HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5045911

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 5.0
First Page: 4085
Last Page: 4120
DOI: 10.1021/acs.jmedchem.1c01909

Standard Type	Standard Relation	Standard Value
Selectivity ratio	>	500
Selectivity ratio	>	89

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：A549

External ID: CHEMBL5045918

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 5.0
First Page: 4085
Last Page: 4120
DOI: 10.1021/acs.jmedchem.1c01909

Target ChEMBL ID: CHEMBL392
ChEMBL Target Name: A549
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Non-Toxic

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Escherichia coli

External ID: CHEMBL5045906

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 5.0
First Page: 4085
Last Page: 4120
DOI: 10.1021/acs.jmedchem.1c01909

Target ChEMBL ID: CHEMBL354
ChEMBL Target Name: Escherichia coli
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
100	MIC	>	100000	nM
100	MIC	>	100000	nM
100	MIC	>	100000	nM
100	MIC	>	100000	nM
100	MIC	>	100000	nM
100	MIC	>	100000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5045905

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 5.0
First Page: 4085
Last Page: 4120
DOI: 10.1021/acs.jmedchem.1c01909

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.032	IC50	=	32	nM
0.027	IC50	=	27	nM
0.02	IC50	=	20	nM
0.04	IC50	=	40	nM
39	IC50	=	39000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HEK293

External ID: CHEMBL5045920

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 5.0
First Page: 4085
Last Page: 4120
DOI: 10.1021/acs.jmedchem.1c01909

Target ChEMBL ID: CHEMBL614818
ChEMBL Target Name: HEK293
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Non-Toxic

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5045904

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 5.0
First Page: 4085
Last Page: 4120
DOI: 10.1021/acs.jmedchem.1c01909

Standard Type	Standard Relation	Standard Value
LogD	=	3.7
LogD	=	3.7
LogD	=	2.9
LogD	=	4.1
LogD	=	4.3
LogD	=	4.3

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Jurkat

External ID: CHEMBL5045919

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 5.0
First Page: 4085
Last Page: 4120
DOI: 10.1021/acs.jmedchem.1c01909

Target ChEMBL ID: CHEMBL397
ChEMBL Target Name: Jurkat
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Non-Toxic

2909443-06-5 靶点实验数据