HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5511968

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2024
Volume: 67
Issue: 11
First Page: 8585
Last Page: 8608
DOI: 10.1021/acs.jmedchem.3c02203

Standard Type	Standard Relation	Standard Value
Fa	=	0.08
Fa	=	0.55

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5511967

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2024
Volume: 67
Issue: 11
First Page: 8585
Last Page: 8608
DOI: 10.1021/acs.jmedchem.3c02203

Standard Type	Standard Relation	Standard Value	Standard Units
F	=	2.7	%
F	=	46.5	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5511966

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2024
Volume: 67
Issue: 11
First Page: 8585
Last Page: 8608
DOI: 10.1021/acs.jmedchem.3c02203

Standard Type	Standard Relation	Standard Value	Standard Units
T1/2	=	3.8	hr
T1/2	=	2.3	hr

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5511965

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2024
Volume: 67
Issue: 11
First Page: 8585
Last Page: 8608
DOI: 10.1021/acs.jmedchem.3c02203

Standard Type	Standard Relation	Standard Value	Standard Units
Vd	=	0.9	L.kg-1
Vd	=	0.7	L.kg-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5511964

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2024
Volume: 67
Issue: 11
First Page: 8585
Last Page: 8608
DOI: 10.1021/acs.jmedchem.3c02203

Standard Type	Standard Relation	Standard Value	Standard Units
CL	=	57.7	mL.min-1.kg-1
CL	=	13.9	mL.min-1.kg-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5511962

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2024
Volume: 67
Issue: 11
First Page: 8585
Last Page: 8608
DOI: 10.1021/acs.jmedchem.3c02203

Standard Type	Standard Relation	Standard Value	Standard Units
PPB	=	60.1	%
PPB	=	99.7	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5511961

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2024
Volume: 67
Issue: 11
First Page: 8585
Last Page: 8608
DOI: 10.1021/acs.jmedchem.3c02203

Standard Type	Standard Relation	Standard Value	Standard Units
PPB	=	48.4	%
PPB	=	99.7	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5511960

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2024
Volume: 67
Issue: 11
First Page: 8585
Last Page: 8608
DOI: 10.1021/acs.jmedchem.3c02203

Standard Type	Standard Relation	Standard Value	Standard Units
Papp	=	0.7	10^-6 cm/s
Papp	=	8.9	10^-6 cm/s

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：von Hippel-Lindau disease tumor suppressor

External ID: CHEMBL5511957

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2024
Volume: 67
Issue: 11
First Page: 8585
Last Page: 8608
DOI: 10.1021/acs.jmedchem.3c02203

Target ChEMBL ID: CHEMBL3108660
ChEMBL Target Name: von Hippel-Lindau disease tumor suppressor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
2.4	Kd	=	2400	nM
0.16	Kd	=	160	nM
5.6	Kd	=	5600	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：von Hippel-Lindau disease tumor suppressor

External ID: CHEMBL5511956

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2024
Volume: 67
Issue: 11
First Page: 8585
Last Page: 8608
DOI: 10.1021/acs.jmedchem.3c02203

Target ChEMBL ID: CHEMBL3108660
ChEMBL Target Name: von Hippel-Lindau disease tumor suppressor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
6.6	Kd	=	6600	nM
0.13	Kd	=	130	nM
32.4	Kd	=	32400	nM

2771069-76-0 靶点实验数据