HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Athelia rolfsii

External ID: CHEMBL3054516

Protocol: N/A

Comment: Journal: Biosci. Biotechnol. Biochem.
Year: 1996
Volume: 60
Issue: 5
First Page: 909
Last Page: 910
DOI: 10.1271/bbb.60.909

Target ChEMBL ID: CHEMBL613900
ChEMBL Target Name: Athelia rolfsii
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
GI	=	100	%
GI	=	54	%
GI	=	37	%
GI	=	43	%
GI	=	53	%
GI	=	46	%
GI	=	41	%
GI	=	100	%
GI	=	22	%
GI	=	13	%
GI	=	45	%
GI	=	0	%
GI	=	22	%
GI	=	0	%
GI	=	70	%
GI	=	10	%
GI	=	81	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Athelia rolfsii

External ID: CHEMBL3054517

Protocol: N/A

Comment: Journal: Biosci. Biotechnol. Biochem.
Year: 1996
Volume: 60
Issue: 5
First Page: 909
Last Page: 910
DOI: 10.1271/bbb.60.909

Target ChEMBL ID: CHEMBL613900
ChEMBL Target Name: Athelia rolfsii
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
GI	=	24	%
GI	=	69	%
GI	=	8	%
GI	=	9	%
GI	=	29	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4339315

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2019
Volume: 167
First Page: 146
Last Page: 152
DOI: 10.1016/j.ejmech.2019.02.006

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Inhibition				Not Active
Inhibition				Not Active
Inhibition				Not Active
Inhibition				Not Active
Inhibition	=	60.3	%
Inhibition				Not Active
Inhibition				Not Active
Inhibition	=	17	%
Inhibition	=	13	%
Inhibition	=	64.6	%
Inhibition				Not Active
Inhibition	=	54	%
Inhibition				Not Active
Inhibition	=	21	%
Inhibition				Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Pythium

External ID: CHEMBL3054518

Protocol: N/A

Comment: Journal: Biosci. Biotechnol. Biochem.
Year: 1996
Volume: 60
Issue: 5
First Page: 909
Last Page: 910
DOI: 10.1271/bbb.60.909

Target ChEMBL ID: CHEMBL2367281
ChEMBL Target Name: Pythium
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
GI	=	12	%
GI	=	0	%
GI	=	42	%
GI	=	29	%
GI	=	31	%
GI	=	35	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Pythium

External ID: CHEMBL3054519

Protocol: N/A

Comment: Journal: Biosci. Biotechnol. Biochem.
Year: 1996
Volume: 60
Issue: 5
First Page: 909
Last Page: 910
DOI: 10.1271/bbb.60.909

Target ChEMBL ID: CHEMBL2367281
ChEMBL Target Name: Pythium
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
GI	=	97	%
GI	=	48	%
GI	=	0	%
GI	=	50	%
GI	=	66	%
GI	=	10	%
GI	=	54	%
GI	=	89	%
GI	=	28	%
GI	=	56	%
GI	=	87	%
GI	=	0	%
GI	=	28	%
GI	=	0	%
GI	=	91	%
GI	=	42	%
GI	=	71	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL3582513

Protocol: N/A

Comment: Journal: MedChemComm
Year: 2014
Volume: 5
Issue: 6
First Page: 711
Last Page: 718
DOI: 10.1039/C4MD00022F

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	4.8	%
Inhibition	=	11.5	%
Inhibition	=	21.4	%
Inhibition	=	8.6	%
Inhibition	=	29.9	%
Inhibition	=	77.6	%
Inhibition	=	16.4	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL3582514

Protocol: N/A

Comment: Journal: MedChemComm
Year: 2014
Volume: 5
Issue: 6
First Page: 711
Last Page: 718
DOI: 10.1039/C4MD00022F

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	6.4	%
Inhibition	=	4	%
Inhibition	=	10.8	%
Inhibition	=	3.4	%
Inhibition	=	17.2	%
Inhibition	=	86.9	%
Inhibition	=	5.8	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 1

External ID: CHEMBL2340804

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2013
Volume: 21
Issue: 6
First Page: 1564
Last Page: 1569
DOI: 10.1016/j.bmc.2012.05.019

Target ChEMBL ID: CHEMBL261
ChEMBL Target Name: Carbonic anhydrase I
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
2.6	Ki	=	2600	nM
0.78	Ki	=	780	nM
4.2	Ki	=	4200	nM
5.7	Ki	=	5700	nM
0.83	Ki	=	830	nM
0.71	Ki	=	710	nM
0.77	Ki	=	770	nM
0.63	Ki	=	630	nM
0.65	Ki	=	650	nM
0.69	Ki	=	690	nM
0.54	Ki	=	540	nM
0.32	Ki	=	320	nM
0.82	Ki	=	820	nM
0.5	Ki	=	500	nM
0.68	Ki	=	680	nM
5.1	Ki	=	5100	nM
0.39	Ki	=	390	nM
0.72	Ki	=	720	nM
0.92	Ki	=	920	nM
0.39	Ki	=	390	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL3582511

Protocol: N/A

Comment: Journal: MedChemComm
Year: 2014
Volume: 5
Issue: 6
First Page: 711
Last Page: 718
DOI: 10.1039/C4MD00022F

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	36.8	%
Inhibition	=	26.5	%
Inhibition	=	42.9	%
Inhibition	=	19.6	%
Inhibition	=	54.5	%
Inhibition	=	94.5	%
Inhibition	=	37.9	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 2

External ID: CHEMBL2340803

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2013
Volume: 21
Issue: 6
First Page: 1564
Last Page: 1569
DOI: 10.1016/j.bmc.2012.05.019

Target ChEMBL ID: CHEMBL205
ChEMBL Target Name: Carbonic anhydrase II
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
3.4	Ki	=	3400	nM
0.8	Ki	=	800	nM
4.1	Ki	=	4100	nM
5.2	Ki	=	5200	nM
0.76	Ki	=	760	nM
0.58	Ki	=	580	nM
0.69	Ki	=	690	nM
0.52	Ki	=	520	nM
0.61	Ki	=	610	nM
0.66	Ki	=	660	nM
0.52	Ki	=	520	nM
0.71	Ki	=	710	nM
0.77	Ki	=	770	nM
0.49	Ki	=	490	nM
0.7	Ki	=	700	nM
4.7	Ki	=	4700	nM
0.51	Ki	=	510	nM
0.53	Ki	=	530	nM
0.7	Ki	=	700	nM
0.32	Ki	=	320	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL3582512

Protocol: N/A

Comment: Journal: MedChemComm
Year: 2014
Volume: 5
Issue: 6
First Page: 711
Last Page: 718
DOI: 10.1039/C4MD00022F

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	25	%
Inhibition	=	17.9	%
Inhibition	=	30.5	%
Inhibition	=	15.3	%
Inhibition	=	53.2	%
Inhibition	=	92.3	%
Inhibition	=	25.5	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 7

External ID: CHEMBL2340802

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2013
Volume: 21
Issue: 6
First Page: 1564
Last Page: 1569
DOI: 10.1016/j.bmc.2012.05.019

Target ChEMBL ID: CHEMBL2326
ChEMBL Target Name: Carbonic anhydrase VII
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
72	Ki	=	72000	nM
7.17	Ki	=	7170	nM
0.78	Ki	=	780	nM
7.15	Ki	=	7150	nM
0.82	Ki	=	820	nM
68	Ki	=	68000	nM
6.6	Ki	=	6600	nM
3.22	Ki	=	3220	nM
0.85	Ki	=	850	nM
0.81	Ki	=	810	nM
0.78	Ki	=	780	nM
0.81	Ki	=	810	nM
0.75	Ki	=	750	nM
0.9	Ki	=	900	nM
3.7	Ki	=	3700	nM
3.88	Ki	=	3880	nM
7.25	Ki	=	7250	nM
0.69	Ki	=	690	nM
0.85	Ki	=	850	nM
8.3	Ki	=	8300	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL3582515

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: MedChemComm
Year: 2014
Volume: 5
Issue: 6
First Page: 711
Last Page: 718
DOI: 10.1039/C4MD00022F

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
265.3	IC50	=	265300	nM	Outside typical range
74.8	IC50	=	74800	nM
7.6	IC50	=	7600	nM
130.4	IC50	=	130400	nM	Outside typical range
37.8	IC50	=	37800	nM
24.4	IC50	=	24400	nM
26.4	IC50	=	26400	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4813798

Protocol: N/A

Comment: Journal: Bioorg Med Chem
Year: 2021
Volume: 44
First Page: 116299
Last Page: 116299
DOI: 10.1016/j.bmc.2021.116299

Standard Type	Standard Relation	Standard Value	Standard Units
mortality	=	0	%
mortality	=	80	%
mortality	=	0	%
mortality	=	86.7	%
mortality	=	95	%
mortality	=	95	%
mortality	=	36.7	%
mortality	=	0	%
mortality	=	0	%
mortality	=	86.7	%
mortality	=	100	%
mortality	=	98.3	%
mortality	=	98.3	%
mortality	=	8.3	%
mortality	=	93.3	%
mortality	=	93.3	%
mortality	=	83.3	%
mortality	=	40	%
mortality	=	100	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL3050299

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Med Chem Res
Year: 2012
Volume: 21
Issue: 8
First Page: 1905
Last Page: 1911
DOI: 10.1007/s00044-011-9713-2

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
150.02	IC50	=	150020	nM	Outside typical range
200	IC50	>	200000	nM	Outside typical range
29.61	IC50	=	29610	nM
200	IC50	>	200000	nM	Outside typical range
52.35	IC50	=	52350	nM
200	IC50	>	200000	nM	Outside typical range
12.8	IC50	=	12800	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Monocarboxylate transporter 2

External ID: CHEMBL2078141

Protocol: N/A

Comment: Journal: J. Biol. Chem.
Year: 1998
Volume: 273
Issue: 1
First Page: 28959
Last Page: 28965
DOI: 10.1074/jbc.273.44.28959

Target ChEMBL ID: CHEMBL2073704
ChEMBL Target Name: Monocarboxylate transporter 2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Activity	=	30	%	inhibitor [30% of control]
Activity	=	10	%	inhibitor [10% of control]
Activity	=	10	%	inhibitor [10% of control]
Activity	=	0	%	inhibitor [0% of control]
Activity	=	10	%	inhibitor [10% of control]
Activity	=	30	%	inhibitor [30% of control]
Activity				is not an inhibitor [-]
Activity	=	65	%	inhibitor [65% of control]

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 9

External ID: CHEMBL2340801

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2013
Volume: 21
Issue: 6
First Page: 1564
Last Page: 1569
DOI: 10.1016/j.bmc.2012.05.019

Target ChEMBL ID: CHEMBL3594
ChEMBL Target Name: Carbonic anhydrase IX
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
5.5	Ki	=	5500	nM
0.85	Ki	=	850	nM
6.6	Ki	=	6600	nM
5.9	Ki	=	5900	nM
0.89	Ki	=	890	nM
0.79	Ki	=	790	nM
0.81	Ki	=	810	nM
0.82	Ki	=	820	nM
0.78	Ki	=	780	nM
0.91	Ki	=	910	nM
0.68	Ki	=	680	nM
0.61	Ki	=	610	nM
0.84	Ki	=	840	nM
0.7	Ki	=	700	nM
0.81	Ki	=	810	nM
0.71	Ki	=	710	nM
0.31	Ki	=	310	nM
0.79	Ki	=	790	nM
0.9	Ki	=	900	nM
0.68	Ki	=	680	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Monocarboxylate transporter 1

External ID: CHEMBL2077953

Protocol: N/A

Comment: Journal: J. Biol. Chem.
Year: 1998
Volume: 273
Issue: 1
First Page: 28959
Last Page: 28965
DOI: 10.1074/jbc.273.44.28959

Target ChEMBL ID: CHEMBL2073709
ChEMBL Target Name: Monocarboxylate transporter 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Activity	=	20	%	inhibitor [20% of control]
Activity	=	30	%	inhibitor [30% of control]
Activity	=	40	%	inhibitor [40% of control]
Activity	=	0	%	inhibitor [0% of control]
Activity	=	40	%	inhibitor [40% of control]
Activity	=	20	%	inhibitor [20% of control]
Activity				is not an inhibitor [-]
Activity	=	0	%	inhibitor [0% of control]

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 12

External ID: CHEMBL2340800

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2013
Volume: 21
Issue: 6
First Page: 1564
Last Page: 1569
DOI: 10.1016/j.bmc.2012.05.019

Target ChEMBL ID: CHEMBL3242
ChEMBL Target Name: Carbonic anhydrase XII
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.82	Ki	=	820	nM
0.81	Ki	=	810	nM
7.3	Ki	=	7300	nM
7.2	Ki	=	7200	nM
0.95	Ki	=	950	nM
0.96	Ki	=	960	nM
0.84	Ki	=	840	nM
0.77	Ki	=	770	nM
0.83	Ki	=	830	nM
0.85	Ki	=	850	nM
0.76	Ki	=	760	nM
0.49	Ki	=	490	nM
0.83	Ki	=	830	nM
0.78	Ki	=	780	nM
0.72	Ki	=	720	nM
0.4	Ki	=	400	nM
0.5	Ki	=	500	nM
0.88	Ki	=	880	nM
0.89	Ki	=	890	nM
0.54	Ki	=	540	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 14

External ID: CHEMBL2340799

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2013
Volume: 21
Issue: 6
First Page: 1564
Last Page: 1569
DOI: 10.1016/j.bmc.2012.05.019

Target ChEMBL ID: CHEMBL3510
ChEMBL Target Name: Carbonic anhydrase XIV
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
70	Ki	=	70000	nM
0.65	Ki	=	650	nM
4.1	Ki	=	4100	nM
0.74	Ki	=	740	nM
0.83	Ki	=	830	nM
67	Ki	=	67000	nM
6.5	Ki	=	6500	nM
0.55	Ki	=	550	nM
0.86	Ki	=	860	nM
0.89	Ki	=	890	nM
0.78	Ki	=	780	nM
0.74	Ki	=	740	nM
0.86	Ki	=	860	nM
0.83	Ki	=	830	nM
0.63	Ki	=	630	nM
6.79	Ki	=	6790	nM
6.83	Ki	=	6830	nM
0.73	Ki	=	730	nM
0.8	Ki	=	800	nM
0.8	Ki	=	800	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：DTP/NCI 靶标：N/A

External ID: MCF7_OneDose

Protocol: NCI-60 Human Tumor Cell Lines Screen was performed using the standard one-dose NCI protocol, which is described in more detail at https://dtp.cancer.gov/discovery_development/nci-60/default.htm.

Compounds with GIPRCNT values below 10 were considered active. Activity score was based on GIPRCNT using the following formula:
max(-GIPRCNT/2 + 50, 0)
Score is 0 for GIPRCNT values of 100 or above, 50 for GIPRCNT values of 0, and 100 for GIPRCNT values of -100.

Comment: These data are a subset of the data from the NCI human tumor cell line screen. Compounds are identified by the NCI National Service Center (NSC) number, which is contained in the
PUBCHEM_EXT_DATASOURCE_REGID field. In the NCI cell line identification system, MCF7 is panel number 5, cell number 1. PANELCODE or PANELNAME identify the NCI-60 cell panel. PANELNBR does NOT identify the NCI-60 panel.

EXPID is the NCI internal tracking number for the experiment identifier, and PREFIX = 'S' for the NSCs submitted through the NCI Chemical Agents repository.

Substance concentration unit is indicated in the data table, using the following abbreviations: M = molar (M), u = micrograms/milliliter (microg/mL), V = volumetric fraction.

M_GIPRCNT represents the mean growth percent for that experiment, and N_GIPRCNT indicates the number of values for that NSC within an experiment, while STDEV_GIPRCNT is the standard deviation. Most NSCs are tested once per experiment, resulting in EXP_COUNT = 1.

EXPID	PREFIX	CONCENTRATION_UNIT	CONCENTRATION	PANELNBR	CELLNBR	PANELNAME	CELLNAME	PANELCODE	M_GIPRCNT	N_GIPRCNT	EXP_COUNT
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	88.231	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	87.1119	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	14.4371	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	89.7113	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	97.2463	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	90.0129	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	85.7031	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	30.8539	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	14.2896	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	85.8526	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	83.1036	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	84.2194	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	89.3237	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	85.6034	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	89.6643	1	1
2106OS52	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	91.2503	1	1
2106OS52	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	94.8714	1	1
2106OS52	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	93.7372	1	1
2106OS52	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	112.6132	1	1
2106OS52	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	73.375	1	1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：DTP/NCI 靶标：N/A

External ID: IGROV1_OneDose

Protocol: NCI-60 Human Tumor Cell Lines Screen was performed using the standard one-dose NCI protocol, which is described in more detail at https://dtp.cancer.gov/discovery_development/nci-60/default.htm.

Compounds with GIPRCNT values below 10 were considered active. Activity score was based on GIPRCNT using the following formula:
max(-GIPRCNT/2 + 50, 0)
Score is 0 for GIPRCNT values of 100 or above, 50 for GIPRCNT values of 0, and 100 for GIPRCNT values of -100.

Comment: These data are a subset of the data from the NCI human tumor cell line screen. Compounds are identified by the NCI National Service Center (NSC) number, which is contained in the
PUBCHEM_EXT_DATASOURCE_REGID field. In the NCI cell line identification system, IGROV1 is panel number 6, cell number 10. PANELCODE or PANELNAME identify the NCI-60 cell panel. PANELNBR does NOT identify the NCI-60 panel.

EXPID is the NCI internal tracking number for the experiment identifier, and PREFIX = 'S' for the NSCs submitted through the NCI Chemical Agents repository.

Substance concentration unit is indicated in the data table, using the following abbreviations: M = molar (M), u = micrograms/milliliter (microg/mL), V = volumetric fraction.

M_GIPRCNT represents the mean growth percent for that experiment, and N_GIPRCNT indicates the number of values for that NSC within an experiment, while STDEV_GIPRCNT is the standard deviation. Most NSCs are tested once per experiment, resulting in EXP_COUNT = 1.

EXPID	PREFIX	CONCENTRATION_UNIT	CONCENTRATION	PANELNBR	CELLNBR	PANELNAME	CELLNAME	PANELCODE	M_GIPRCNT	N_GIPRCNT	EXP_COUNT
0809OS51	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	89.6274	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	94.0185	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	77.1805	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	76.1686	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	82.5618	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	88.7561	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	83.5845	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	92.7497	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	70.9555	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	58.7306	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	72.6041	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	90.3839	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	110.2345	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	97.6538	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	93.7697	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	56.4618	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	80.8893	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	79.078	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	-20.3008	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	72.0949	1	1

Standard Type	Standard Relation	Standard Value	Standard Units
GI	=	100	%
GI	=	54	%
GI	=	37	%
GI	=	43	%
GI	=	53	%
GI	=	46	%
GI	=	41	%
GI	=	100	%
GI	=	22	%
GI	=	13	%
GI	=	45	%
GI	=	0	%
GI	=	22	%
GI	=	0	%
GI	=	70	%
GI	=	10	%
GI	=	81	%

Standard Type	Standard Relation	Standard Value	Standard Units
GI	=	97	%
GI	=	48	%
GI	=	0	%
GI	=	50	%
GI	=	66	%
GI	=	10	%
GI	=	54	%
GI	=	89	%
GI	=	28	%
GI	=	56	%
GI	=	87	%
GI	=	0	%
GI	=	28	%
GI	=	0	%
GI	=	91	%
GI	=	42	%
GI	=	71	%

Standard Type	Standard Relation	Standard Value	Standard Units
GI	=	100	%
GI	=	54	%
GI	=	37	%
GI	=	43	%
GI	=	53	%
GI	=	46	%
GI	=	41	%
GI	=	100	%
GI	=	22	%
GI	=	13	%
GI	=	45	%
GI	=	0	%
GI	=	22	%
GI	=	0	%
GI	=	70	%
GI	=	10	%
GI	=	81	%

Standard Type	Standard Relation	Standard Value	Standard Units
GI	=	97	%
GI	=	48	%
GI	=	0	%
GI	=	50	%
GI	=	66	%
GI	=	10	%
GI	=	54	%
GI	=	89	%
GI	=	28	%
GI	=	56	%
GI	=	87	%
GI	=	0	%
GI	=	28	%
GI	=	0	%
GI	=	91	%
GI	=	42	%
GI	=	71	%

2979-06-8 靶点实验数据

Standard Type	Standard Relation	Standard Value	Standard Units
GI	=	100	%
GI	=	54	%
GI	=	37	%
GI	=	43	%
GI	=	53	%
GI	=	46	%
GI	=	41	%
GI	=	100	%
GI	=	22	%
GI	=	13	%
GI	=	45	%
GI	=	0	%
GI	=	22	%
GI	=	0	%
GI	=	70	%
GI	=	10	%
GI	=	81	%

Standard Type	Standard Relation	Standard Value	Standard Units
GI	=	97	%
GI	=	48	%
GI	=	0	%
GI	=	50	%
GI	=	66	%
GI	=	10	%
GI	=	54	%
GI	=	89	%
GI	=	28	%
GI	=	56	%
GI	=	87	%
GI	=	0	%
GI	=	28	%
GI	=	0	%
GI	=	91	%
GI	=	42	%
GI	=	71	%