HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：SK-MEL-28

External ID: CHEMBL5098747

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2021
Volume: 64
Issue: 21.0
First Page: 16147
Last Page: 16158
DOI: 10.1021/acs.jmedchem.1c01459

Target ChEMBL ID: CHEMBL614919
ChEMBL Target Name: SK-MEL-28
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Tde
Activity	Tde

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Baculoviral IAP repeat-containing protein 7

External ID: CHEMBL5098743

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2021
Volume: 64
Issue: 21.0
First Page: 16147
Last Page: 16158
DOI: 10.1021/acs.jmedchem.1c01459

Target ChEMBL ID: CHEMBL1075127
ChEMBL Target Name: Baculoviral IAP repeat-containing protein 7
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Delta Tm	=	58	degrees C
Delta Tm	<=	70	degrees C

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：E3 ubiquitin-protein ligase XIAP

External ID: CHEMBL5098744

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2021
Volume: 64
Issue: 21.0
First Page: 16147
Last Page: 16158
DOI: 10.1021/acs.jmedchem.1c01459

Target ChEMBL ID: CHEMBL4198
ChEMBL Target Name: Inhibitor of apoptosis protein 3
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Delta Tm	=	6.9	degrees C

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：E3 ubiquitin-protein ligase XIAP

External ID: CHEMBL5098745

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2021
Volume: 64
Issue: 21.0
First Page: 16147
Last Page: 16158
DOI: 10.1021/acs.jmedchem.1c01459

Target ChEMBL ID: CHEMBL4198
ChEMBL Target Name: Inhibitor of apoptosis protein 3
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Delta Tm	=	20	degrees C

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：SK-MEL-28

External ID: CHEMBL5098746

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2021
Volume: 64
Issue: 21.0
First Page: 16147
Last Page: 16158
DOI: 10.1021/acs.jmedchem.1c01459

Target ChEMBL ID: CHEMBL614919
ChEMBL Target Name: SK-MEL-28
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Dde
Activity	Dde

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5098739

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2021
Volume: 64
Issue: 21.0
First Page: 16147
Last Page: 16158
DOI: 10.1021/acs.jmedchem.1c01459

Standard Type	Activity Comment
Activity	NA

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Baculoviral IAP repeat-containing protein 7

External ID: CHEMBL5098741

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2021
Volume: 64
Issue: 21.0
First Page: 16147
Last Page: 16158
DOI: 10.1021/acs.jmedchem.1c01459

Target ChEMBL ID: CHEMBL1075127
ChEMBL Target Name: Baculoviral IAP repeat-containing protein 7
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Kinact	=	1.046	/min

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5098742

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2021
Volume: 64
Issue: 21.0
First Page: 16147
Last Page: 16158
DOI: 10.1021/acs.jmedchem.1c01459

Standard Type	Standard Relation	Standard Value	Standard Units
Delta Tm	=	14.5	degrees C
Delta Tm	=	6.2	degrees C

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Baculoviral IAP repeat-containing protein 7

External ID: CHEMBL5098735

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2021
Volume: 64
Issue: 21.0
First Page: 16147
Last Page: 16158
DOI: 10.1021/acs.jmedchem.1c01459

Target ChEMBL ID: CHEMBL1075127
ChEMBL Target Name: Baculoviral IAP repeat-containing protein 7
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：E3 ubiquitin-protein ligase XIAP

External ID: CHEMBL5098736

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2021
Volume: 64
Issue: 21.0
First Page: 16147
Last Page: 16158
DOI: 10.1021/acs.jmedchem.1c01459

Target ChEMBL ID: CHEMBL4198
ChEMBL Target Name: Inhibitor of apoptosis protein 3
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	NA

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Baculoviral IAP repeat-containing protein 7

External ID: CHEMBL5098737

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2021
Volume: 64
Issue: 21.0
First Page: 16147
Last Page: 16158
DOI: 10.1021/acs.jmedchem.1c01459

Target ChEMBL ID: CHEMBL1075127
ChEMBL Target Name: Baculoviral IAP repeat-containing protein 7
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5098738

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2021
Volume: 64
Issue: 21.0
First Page: 16147
Last Page: 16158
DOI: 10.1021/acs.jmedchem.1c01459

Standard Type	Activity Comment
Activity	NA

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Baculoviral IAP repeat-containing protein 7

External ID: CHEMBL5098727

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2021
Volume: 64
Issue: 21.0
First Page: 16147
Last Page: 16158
DOI: 10.1021/acs.jmedchem.1c01459

Target ChEMBL ID: CHEMBL1075127
ChEMBL Target Name: Baculoviral IAP repeat-containing protein 7
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.05	IC50	=	50	nM
0.278	IC50	=	278	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：E3 ubiquitin-protein ligase XIAP

External ID: CHEMBL5098728

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2021
Volume: 64
Issue: 21.0
First Page: 16147
Last Page: 16158
DOI: 10.1021/acs.jmedchem.1c01459

Target ChEMBL ID: CHEMBL4198
ChEMBL Target Name: Inhibitor of apoptosis protein 3
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.262	IC50	=	262	nM
0.323	IC50	=	323	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Baculoviral IAP repeat-containing protein 2

External ID: CHEMBL5098729

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2021
Volume: 64
Issue: 21.0
First Page: 16147
Last Page: 16158
DOI: 10.1021/acs.jmedchem.1c01459

Target ChEMBL ID: CHEMBL5462
ChEMBL Target Name: Baculoviral IAP repeat-containing protein 2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.153	IC50	=	153	nM
0.266	IC50	=	266	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Baculoviral IAP repeat-containing protein 3

External ID: CHEMBL5098730

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2021
Volume: 64
Issue: 21.0
First Page: 16147
Last Page: 16158
DOI: 10.1021/acs.jmedchem.1c01459

Target ChEMBL ID: CHEMBL5335
ChEMBL Target Name: Baculoviral IAP repeat-containing protein 3
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.288	IC50	=	288	nM
0.397	IC50	=	397	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Baculoviral IAP repeat-containing protein 7

External ID: CHEMBL5098726

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2021
Volume: 64
Issue: 21.0
First Page: 16147
Last Page: 16158
DOI: 10.1021/acs.jmedchem.1c01459

Target ChEMBL ID: CHEMBL1075127
ChEMBL Target Name: Baculoviral IAP repeat-containing protein 7
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Delta Tm	=	12.6	degrees C
Delta Tm	=	28.7	degrees C

2865171-75-9 靶点实验数据