HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL859415

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2006
Volume: 16
Issue: 5
First Page: 1138
Last Page: 1141
DOI: 10.1016/j.bmcl.2005.11.108

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
ED50	=	125	umol.kg-1
ED50	=	100	umol.kg-1
ED50	=	200	umol.kg-1
ED50	=	120	umol.kg-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Voltage-dependent calcium channel subunit alpha-2/delta-1

External ID: CHEMBL859414

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2006
Volume: 16
Issue: 5
First Page: 1138
Last Page: 1141
DOI: 10.1016/j.bmcl.2005.11.108

Target ChEMBL ID: CHEMBL4676
ChEMBL Target Name: Voltage-gated calcium channel alpha2/delta subunit 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.12023	Ki	=	120.23	nM
1.86209	Ki	=	1862.09	nM
20	Ki	=	20000	nM
0.06	Ki	=	60	nM
0.06026	Ki	=	60.26	nM
0.18	Ki	=	180	nM
0.18197	Ki	=	181.97	nM
30	Ki	=	30000	nM
30.1995	Ki	=	30199.52	nM
0.09	Ki	=	90	nM
0.08913	Ki	=	89.13	nM
100	Ki	>	100000	nM
5.4	Ki	=	5400	nM
5.37032	Ki	=	5370.32	nM
0.031	Ki	=	31	nM
0.0309	Ki	=	30.9	nM
0.12	Ki	=	120	nM
0.10965	Ki	=	109.65	nM
0.1	Ki	=	100	nM
0.10471	Ki	=	104.71	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Neutral amino acid transporter A

External ID: CHEMBL3992322

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL2315
ChEMBL Target Name: Neutral amino acid transporter A
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: SureChEMBL Patent Bioactivity Data

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
2000	IC50	<	2000000	nM	Outside typical range
2000	IC50	<	2000000	nM	Outside typical range
2000	IC50	<	2000000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Amino acid transporter

External ID: CHEMBL3992321

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL3562161
ChEMBL Target Name: Amino acid transporter
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: SureChEMBL Patent Bioactivity Data

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	>=	25	%
Inhibition	>=	25	%
Inhibition	>=	25	%
Inhibition	>=	25	%
Inhibition	>=	25	%
Inhibition	>=	25	%
Inhibition	>=	25	%
Inhibition	>=	25	%
Inhibition	>=	25	%
Inhibition	>=	25	%
Inhibition	>=	25	%
Inhibition	>=	25	%
Inhibition	>=	25	%
Inhibition	>=	25	%
Inhibition	>=	25	%
Inhibition	>=	25	%
Inhibition	>=	25	%
Inhibition	>=	25	%
Inhibition	>=	25	%
Inhibition	>=	25	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL859417

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2006
Volume: 16
Issue: 5
First Page: 1138
Last Page: 1141
DOI: 10.1016/j.bmcl.2005.11.108

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Drug uptake	=	3.41	microg/g
Drug uptake	=	6.3	microg/g
Drug uptake				Not Determined
Drug uptake	=	0.43	microg/g
Drug uptake	=	1.76	microg/g

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Neutral amino acid transporter B(0)

External ID: CHEMBL3992323

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL3562162
ChEMBL Target Name: Neutral amino acid transporter B(0)
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: SureChEMBL Patent Bioactivity Data

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
2000	IC50	<	2000000	nM	Outside typical range
2000	IC50	<	2000000	nM	Outside typical range
2000	IC50	<	2000000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Neutral amino acid transporter A

External ID: CHEMBL3992312

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL2315
ChEMBL Target Name: Neutral amino acid transporter A
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: SureChEMBL Patent Bioactivity Data

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
2139	IC50	=	2139000	nM	Outside typical range
3373	IC50	=	3373000	nM	Outside typical range
656	IC50	=	656000	nM	Outside typical range
188	IC50	=	188000	nM	Outside typical range
1217	IC50	=	1217000	nM	Outside typical range
3000	IC50	>	3000000	nM	Outside typical range
1322	IC50	=	1322000	nM	Outside typical range
377	IC50	=	377000	nM	Outside typical range
948	IC50	=	948000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Amino acid transporter

External ID: CHEMBL3992306

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL3562161
ChEMBL Target Name: Amino acid transporter
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: SureChEMBL Patent Bioactivity Data

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
2271	IC50	=	2271000	nM	Outside typical range
1641	IC50	=	1641000	nM	Outside typical range
57.2	IC50	=	57200	nM
597	IC50	=	597000	nM	Outside typical range
424	IC50	=	424000	nM	Outside typical range
38.9	IC50	=	38900	nM
89.4	IC50	=	89400	nM
1571	IC50	=	1571000	nM	Outside typical range
142.1	IC50	=	142100	nM	Outside typical range
27.9	IC50	=	27900	nM
3000	IC50	=	3000000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Asc-type amino acid transporter 1

External ID: CHEMBL3992305

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Target ChEMBL ID: CHEMBL4105976
ChEMBL Target Name: Asc-type amino acid transporter 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: SureChEMBL Patent Bioactivity Data

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
10000	IC50	>	10000000	nM	Outside typical range
943	IC50	=	943000	nM	Outside typical range
668	IC50	=	668000	nM	Outside typical range
29.3	IC50	=	29300	nM
86	IC50	=	86000	nM
10000	IC50	>	10000000	nM	Outside typical range
217	IC50	=	217000	nM	Outside typical range
348	IC50	=	348000	nM	Outside typical range
101	IC50	=	101000	nM	Outside typical range
258	IC50	=	258000	nM	Outside typical range
62	IC50	=	62000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Glutamate receptor ionotropic, NMDA 3A

External ID: CHEMBL3992308

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL1907608
ChEMBL Target Name: Glutamate NMDA receptor
ChEMBL Target Type: PROTEIN COMPLEX GROUP - Target is a poorly defined protein complex, where subunit composition is unclear (e.g., GABA-A receptor)
Relationship Type: D - Direct protein target assigned
Confidence: Multiple direct protein targets may be assigned

Data Source: SureChEMBL Patent Bioactivity Data

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Dose-dependent effect
Activity	Not Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3992319

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Data Source: SureChEMBL Patent Bioactivity Data

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
3	Activity	=	3	uM
10	Activity	=	10	uM
300	Activity	>	300	uM
10	Activity	=	10	uM
0.3	Activity	=	0.3	uM
1	Activity	=	1	uM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Amino acid transporter

External ID: CHEMBL3992314

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL3562161
ChEMBL Target Name: Amino acid transporter
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: SureChEMBL Patent Bioactivity Data

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
108	IC50	=	108000	nM	Outside typical range
228	IC50	=	228000	nM	Outside typical range
1572	IC50	=	1572000	nM	Outside typical range
283	IC50	=	283000	nM	Outside typical range
83.3	IC50	=	83300	nM
180	IC50	=	180000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Neutral amino acid transporter B(0)

External ID: CHEMBL3992313

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL3562162
ChEMBL Target Name: Neutral amino acid transporter B(0)
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: SureChEMBL Patent Bioactivity Data

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
10000	IC50	>	10000000	nM	Outside typical range
541	IC50	=	541000	nM	Outside typical range
674	IC50	=	674000	nM	Outside typical range
3475	IC50	=	3475000	nM	Outside typical range
945	IC50	=	945000	nM	Outside typical range
3000	IC50	>	3000000	nM	Outside typical range
1728	IC50	=	1728000	nM	Outside typical range
437	IC50	=	437000	nM	Outside typical range
428	IC50	=	428000	nM	Outside typical range

2935-35-5 靶点实验数据