HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：BindingDB 靶标：N/A

External ID: BindingDB_3523_1

Protocol: N/A

Comment: Compounds with any of Ki, IC50, Kd, or EC50 activity value <= 10uM are labeled as "Active".
If multiple measurements are available for a given compound, it is labeled as "Active" if any of the measurements meet the criterion. Activity values are checked in the order of Ki, IC50, Kd, and EC50. The first entry that meets the above activity threshold is used to determine "Standard Type", "Standard Relation", and "PubChem Standard Value". Otherwise, the first non-empty entry will be used to set those values.

Standard Type	Standard Relation	PubChem Standard Value	Ki Qualifier	Ki	Target Accession(s)	Ligand	Target
Ki		0.189		189	P35367	BDBM35921	Histamine H1 receptor
Ki		0.54		540	P28223	BDBM35922	5-hydroxytryptamine receptor 2A
Ki	>	10	>	10000	P35367	BDBM35930	Histamine H1 receptor
Ki		7.356		7356	P28223	BDBM35931	5-hydroxytryptamine receptor 2A
Ki		5.172		5172	P35367	BDBM35931	Histamine H1 receptor
Ki	>	10	>	10000	P28223	BDBM35932	5-hydroxytryptamine receptor 2A
Ki		0.064		64	P35367	BDBM35933	Histamine H1 receptor
Ki		1.636		1636	P28223	BDBM35934	5-hydroxytryptamine receptor 2A
Ki		0.075		75	P35367	BDBM35934	Histamine H1 receptor
Ki		2.589		2589	P28223	BDBM35935	5-hydroxytryptamine receptor 2A
Ki		1.67		1670	P35367	BDBM35935	Histamine H1 receptor
Ki		0.754		754	P28223	BDBM35936	5-hydroxytryptamine receptor 2A
Ki		0.386		386	P35367	BDBM35936	Histamine H1 receptor
Ki		1.151		1151	P28223	BDBM35937	5-hydroxytryptamine receptor 2A

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Histamine H1 receptor

External ID: CHEMBL1073242

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2009
Volume: 17
Issue: 18
First Page: 6496
Last Page: 6504
DOI: 10.1016/j.bmc.2009.08.016

Target ChEMBL ID: CHEMBL231
ChEMBL Target Name: Histamine H1 receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.197	Ki	=	197	nM
0.189	Ki	=	189	nM
0.003	Ki	=	3	nM
1.67	Ki	=	1670	nM
0.386	Ki	=	386	nM
0.07	Ki	=	70	nM
0.048	Ki	=	48	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：5-hydroxytryptamine receptor 2A

External ID: CHEMBL1073241

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2009
Volume: 17
Issue: 18
First Page: 6496
Last Page: 6504
DOI: 10.1016/j.bmc.2009.08.016

Target ChEMBL ID: CHEMBL224
ChEMBL Target Name: Serotonin 2a (5-HT2a) receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.02	Ki	=	20	nM
0.052	Ki	=	52	nM
0.013	Ki	=	13	nM
2.589	Ki	=	2589	nM
0.754	Ki	=	754	nM
1.151	Ki	=	1151	nM
0.092	Ki	=	92	nM

28075-29-8 靶点实验数据