HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1019598

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2009
Volume: 17
Issue: 1
First Page: 149
Last Page: 164
DOI: 10.1016/j.bmc.2008.11.008

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
1.69824	Ki	=	1698.24	nM
0.15136	Ki	=	151.36	nM
0.01514	Ki	=	15.14	nM
0.0537	Ki	=	53.7	nM
0.03236	Ki	=	32.36	nM
1.90546	Ki	=	1905.46	nM
0.07943	Ki	=	79.43	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3079731

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2003
Volume: 11
Issue: 23
First Page: 5101
Last Page: 5116
DOI: 10.1016/j.bmc.2003.08.023

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
7.24436	IC50	=	7244.36	nM
0.21878	IC50	=	218.78	nM
3.89045	IC50	=	3890.45	nM
218.776	IC50	=	218776.16	nM	Outside typical range
0.0309	IC50	=	30.9	nM
0.39811	IC50	=	398.11	nM
6.76083	IC50	=	6760.83	nM
1.51356	IC50	=	1513.56	nM
0.06166	IC50	=	61.66	nM
0.12589	IC50	=	125.89	nM
0.40738	IC50	=	407.38	nM
1.28825	IC50	=	1288.25	nM
0.08913	IC50	=	89.13	nM
2.0893	IC50	=	2089.3	nM
8.71E-4	IC50	=	0.871	nM
0.01995	IC50	=	19.95	nM
1.8197	IC50	=	1819.7	nM
0.01585	IC50	=	15.85	nM
0.50119	IC50	=	501.19	nM
81.2831	IC50	=	81283.05	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Liver carboxylesterase 1

External ID: CHEMBL1019599

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2009
Volume: 17
Issue: 1
First Page: 149
Last Page: 164
DOI: 10.1016/j.bmc.2008.11.008

Target ChEMBL ID: CHEMBL2265
ChEMBL Target Name: Acyl coenzyme A:cholesterol acyltransferase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.79433	Ki	=	794.33	nM
0.12882	Ki	=	128.82	nM
0.07079	Ki	=	70.79	nM
1.90546	Ki	=	1905.46	nM
0.74131	Ki	=	741.31	nM
5.24807	Ki	=	5248.07	nM
0.79433	Ki	=	794.33	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL652796

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 1993
Volume: 3
Issue: 12
First Page: 2593
Last Page: 2598
DOI: 10.1016/S0960-894X(01)80722-8

Standard Type	Standard Units	Activity Comment
Inhibition	%	Not Determined

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Liver carboxylesterase

External ID: CHEMBL931028

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2008
Volume: 16
Issue: 4
First Page: 2114
Last Page: 2130
DOI: 10.1016/j.bmc.2007.10.081

Target ChEMBL ID: CHEMBL3383
ChEMBL Target Name: Carboxylesterase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.28	IC50	=	280	nM
0.47	IC50	=	470	nM
0.02	IC50	=	20	nM
0.012	IC50	=	12	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Liver carboxylesterase

External ID: CHEMBL931029

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2008
Volume: 16
Issue: 4
First Page: 2114
Last Page: 2130
DOI: 10.1016/j.bmc.2007.10.081

Target ChEMBL ID: CHEMBL3383
ChEMBL Target Name: Carboxylesterase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.033	IC50	=	33	nM
0.1	IC50	=	100	nM
0.0045	IC50	=	4.5	nM
0.0086	IC50	=	8.6	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Fatty-acid amide hydrolase 1

External ID: CHEMBL930039

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2008
Volume: 16
Issue: 4
First Page: 2114
Last Page: 2130
DOI: 10.1016/j.bmc.2007.10.081

Target ChEMBL ID: CHEMBL2243
ChEMBL Target Name: Anandamide amidohydrolase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
40	IC50	>	40000	nM
40	IC50	>	40000	nM
40	IC50	>	40000	nM
0.6	IC50	=	600	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Liver carboxylesterase 1

External ID: CHEMBL1019602

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2009
Volume: 17
Issue: 1
First Page: 149
Last Page: 164
DOI: 10.1016/j.bmc.2008.11.008

Target ChEMBL ID: CHEMBL2265
ChEMBL Target Name: Acyl coenzyme A:cholesterol acyltransferase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.00537	Ki	=	5.37	nM
0.003981	Ki	=	3.981	nM
0.007413	Ki	=	7.413	nM
3.981E-4	Ki	=	0.3981	nM
3.981E-4	Ki	=	0.3981	nM
5.012E-4	Ki	=	0.5012	nM
3.02E-4	Ki	=	0.302	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1019603

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2009
Volume: 17
Issue: 1
First Page: 149
Last Page: 164
DOI: 10.1016/j.bmc.2008.11.008

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.007762	Ki	=	7.762	nM
0.002818	Ki	=	2.818	nM
0.003311	Ki	=	3.311	nM
0.001413	Ki	=	1.413	nM
7.079E-4	Ki	=	0.7079	nM
0.00302	Ki	=	3.02	nM
0.001585	Ki	=	1.585	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1019600

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2009
Volume: 17
Issue: 1
First Page: 149
Last Page: 164
DOI: 10.1016/j.bmc.2008.11.008

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.41687	Ki	=	416.87	nM
0.15849	Ki	=	158.49	nM
0.15849	Ki	=	158.49	nM
1.09648	Ki	=	1096.48	nM
0.15136	Ki	=	151.36	nM
2.51189	Ki	=	2511.89	nM
0.21878	Ki	=	218.78	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1019601

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2009
Volume: 17
Issue: 1
First Page: 149
Last Page: 164
DOI: 10.1016/j.bmc.2008.11.008

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.0166	Ki	=	16.6	nM
0.004571	Ki	=	4.571	nM
0.00537	Ki	=	5.37	nM
3.981E-4	Ki	=	0.3981	nM
0.001	Ki	=	1	nM
5.012E-4	Ki	=	0.5012	nM
0.001096	Ki	=	1.096	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Fatty-acid amide hydrolase 1

External ID: CHEMBL930038

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2008
Volume: 16
Issue: 4
First Page: 2114
Last Page: 2130
DOI: 10.1016/j.bmc.2007.10.081

Target ChEMBL ID: CHEMBL2243
ChEMBL Target Name: Anandamide amidohydrolase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
40	IC50	>	40000	nM
40	IC50	>	40000	nM
40	IC50	>	40000	nM
0.44	IC50	=	440	nM

26902-72-7 靶点实验数据