HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4410613

Protocol: N/A

Comment: Journal: Bioorg Med Chem
Year: 2019
Volume: 27
Issue: 24
First Page: 115158
Last Page: 115158
DOI: 10.1016/j.bmc.2019.115158

Standard Type	Standard Relation	Standard Value	Activity Comment
Ratio Ki	=	47.17
Ratio Ki	=	4.52

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：KB

External ID: CHEMBL701605

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2002
Volume: 45
Issue: 6
First Page: 1244
Last Page: 1252
DOI: 10.1021/jm010131q

Target ChEMBL ID: CHEMBL398
ChEMBL Target Name: KB
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
180	IC50	=	180000	nM	Outside typical range
50	IC50	>	50000	nM
72	IC50	=	72000	nM
46	IC50	=	46000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4410614

Protocol: N/A

Comment: Journal: Bioorg Med Chem
Year: 2019
Volume: 27
Issue: 24
First Page: 115158
Last Page: 115158
DOI: 10.1016/j.bmc.2019.115158

Standard Type	Standard Relation	Standard Value	Activity Comment
Ratio Ki	=	0.07
Ratio Ki	=	0.33

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Plasmodium falciparum

External ID: CHEMBL4410615

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem
Year: 2019
Volume: 27
Issue: 24
First Page: 115158
Last Page: 115158
DOI: 10.1016/j.bmc.2019.115158

Target ChEMBL ID: CHEMBL364
ChEMBL Target Name: Plasmodium falciparum
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
5.24	IC50	=	5240	nM
0.71	IC50	=	710	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：BC

External ID: CHEMBL651283

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2002
Volume: 45
Issue: 6
First Page: 1244
Last Page: 1252
DOI: 10.1021/jm010131q

Target ChEMBL ID: CHEMBL613535
ChEMBL Target Name: BC
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
56	IC50	=	56000	nM
16	IC50	=	16000	nM
32	IC50	=	32000	nM
25	IC50	=	25000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Plasmodium falciparum

External ID: CHEMBL4410616

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem
Year: 2019
Volume: 27
Issue: 24
First Page: 115158
Last Page: 115158
DOI: 10.1016/j.bmc.2019.115158

Target ChEMBL ID: CHEMBL364
ChEMBL Target Name: Plasmodium falciparum
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
31.1	IC50	=	31100	nM
5.24	IC50	=	5240	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Plasmodium falciparum

External ID: CHEMBL4410617

Protocol: N/A

Comment: Journal: Bioorg Med Chem
Year: 2019
Volume: 27
Issue: 24
First Page: 115158
Last Page: 115158
DOI: 10.1016/j.bmc.2019.115158

Target ChEMBL ID: CHEMBL364
ChEMBL Target Name: Plasmodium falciparum
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value
Ratio IC50	=	9

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Bifunctional dihydrofolate reductase-thymidylate synthase

External ID: CHEMBL849932

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2002
Volume: 45
Issue: 6
First Page: 1244
Last Page: 1252
DOI: 10.1021/jm010131q

Target ChEMBL ID: CHEMBL1939
ChEMBL Target Name: Dihydrofolate reductase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Relation	Standard Value
Ratio	=	89.8
Ratio	=	147.7
Ratio	=	35.4
Ratio	=	3.8
Ratio	=	95.6
Ratio	=	10.8
Ratio		12.6
Ratio	=	71
Ratio	=	2.3
Ratio	=	3.4
Ratio	=	231.6
Ratio	=	1.8
Ratio	=	1.6
Ratio	=	5
Ratio	=	31.5

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Plasmodium falciparum

External ID: CHEMBL4410618

Protocol: N/A

Comment: Journal: Bioorg Med Chem
Year: 2019
Volume: 27
Issue: 24
First Page: 115158
Last Page: 115158
DOI: 10.1016/j.bmc.2019.115158

Target ChEMBL ID: CHEMBL364
ChEMBL Target Name: Plasmodium falciparum
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value
Ratio IC50	>	0.5

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Vero

External ID: CHEMBL4410619

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem
Year: 2019
Volume: 27
Issue: 24
First Page: 115158
Last Page: 115158
DOI: 10.1016/j.bmc.2019.115158

Target ChEMBL ID: CHEMBL391
ChEMBL Target Name: Vero
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
7.21	IC50	=	7210	nM
50	IC50	>	50000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4410606

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem
Year: 2019
Volume: 27
Issue: 24
First Page: 115158
Last Page: 115158
DOI: 10.1016/j.bmc.2019.115158

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
5.5E-4	Ki	=	0.55	nM
0.00148	Ki	=	1.48	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4410607

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem
Year: 2019
Volume: 27
Issue: 24
First Page: 115158
Last Page: 115158
DOI: 10.1016/j.bmc.2019.115158

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.0032	Ki	=	3.2	nM
0.01708	Ki	=	17.08	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Bifunctional dihydrofolate reductase-thymidylate synthase

External ID: CHEMBL667200

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2004
Volume: 47
Issue: 3
First Page: 673
Last Page: 680
DOI: 10.1021/jm030165t

Target ChEMBL ID: CHEMBL1939
ChEMBL Target Name: Dihydrofolate reductase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.0069	Ki	=	6.9	nM
0.003	Ki	=	3	nM
0.0031	Ki	=	3.1	nM
0.0033	Ki	=	3.3	nM
7.7E-4	Ki	=	0.77	nM
0.0314	Ki	=	31.4	nM
0.111	Ki	=	111	nM
0.134	Ki	=	134	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4410608

Protocol: N/A

Comment: Journal: Bioorg Med Chem
Year: 2019
Volume: 27
Issue: 24
First Page: 115158
Last Page: 115158
DOI: 10.1016/j.bmc.2019.115158

Standard Type	Standard Relation	Standard Value
Ratio Ki	=	3.83

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Bifunctional dihydrofolate reductase-thymidylate synthase

External ID: CHEMBL880697

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2004
Volume: 47
Issue: 3
First Page: 673
Last Page: 680
DOI: 10.1021/jm030165t

Target ChEMBL ID: CHEMBL1939
ChEMBL Target Name: Dihydrofolate reductase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.284	Ki	=	284	nM
0.032	Ki	=	32	nM
0.053	Ki	=	53	nM
0.024	Ki	=	24	nM
0.0027	Ki	=	2.7	nM
0.42	Ki	=	420	nM
0.984	Ki	=	984	nM
2.427	Ki	=	2427	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Bifunctional dihydrofolate reductase-thymidylate synthase

External ID: CHEMBL848232

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2002
Volume: 45
Issue: 6
First Page: 1244
Last Page: 1252
DOI: 10.1021/jm010131q

Target ChEMBL ID: CHEMBL1939
ChEMBL Target Name: Dihydrofolate reductase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Relation	Standard Value
Ratio	=	47.7
Ratio	=	105
Ratio	=	8.5
Ratio	=	2
Ratio	=	43.3
Ratio	=	7.9
Ratio	=	9
Ratio	=	51.8
Ratio	=	4
Ratio	=	2.3
Ratio	=	153.6
Ratio	=	1.9
Ratio	=	1.7
Ratio	=	4.2
Ratio	=	15.6

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4410609

Protocol: N/A

Comment: Journal: Bioorg Med Chem
Year: 2019
Volume: 27
Issue: 24
First Page: 115158
Last Page: 115158
DOI: 10.1016/j.bmc.2019.115158

Standard Type	Standard Relation	Standard Value
Ratio Ki	=	641.67
Ratio Ki	=	13.87

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4410610

Protocol: N/A

Comment: Journal: Bioorg Med Chem
Year: 2019
Volume: 27
Issue: 24
First Page: 115158
Last Page: 115158
DOI: 10.1016/j.bmc.2019.115158

Standard Type	Standard Relation	Standard Value
Ratio Ki	=	0.083

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Bifunctional dihydrofolate reductase-thymidylate synthase

External ID: CHEMBL668409

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2002
Volume: 45
Issue: 6
First Page: 1244
Last Page: 1252
DOI: 10.1021/jm010131q

Target ChEMBL ID: CHEMBL1939
ChEMBL Target Name: Dihydrofolate reductase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.0147	Ki	=	14.7	nM
0.0443	Ki	=	44.3	nM
0.0035	Ki	=	3.5	nM
0.0052	Ki	=	5.2	nM
0.7301	Ki	=	730.1	nM
0.0097	Ki	=	9.7	nM
0.0126	Ki	=	12.6	nM
7.0E-4	Ki	=	0.7	nM
0.0367	Ki	=	36.7	nM
0.5558	Ki	=	555.8	nM
0.0028	Ki	=	2.8	nM
0.5345	Ki	=	534.5	nM
0.0031	Ki	=	3.1	nM
0.0391	Ki	=	39.1	nM
0.0423	Ki	=	42.3	nM
0.0346	Ki	=	34.6	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Bifunctional dihydrofolate reductase-thymidylate synthase

External ID: CHEMBL668410

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2002
Volume: 45
Issue: 6
First Page: 1244
Last Page: 1252
DOI: 10.1021/jm010131q

Target ChEMBL ID: CHEMBL1939
ChEMBL Target Name: Dihydrofolate reductase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.0106	Ki	=	10.6	nM
0.0315	Ki	=	31.5	nM
0.0016	Ki	=	1.6	nM
0.0033	Ki	=	3.3	nM
0.4213	Ki	=	421.3	nM
0.0071	Ki	=	7.1	nM
0.009	Ki	=	9	nM
0.0012	Ki	=	1.2	nM
0.0256	Ki	=	25.6	nM
0.3687	Ki	=	368.7	nM
0.0017	Ki	=	1.7	nM
0.4152	Ki	=	415.2	nM
0.0032	Ki	=	3.2	nM
0.0235	Ki	=	23.5	nM
0.0209	Ki	=	20.9	nM
0.0172	Ki	=	17.2	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Dihydrofolate reductase

External ID: CHEMBL4410612

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem
Year: 2019
Volume: 27
Issue: 24
First Page: 115158
Last Page: 115158
DOI: 10.1016/j.bmc.2019.115158

Target ChEMBL ID: CHEMBL202
ChEMBL Target Name: Dihydrofolate reductase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
0.01841	Ki	=	18.41	nM
0.55555	Ki	=	555.55	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Bifunctional dihydrofolate reductase-thymidylate synthase

External ID: CHEMBL668411

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2002
Volume: 45
Issue: 6
First Page: 1244
Last Page: 1252
DOI: 10.1021/jm010131q

Target ChEMBL ID: CHEMBL1939
ChEMBL Target Name: Dihydrofolate reductase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
4.0E-4	Ki	=	0.4	nM
3.0E-4	Ki	=	0.3	nM
4.0E-4	Ki	=	0.4	nM
0.0013	Ki	=	1.3	nM
0.188	Ki	=	188	nM
9.0E-4	Ki	=	0.9	nM
0.001	Ki	=	1	nM
3.0E-4	Ki	=	0.3	nM
0.0109	Ki	=	10.9	nM
0.0024	Ki	=	2.4	nM
5.0E-4	Ki	=	0.5	nM
0.007	Ki	=	7	nM
0.0019	Ki	=	1.9	nM
9.0E-4	Ki	=	0.9	nM
0.001	Ki	=	1	nM
0.0011	Ki	=	1.1	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Plasmodium yoelii

External ID: CHEMBL1789905

Protocol: N/A

Comment: Journal: Science
Year: 2011
Volume: 334
Issue: 6061
First Page: 1372
Last Page: 1377
DOI: 10.1126/science.1211936

Target ChEMBL ID: CHEMBL612889
ChEMBL Target Name: Plasmodium yoelii
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Inactive
Activity	Inactive
Activity	Inactive
Activity	Inactive
Activity	Inactive
Activity	Inactive
Activity	Inactive
Activity	Active
Activity	Inactive
Activity	Inactive
Activity	Active
Activity	Inactive
Activity	Active
Activity	Active
Activity	Active
Activity	Inactive
Activity	Inactive
Activity	Inactive
Activity	Inactive
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Bifunctional dihydrofolate reductase-thymidylate synthase

External ID: CHEMBL663728

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2004
Volume: 47
Issue: 3
First Page: 673
Last Page: 680
DOI: 10.1021/jm030165t

Target ChEMBL ID: CHEMBL1939
ChEMBL Target Name: Dihydrofolate reductase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.088	Ki	=	88	nM
0.025	Ki	=	25	nM
0.041	Ki	=	41	nM
0.015	Ki	=	15	nM
0.0018	Ki	=	1.8	nM
0.285	Ki	=	285	nM
0.217	Ki	=	217	nM
1.582	Ki	=	1582	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Bifunctional dihydrofolate reductase-thymidylate synthase

External ID: CHEMBL847344

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2004
Volume: 47
Issue: 3
First Page: 673
Last Page: 680
DOI: 10.1021/jm030165t

Target ChEMBL ID: CHEMBL1939
ChEMBL Target Name: Dihydrofolate reductase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Relation	Standard Value
Ratio	=	8.3
Ratio	=	641.7
Ratio	=	13.9
Ratio	=	53
Ratio	=	4.7
Ratio	=	7.4
Ratio	=	244.5
Ratio	=	280

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Bifunctional dihydrofolate reductase-thymidylate synthase

External ID: CHEMBL847343

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2004
Volume: 47
Issue: 3
First Page: 673
Last Page: 680
DOI: 10.1021/jm030165t

Target ChEMBL ID: CHEMBL1939
ChEMBL Target Name: Dihydrofolate reductase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Relation	Standard Value
Ratio	=	0.7
Ratio	=	111.8
Ratio	=	1.3
Ratio	=	3.1
Ratio	=	1.3
Ratio	=	3.4
Ratio	=	7.5
Ratio	=	20.9

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Bifunctional dihydrofolate reductase-thymidylate synthase

External ID: CHEMBL847342

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2004
Volume: 47
Issue: 3
First Page: 673
Last Page: 680
DOI: 10.1021/jm030165t

Target ChEMBL ID: CHEMBL1939
ChEMBL Target Name: Dihydrofolate reductase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Relation	Standard Value
Ratio	=	4.7
Ratio	=	186.7
Ratio	=	10.9
Ratio	=	41
Ratio	=	2.3
Ratio	=	5.2
Ratio	=	110
Ratio	=	190

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL881626

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2002
Volume: 45
Issue: 6
First Page: 1244
Last Page: 1252
DOI: 10.1021/jm010131q

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value
Safety ratio	>	714
Safety ratio	=	4466

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL849533

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2002
Volume: 45
Issue: 6
First Page: 1244
Last Page: 1252
DOI: 10.1021/jm010131q

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value
Safety ratio	>	151
Safety ratio	=	206

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Bifunctional dihydrofolate reductase-thymidylate synthase

External ID: CHEMBL668423

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2002
Volume: 45
Issue: 6
First Page: 1244
Last Page: 1252
DOI: 10.1021/jm010131q

Target ChEMBL ID: CHEMBL1939
ChEMBL Target Name: Dihydrofolate reductase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Relation	Standard Value
Relative activity	=	1
Relative activity	=	0.2
Relative activity	=	1.4

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：BindingDB 靶标：N/A

External ID: BindingDB_2268_1

Protocol: N/A

Comment: Compounds with any of Ki, IC50, Kd, or EC50 activity value <= 10uM are labeled as "Active".
If multiple measurements are available for a given compound, it is labeled as "Active" if any of the measurements meet the criterion. Activity values are checked in the order of Ki, IC50, Kd, and EC50. The first entry that meets the above activity threshold is used to determine "Standard Type", "Standard Relation", and "PubChem Standard Value". Otherwise, the first non-empty entry will be used to set those values.

Standard Type	PubChem Standard Value	Ki	IC50 Qualifier	IC50	Target Accession(s)	Ligand	Target
Ki	0.00342	3.42		1520	O02604	BDBM18774	Bifunctional dihydrofolate reductase-thymidylate synthase
Ki	1.07593	1075.93	>	50000	O02604	BDBM18774	Bifunctional dihydrofolate reductase-thymidylate synthase [1-238,S58R,S117N]
Ki	7.8E-4	0.78		1950	O02604	BDBM18775	Bifunctional dihydrofolate reductase-thymidylate synthase
Ki	0.0634	63.4	>	50000	O02604	BDBM18775	Bifunctional dihydrofolate reductase-thymidylate synthase [1-238,S58R,S117N]
Ki	0.0014	1.4		220	O02604	BDBM18776	Bifunctional dihydrofolate reductase-thymidylate synthase
Ki	0.02807	28.07		18220	O02604	BDBM18776	Bifunctional dihydrofolate reductase-thymidylate synthase [1-238,S58R,S117N]
Ki	7.8E-4	0.78		90	O02604	BDBM18781	Bifunctional dihydrofolate reductase-thymidylate synthase
Ki	0.00659	6.59		30050	O02604	BDBM18781	Bifunctional dihydrofolate reductase-thymidylate synthase [1-238,S58R,S117N]
Ki	0.00114	1.14		1760	O02604	BDBM18782	Bifunctional dihydrofolate reductase-thymidylate synthase
Ki	0.04749	47.49	>	50000	O02604	BDBM18782	Bifunctional dihydrofolate reductase-thymidylate synthase [1-238,S58R,S117N]
Ki	3.1E-4	0.31		360	O02604	BDBM18784	Bifunctional dihydrofolate reductase-thymidylate synthase
Ki	5.4E-4	0.54		300	O02604	BDBM18784	Bifunctional dihydrofolate reductase-thymidylate synthase [1-238,S58R,S117N]
Ki	7.7E-4	0.77		2380	O02604	BDBM18786	Bifunctional dihydrofolate reductase-thymidylate synthase
Ki	0.00132	1.32		13890	O02604	BDBM18786	Bifunctional dihydrofolate reductase-thymidylate synthase [1-238,S58R,S117N]
Ki	0.00418	4.18		11330	O02604	BDBM18789	Bifunctional dihydrofolate reductase-thymidylate synthase
Ki	0.02247	22.47		12850	O02604	BDBM18789	Bifunctional dihydrofolate reductase-thymidylate synthase [1-238,S58R,S117N]
IC50	0.23			230	O02604	BDBM18790	Bifunctional dihydrofolate reductase-thymidylate synthase
Ki	9.0E-4	0.9		3020	O02604	BDBM18790	Bifunctional dihydrofolate reductase-thymidylate synthase [1-238,S58R,S117N]
Ki	5.3E-4	0.53		800	O02604	BDBM18791	Bifunctional dihydrofolate reductase-thymidylate synthase
Ki	8.1E-4	0.81		2760	O02604	BDBM18791	Bifunctional dihydrofolate reductase-thymidylate synthase [1-238,S58R,S117N]

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL849536

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2002
Volume: 45
Issue: 6
First Page: 1244
Last Page: 1252
DOI: 10.1021/jm010131q

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value
Safety ratio	=	1362.5
Safety ratio	>	3125
Safety ratio	>	714
Safety ratio	=	94
Safety ratio	=	1883

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL849535

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2002
Volume: 45
Issue: 6
First Page: 1244
Last Page: 1252
DOI: 10.1021/jm010131q

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value
Safety ratio	=	3.5
Safety ratio	>	8.1
Safety ratio	>	151
Safety ratio	=	87

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Glucose transporter

External ID: CHEMBL3436044

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL3431938
ChEMBL Target Name: Glucose transporter
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: St. Jude Childrenâ€™s Research Hospital Leishmania Screening

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	6.02	%
Inhibition	=	1.08	%
Inhibition	=	3.62	%
Inhibition	=	-0.55	%
Inhibition	=	-2.13	%
Inhibition	=	-1.54	%
Inhibition	=	0.73	%
Inhibition	=	0.63	%
Inhibition	=	-1.34	%
Inhibition	=	2.77	%
Inhibition	=	-5.87	%
Inhibition	=	8.94	%
Inhibition	=	2.88	%
Inhibition	=	0.77	%
Inhibition	=	-0.15	%
Inhibition	=	4.63	%
Inhibition	=	2.43	%
Inhibition	=	-1.72	%
Inhibition	=	-0.85	%
Inhibition	=	2.22	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL849542

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2002
Volume: 45
Issue: 6
First Page: 1244
Last Page: 1252
DOI: 10.1021/jm010131q

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value
Safety ratio	=	1.03
Safety ratio	=	96
Safety ratio		41

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Bifunctional dihydrofolate reductase-thymidylate synthase

External ID: CHEMBL667612

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2002
Volume: 45
Issue: 6
First Page: 1244
Last Page: 1252
DOI: 10.1021/jm010131q

Target ChEMBL ID: CHEMBL1939
ChEMBL Target Name: Dihydrofolate reductase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Relation	Standard Value
Relative activity	=	0.5
Relative activity	=	3.8
Relative activity	=	1.5

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Plasmodium falciparum

External ID: CHEMBL1040691

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Proc Natl Acad Sci U S A
Year: 2008
Volume: 105
Issue: 26
First Page: 9059
Last Page: 9064
DOI: 10.1073/pnas.0802982105

Target ChEMBL ID: CHEMBL364
ChEMBL Target Name: Plasmodium falciparum
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Data Source: Novartis Malaria Screening

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.2485	EC50	=	248.5	nM
0.0688	EC50	=	68.8	nM
0.0744	EC50	=	74.4	nM
0.2605	EC50	=	260.5	nM
0.364	EC50	=	364	nM
0.342	EC50	=	342	nM
0.441	EC50	=	441	nM
0.652	EC50	=	652	nM
0.0977	EC50	=	97.7	nM
0.2631	EC50	=	263.1	nM
0.352	EC50	=	352	nM
0.01413	EC50	=	14.13	nM
1.099	EC50	=	1099	nM
0.2072	EC50	=	207.2	nM
0.0825	EC50	=	82.5	nM
0.0404	EC50	=	40.4	nM
0.0831	EC50	=	83.1	nM
0.7	EC50	=	700	nM
0.1714	EC50	=	171.4	nM
0.1067	EC50	=	106.7	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Solute carrier family 2, facilitated glucose transporter member 1

External ID: CHEMBL3436042

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL2535
ChEMBL Target Name: Glucose transporter
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Data Source: St. Jude Childrenâ€™s Research Hospital Leishmania Screening

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	10.68	%
Inhibition	=	3.27	%
Inhibition	=	2.26	%
Inhibition	=	17.48	%
Inhibition	=	1.41	%
Inhibition	=	8.17	%
Inhibition	=	5.47	%
Inhibition	=	2.31	%
Inhibition	=	3.05	%
Inhibition	=	3.73	%
Inhibition	=	5.67	%
Inhibition	=	0.14	%
Inhibition	=	1.93	%
Inhibition	=	16.24	%
Inhibition	=	1.51	%
Inhibition	=	7.91	%
Inhibition	=	6.9	%
Inhibition	=	1.69	%
Inhibition	=	75.77	%
Inhibition	=	96.79	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Hexose transporter 1

External ID: CHEMBL3436043

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL4697
ChEMBL Target Name: Hexose transporter 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Data Source: St. Jude Childrenâ€™s Research Hospital Leishmania Screening

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	-1.2	%
Inhibition	=	6.76	%
Inhibition	=	14.6	%
Inhibition	=	0.38	%
Inhibition	=	5.62	%
Inhibition	=	10.22	%
Inhibition	=	1.73	%
Inhibition	=	1.53	%
Inhibition	=	2.85	%
Inhibition	=	0.24	%
Inhibition	=	2.22	%
Inhibition	=	3.5	%
Inhibition	=	4.54	%
Inhibition	=	0.98	%
Inhibition	=	5.18	%
Inhibition	=	-2.18	%
Inhibition	=	1.23	%
Inhibition	=	0.63	%
Inhibition	=	8.47	%
Inhibition	=	1.71	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Plasmodium falciparum

External ID: CHEMBL849545

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2002
Volume: 45
Issue: 6
First Page: 1244
Last Page: 1252
DOI: 10.1021/jm010131q

Target ChEMBL ID: CHEMBL364
ChEMBL Target Name: Plasmodium falciparum
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value
Safety ratio	>	7.5
Safety ratio	=	400
Safety ratio	=	444
Safety ratio	>	532
Safety ratio	=	200
Safety ratio	=	857

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Bifunctional dihydrofolate reductase-thymidylate synthase

External ID: CHEMBL828776

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2004
Volume: 47
Issue: 17
First Page: 4258
Last Page: 4267
DOI: 10.1021/jm040769c

Target ChEMBL ID: CHEMBL1939
ChEMBL Target Name: Dihydrofolate reductase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.14	Ki	=	140	nM
0.09	Ki	=	90	nM
8.7E-4	Ki	=	0.87	nM
7.7E-4	Ki	=	0.77	nM
0.0011	Ki	=	1.1	nM
8.4E-4	Ki	=	0.84	nM
0.0013	Ki	=	1.3	nM
0.09	Ki	=	90	nM
0.013	Ki	=	13	nM
0.01	Ki	=	10	nM
0.11	Ki	=	110	nM
7.4E-4	Ki	=	0.74	nM
0.037	Ki	=	37	nM
0.1	Ki	=	100	nM
0.083	Ki	=	83	nM
0.072	Ki	=	72	nM
0.0011	Ki	=	1.1	nM
0.085	Ki	=	85	nM
0.088	Ki	=	88	nM
1.4	Ki	=	1400	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1040694

Protocol: N/A

Comment: Journal: Proc Natl Acad Sci U S A
Year: 2008
Volume: 105
Issue: 26
First Page: 9059
Last Page: 9064
DOI: 10.1073/pnas.0802982105

Data Source: Novartis Malaria Screening

Standard Type	Standard Relation	Standard Value	Standard Units
IFI	=	12.4	%
IFI	=	0	%
IFI	=	4.118	%
IFI	=	6.952	%
IFI	=	2.614	%
IFI	=	1.163	%
IFI	=	6.061	%
IFI	=	1.84	%
IFI	=	1.613	%
IFI	=	0	%
IFI	=	22.64	%
IFI	=	1.075	%
IFI	=	0	%
IFI	=	14.16	%
IFI	=	0	%
IFI	=	0.7812	%
IFI	=	3.937	%
IFI	=	3.876	%
IFI	=	7.092	%
IFI	=	0.5495	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Plasmodium falciparum

External ID: CHEMBL1040692

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Proc Natl Acad Sci U S A
Year: 2008
Volume: 105
Issue: 26
First Page: 9059
Last Page: 9064
DOI: 10.1073/pnas.0802982105

Target ChEMBL ID: CHEMBL364
ChEMBL Target Name: Plasmodium falciparum
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Data Source: Novartis Malaria Screening

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.01422	EC50	=	14.22	nM
0.0687	EC50	=	68.7	nM
0.0837	EC50	=	83.7	nM
0.46	EC50	=	460	nM
0.442	EC50	=	442	nM
0.766	EC50	=	766	nM
1.655	EC50	=	1655	nM
0.1708	EC50	=	170.8	nM
0.958	EC50	=	958	nM
0.338	EC50	=	338	nM
0.3142	EC50	=	314.2	nM
0.627	EC50	=	627	nM
0.0841	EC50	=	84.1	nM
0.711	EC50	=	711	nM
0.2319	EC50	=	231.9	nM
0.547	EC50	=	547	nM
0.366	EC50	=	366	nM
0.1165	EC50	=	116.5	nM
1.25	EC50	>	1250	nM
1.601	EC50	=	1601	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Huh-7

External ID: CHEMBL1040693

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Proc Natl Acad Sci U S A
Year: 2008
Volume: 105
Issue: 26
First Page: 9059
Last Page: 9064
DOI: 10.1073/pnas.0802982105

Target ChEMBL ID: CHEMBL614039
ChEMBL Target Name: Huh-7
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Data Source: Novartis Malaria Screening

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
19.61	CC50	=	19610	nM
6.25	CC50	>	6250	nM
12.42	CC50	=	12420	nM
20.22	CC50	=	20220	nM
100	CC50	>	100000	nM
100	CC50	>	100000	nM
8.94	CC50	=	8940	nM
1.587	CC50	=	1587	nM
100	CC50	>	100000	nM
25.8	CC50	=	25800	nM
0.835	CC50	=	835	nM
100	CC50	>	100000	nM
100	CC50	>	100000	nM
10	CC50	>	10000	nM
100	CC50	>	100000	nM
93.22	CC50	>	93220	nM
13.11	CC50	=	13110	nM
28.86	CC50	=	28860	nM
	CC50				Not Determined
37.19	CC50	=	37190	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：1187 靶标：Calcium-Dependent Protein Kinase 1 (CDPK1)

External ID: PfalCDPK1

Protocol: The kinase's catalytic activity was measured with an ATP depletion assay. A luciferase-based reagent, Kinase-Glo, was used to measure the [ATP] remaining after each incubation period.

Comment:

CDPK1_IC50_uM
0.103
0.235
0.402
0.798

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：1187 靶标：Protein Kinase 7 (PK7)

External ID: PfalPK7

Protocol: The kinase's catalytic activity was measured with an ATP depletion assay. A luciferase-based reagent, Kinase-Glo, was used to measure the [ATP] remaining after each incubation period.

Comment:

PK7_IC50_uM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Vero

External ID: CHEMBL845118

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2002
Volume: 45
Issue: 6
First Page: 1244
Last Page: 1252
DOI: 10.1021/jm010131q

Target ChEMBL ID: CHEMBL391
ChEMBL Target Name: Vero
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
50	IC50	>	50000	nM
200	IC50	=	200000	nM	Outside typical range
7	IC50	=	7000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：1187 靶标：Protein Kinase 6 (PK6)

External ID: PfalPK6

Protocol: The kinase's catalytic activity was measured with an ATP depletion assay. A luciferase-based reagent, Kinase-Glo, was used to measure the [ATP] remaining after each incubation period.

Comment:

PK6_IC50_uM
0.151
0.181
0.229
0.375

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：1187 靶标：mitogen-activated protein kinase 2 (MAP2 or MAPK2)

External ID: PfalMAPK2

Protocol: The kinase's catalytic activity was measured with an ATP depletion assay. A luciferase-based reagent, Kinase-Glo, was used to measure the [ATP] remaining after each incubation period.

Comment:

ACTIVITY_COMMENT

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：1187 靶标：Calcium-Dependent Protein Kinase 4 (CDPK4)

External ID: PfalCDPK4

Protocol: The kinase's catalytic activity was measured with an ATP depletion assay. A luciferase-based reagent, Kinase-Glo, was used to measure the [ATP] remaining after each incubation period.

Comment:

CDPK4_IC50_uM

27653-49-2 靶点实验数据