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28984-85-2 靶点实验数据

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Transthyretin
External ID: CHEMBL4055896
Protocol: N/A
Comment: Journal: Bioorg Med Chem Lett
Year: 2017
Volume: 27
Issue: 15
First Page: 3441
Last Page: 3449
DOI: 10.1016/j.bmcl.2017.05.080

Target ChEMBL ID: CHEMBL3194
ChEMBL Target Name: Transthyretin
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned
Standard TypeStandard RelationStandard ValueStandard Units
Inhibition=97%
Inhibition=60%
Inhibition=0%
Inhibition=100%
Inhibition=98%
Inhibition=93%
Inhibition=98%
Inhibition=94%
Inhibition=55%
Inhibition=100%
Inhibition=45%
Inhibition=95%
Inhibition=86%
Inhibition=100%
Inhibition=100%
Inhibition=30%
Inhibition=94%
Inhibition=95%
Inhibition=90%
Inhibition=0%
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Salmonella enterica subsp. enterica serovar Typhimurium
External ID: CHEMBL799656
Protocol: N/A
Comment: Journal: J. Med. Chem.
Year: 1991
Volume: 34
Issue: 2
First Page: 786
Last Page: 797
DOI: 10.1021/jm00106a046

Target ChEMBL ID: CHEMBL351
ChEMBL Target Name: Salmonella typhimurium
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular
Standard TypeStandard RelationStandard Value
Activity=1.03
Activity=1.64
Activity=-1.61
Activity=-1.66
Activity=-1.15
Activity=1.02
Activity=-1.72
Activity=0.66
Activity=-2.7
Activity=0.3
Activity=1.17
Activity=1.75
Activity=2.24
Activity=0.59
Activity=0.03
Activity=-0.94
Activity=-1.42
Activity=2.59
Activity=1.51
Activity=3.39
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Transthyretin
External ID: CHEMBL4055897
Protocol: N/A
Comment: Journal: Bioorg Med Chem Lett
Year: 2017
Volume: 27
Issue: 15
First Page: 3441
Last Page: 3449
DOI: 10.1016/j.bmcl.2017.05.080

Target ChEMBL ID: CHEMBL3194
ChEMBL Target Name: Transthyretin
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned
Standard TypeStandard RelationStandard Value
Activity_index=0.14
Activity_index=0
Activity_index=0
Activity_index=1.38
Activity_index=0.2
Activity_index=0.2
Activity_index=0.14
Activity_index=0.74
Activity_index=0
Activity_index=1.36
Activity_index=0
Activity_index=1.56
Activity_index=0.08
Activity_index=0.53
Activity_index=0.16
Activity_index=0
Activity_index=0.23
Activity_index=0.08
Activity_index=0
Activity_index=0
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:N/A
External ID: CHEMBL633737
Protocol: N/A
Comment: Journal: J. Med. Chem.
Year: 1991
Volume: 34
Issue: 2
First Page: 786
Last Page: 797
DOI: 10.1021/jm00106a046
Standard TypeStandard RelationStandard Value
LogP=2.84
LogP=6.24
LogP=1.9
LogP=4.83
LogP=1.87
LogP=3.77
LogP=1.8
LogP=2.68
LogP=2.68
LogP=2.9
LogP=2.35
LogP=4.18
LogP=3.26
LogP=2.79
LogP=6.01
LogP=2.52
LogP=3.43
LogP=6.01
LogP=3.71
LogP=4.44