HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Beta-secretase 1

External ID: CHEMBL1048416

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2010
Volume: 53
Issue: 3
First Page: 951
Last Page: 965
DOI: 10.1021/jm901408p

Target ChEMBL ID: CHEMBL4822
ChEMBL Target Name: Beta-secretase 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
7	IC50	=	7000	nM
2.1	IC50	=	2100	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cathepsin D

External ID: CHEMBL1071582

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2010
Volume: 18
Issue: 2
First Page: 630
Last Page: 639
DOI: 10.1016/j.bmc.2009.12.007

Target ChEMBL ID: CHEMBL2581
ChEMBL Target Name: Cathepsin D
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
2.6	IC50	=	2600	nM
30	IC50	=	30000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4364237

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2019
Volume: 29
Issue: 24
First Page: 126772
Last Page: 126772
DOI: 10.1016/j.bmcl.2019.126772

Standard Type	Standard Relation	Standard Value
LogP	=	1.9
LogP	=	2.04

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Beta-secretase 1

External ID: CHEMBL4364236

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem Lett
Year: 2019
Volume: 29
Issue: 24
First Page: 126772
Last Page: 126772
DOI: 10.1016/j.bmcl.2019.126772

Target ChEMBL ID: CHEMBL4822
ChEMBL Target Name: Beta-secretase 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
10	IC50	>	10000	nM
1.109	IC50	=	1109	nM
0.1953	IC50	=	195.3	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Beta-secretase 1

External ID: CHEMBL4364235

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2019
Volume: 29
Issue: 24
First Page: 126772
Last Page: 126772
DOI: 10.1016/j.bmcl.2019.126772

Target ChEMBL ID: CHEMBL4822
ChEMBL Target Name: Beta-secretase 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	62.19	%
Inhibition	=	94.22	%
Inhibition	=	33.13	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cathepsin D

External ID: CHEMBL1048423

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2010
Volume: 53
Issue: 3
First Page: 951
Last Page: 965
DOI: 10.1021/jm901408p

Target ChEMBL ID: CHEMBL2581
ChEMBL Target Name: Cathepsin D
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	38	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL1048421

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2010
Volume: 53
Issue: 3
First Page: 951
Last Page: 965
DOI: 10.1021/jm901408p

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
AUC	=	1326.6	ng.hr.mL-1	standard_value was converted from uM.hr to ng.hr.mL-1 using the parent compound MW
AUC	=	319.49	ng.hr.mL-1	standard_value was converted from uM.hr to ng.hr.mL-1 using the parent compound MW

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1048419

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2010
Volume: 53
Issue: 3
First Page: 951
Last Page: 965
DOI: 10.1021/jm901408p

Standard Type	Standard Relation	Standard Value
Ratio	=	1.8
Ratio	=	0.9

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1273987

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2010
Volume: 20
Issue: 22
First Page: 6597
Last Page: 6605
DOI: 10.1016/j.bmcl.2010.09.029

Standard Type	Standard Relation	Standard Value
Ratio AUC	=	0.8
Ratio AUC	=	1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Beta-secretase 1

External ID: CHEMBL1664806

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur. J. Med. Chem.
Year: 2011
Volume: 46
Issue: 1
First Page: 58
Last Page: 64
DOI: 10.1016/j.ejmech.2010.10.014

Target ChEMBL ID: CHEMBL4822
ChEMBL Target Name: Beta-secretase 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.33037	IC50	=	330.37	nM
0.87096	IC50	=	870.96	nM
0.13002	IC50	=	130.02	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Beta-secretase 1

External ID: CHEMBL1042914

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2010
Volume: 20
Issue: 2
First Page: 632
Last Page: 635
DOI: 10.1016/j.bmcl.2009.11.052

Target ChEMBL ID: CHEMBL4822
ChEMBL Target Name: Beta-secretase 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
38	IC50	=	38000	nM
1.08	IC50	=	1080	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL723833

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1991
Volume: 34
Issue: 6
First Page: 1845
Last Page: 1849
DOI: 10.1021/jm00110a013

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Units	Activity Comment
ED50	mg.kg-1	Not Determined
ED50	mg.kg-1	Not Determined
ED50	mg.kg-1	Not Determined

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Beta-secretase 2

External ID: CHEMBL1042915

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2010
Volume: 20
Issue: 2
First Page: 632
Last Page: 635
DOI: 10.1016/j.bmcl.2009.11.052

Target ChEMBL ID: CHEMBL2525
ChEMBL Target Name: Beta secretase 2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.57	IC50	=	570	nM
0.41	IC50	=	410	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Beta-secretase 1

External ID: CHEMBL1115167

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2010
Volume: 20
Issue: 7
First Page: 2326
Last Page: 2329
DOI: 10.1016/j.bmcl.2010.01.136

Target ChEMBL ID: CHEMBL4822
ChEMBL Target Name: Beta-secretase 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.13	IC50	=	130	nM
0.06	IC50	=	60	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL719691

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1991
Volume: 34
Issue: 6
First Page: 1845
Last Page: 1849
DOI: 10.1021/jm00110a013

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Units	Activity Comment
ED50	mg.kg-1	Not Determined
ED50	mg.kg-1	Not Determined
ED50	mg.kg-1	Not Determined

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL723476

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1991
Volume: 34
Issue: 6
First Page: 1845
Last Page: 1849
DOI: 10.1021/jm00110a013

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Units	Activity Comment
ED50	mg.kg-1	Not Determined
ED50	mg.kg-1	Not Determined
ED50	mg.kg-1	Not Determined

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL719693

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1991
Volume: 34
Issue: 6
First Page: 1845
Last Page: 1849
DOI: 10.1021/jm00110a013

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Units	Activity Comment
ED50	mg.kg-1	Not Determined
ED50	mg.kg-1	Not Determined
ED50	mg.kg-1	Not Determined

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Beta-secretase 1

External ID: CHEMBL1044552

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2010
Volume: 53
Issue: 3
First Page: 1146
Last Page: 1158
DOI: 10.1021/jm901414e

Target ChEMBL ID: CHEMBL4822
ChEMBL Target Name: Beta-secretase 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.044	EC50	=	44	nM
0.07	EC50	=	70	nM
1.2	EC50	=	1200	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Beta-secretase 1

External ID: CHEMBL1044549

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2010
Volume: 53
Issue: 3
First Page: 1146
Last Page: 1158
DOI: 10.1021/jm901414e

Target ChEMBL ID: CHEMBL4822
ChEMBL Target Name: Beta-secretase 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.16	IC50	=	160	nM
0.07	IC50	=	70	nM
0.33	IC50	=	330	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1042920

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2010
Volume: 20
Issue: 2
First Page: 632
Last Page: 635
DOI: 10.1016/j.bmcl.2009.11.052

Standard Type	Standard Relation	Standard Value	Standard Units
permeability	=	11.1	10'-6 cm/s
permeability	=	8.6	10'-6 cm/s

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Beta-secretase 2

External ID: CHEMBL1044550

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2010
Volume: 53
Issue: 3
First Page: 1146
Last Page: 1158
DOI: 10.1021/jm901414e

Target ChEMBL ID: CHEMBL2525
ChEMBL Target Name: Beta secretase 2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.23	IC50	=	230	nM
2.53	IC50	=	2530	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1042921

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2010
Volume: 20
Issue: 2
First Page: 632
Last Page: 635
DOI: 10.1016/j.bmcl.2009.11.052

Standard Type	Standard Relation	Standard Value	Standard Units
Solubility	>	100	ug.mL-1
Solubility	=	55	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cathepsin D

External ID: CHEMBL1042918

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2010
Volume: 20
Issue: 2
First Page: 632
Last Page: 635
DOI: 10.1016/j.bmcl.2009.11.052

Target ChEMBL ID: CHEMBL2581
ChEMBL Target Name: Cathepsin D
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	34	%
Inhibition	=	2	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1042919

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2010
Volume: 20
Issue: 2
First Page: 632
Last Page: 635
DOI: 10.1016/j.bmcl.2009.11.052

Standard Type	Standard Relation	Standard Value	Standard Units
permeability	=	3	10'-6 cm/s
permeability	=	1	10'-6 cm/s

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Amyloid-beta precursor protein

External ID: CHEMBL1042916

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem Lett
Year: 2010
Volume: 20
Issue: 2
First Page: 632
Last Page: 635
DOI: 10.1016/j.bmcl.2009.11.052

Target ChEMBL ID: CHEMBL2487
ChEMBL Target Name: Amyloid-beta A4 protein
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
1.03	EC50	=	1030	nM
0.18	EC50	=	180	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Beta-secretase 2

External ID: CHEMBL1071579

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2010
Volume: 18
Issue: 2
First Page: 630
Last Page: 639
DOI: 10.1016/j.bmc.2009.12.007

Target ChEMBL ID: CHEMBL2525
ChEMBL Target Name: Beta secretase 2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.78	IC50	=	780	nM
2.01	IC50	=	2010	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cathepsin D

External ID: CHEMBL1045351

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2010
Volume: 53
Issue: 3
First Page: 1146
Last Page: 1158
DOI: 10.1021/jm901414e

Target ChEMBL ID: CHEMBL2581
ChEMBL Target Name: Cathepsin D
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	13	%
Inhibition	=	36	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Beta-secretase 1

External ID: CHEMBL1071577

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2010
Volume: 18
Issue: 2
First Page: 630
Last Page: 639
DOI: 10.1016/j.bmc.2009.12.007

Target ChEMBL ID: CHEMBL4822
ChEMBL Target Name: Beta-secretase 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.02	IC50	=	20	nM
2.68	IC50	=	2680	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1044555

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2010
Volume: 53
Issue: 3
First Page: 1146
Last Page: 1158
DOI: 10.1021/jm901414e

Standard Type	Standard Relation	Standard Value
pKa	=	5.7
pKa	=	7.6

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Beta-secretase 1

External ID: CHEMBL1273970

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2010
Volume: 20
Issue: 22
First Page: 6597
Last Page: 6605
DOI: 10.1016/j.bmcl.2010.09.029

Target ChEMBL ID: CHEMBL4822
ChEMBL Target Name: Beta-secretase 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.02	IC50	=	20	nM
0.03	IC50	=	30	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：MDCK

External ID: CHEMBL1273971

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2010
Volume: 20
Issue: 22
First Page: 6597
Last Page: 6605
DOI: 10.1016/j.bmcl.2010.09.029

Target ChEMBL ID: CHEMBL614068
ChEMBL Target Name: MDCK
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value
Ratio	=	1
Ratio	=	1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1044553

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2010
Volume: 53
Issue: 3
First Page: 1146
Last Page: 1158
DOI: 10.1021/jm901414e

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
35.1	IC50	=	35100	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Brain

External ID: CHEMBL1273972

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2010
Volume: 20
Issue: 22
First Page: 6597
Last Page: 6605
DOI: 10.1016/j.bmcl.2010.09.029

Target ChEMBL ID: CHEMBL613564
ChEMBL Target Name: Brain
ChEMBL Target Type: TISSUE - Target is a healthy or diseased tissue
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
permeability	=	81	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Renin

External ID: CHEMBL1044554

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2010
Volume: 53
Issue: 3
First Page: 1146
Last Page: 1158
DOI: 10.1021/jm901414e

Target ChEMBL ID: CHEMBL286
ChEMBL Target Name: Renin
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
13.8	IC50	=	13800	nM

26975-80-4 靶点实验数据