HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3301371

Protocol: N/A

Comment: Data Source: AstraZeneca DMPK/physicochemical

Standard Type	Standard Relation	Standard Value	Standard Units
CL		12.02	uL.min-1.(10^6cells)-1
CL	>	150	uL.min-1.(10^6cells)-1
CL		13.18	uL.min-1.(10^6cells)-1
CL	>	150	uL.min-1.(10^6cells)-1
CL	>	150	uL.min-1.(10^6cells)-1
CL	>	150	uL.min-1.(10^6cells)-1
CL		52	uL.min-1.(10^6cells)-1
CL	>	150	uL.min-1.(10^6cells)-1
CL	<	3	uL.min-1.(10^6cells)-1
CL	>	150	uL.min-1.(10^6cells)-1
CL		144	uL.min-1.(10^6cells)-1
CL		11.75	uL.min-1.(10^6cells)-1
CL	<	3	uL.min-1.(10^6cells)-1
CL		61	uL.min-1.(10^6cells)-1
CL	>	150	uL.min-1.(10^6cells)-1
CL		24.55	uL.min-1.(10^6cells)-1
CL		14.24	uL.min-1.(10^6cells)-1
CL		13.18	uL.min-1.(10^6cells)-1
CL	<	3	uL.min-1.(10^6cells)-1
CL		114	uL.min-1.(10^6cells)-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3301370

Protocol: N/A

Comment: Data Source: AstraZeneca DMPK/physicochemical

Standard Type	Standard Relation	Standard Value	Standard Units
CL		8.33	mL.min-1.g-1
CL		4	mL.min-1.g-1
CL		13.49	mL.min-1.g-1
CL		48.98	mL.min-1.g-1
CL		5.75	mL.min-1.g-1
CL		6	mL.min-1.g-1
CL	<	3	mL.min-1.g-1
CL		43.65	mL.min-1.g-1
CL		35	mL.min-1.g-1
CL		6.31	mL.min-1.g-1
CL	<	3	mL.min-1.g-1
CL		15.14	mL.min-1.g-1
CL	<	3	mL.min-1.g-1
CL		5.75	mL.min-1.g-1
CL	<	3	mL.min-1.g-1
CL		82	mL.min-1.g-1
CL		29.51	mL.min-1.g-1
CL		6.46	mL.min-1.g-1
CL		116	mL.min-1.g-1
CL		8	mL.min-1.g-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3301372

Protocol: N/A

Comment: Data Source: AstraZeneca DMPK/physicochemical

Standard Type	Standard Relation	Standard Value	Standard Units
CL		5.37	uL.min-1.(10^6cells)-1
CL		3.46	uL.min-1.(10^6cells)-1
CL	<	3	uL.min-1.(10^6cells)-1
CL		4.17	uL.min-1.(10^6cells)-1
CL		5.62	uL.min-1.(10^6cells)-1
CL		4.9	uL.min-1.(10^6cells)-1
CL		28.18	uL.min-1.(10^6cells)-1
CL		6.17	uL.min-1.(10^6cells)-1
CL		13.18	uL.min-1.(10^6cells)-1
CL		50.12	uL.min-1.(10^6cells)-1
CL		9.33	uL.min-1.(10^6cells)-1
CL	<	3	uL.min-1.(10^6cells)-1
CL		6.76	uL.min-1.(10^6cells)-1
CL		3.89	uL.min-1.(10^6cells)-1
CL		3.72	uL.min-1.(10^6cells)-1
CL		66.07	uL.min-1.(10^6cells)-1
CL	<	3	uL.min-1.(10^6cells)-1
CL		38.9	uL.min-1.(10^6cells)-1
CL		30.2	uL.min-1.(10^6cells)-1
CL		14.45	uL.min-1.(10^6cells)-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Growth hormone secretagogue receptor type 1

External ID: CHEMBL831432

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2005
Volume: 15
Issue: 7
First Page: 1789
Last Page: 1792
DOI: 10.1016/j.bmcl.2005.02.042

Target ChEMBL ID: CHEMBL4616
ChEMBL Target Name: Ghrelin receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
2.4E-4	IC50	=	0.24	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3301363

Protocol: N/A

Comment: Data Source: AstraZeneca DMPK/physicochemical

Standard Type	Standard Value
LogD7.4	1.56
LogD7.4	1.39
LogD7.4	-0.78
LogD7.4	2.22
LogD7.4	3
LogD7.4	1.91
LogD7.4	-0.84
LogD7.4	1.19
LogD7.4	-1.08
LogD7.4	3.08
LogD7.4	3.65
LogD7.4	-0.5
LogD7.4	2.43
LogD7.4	2.3
LogD7.4	3.65
LogD7.4	4.3
LogD7.4	3.26
LogD7.4	2.55
LogD7.4	1.69
LogD7.4	1.46

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3301365

Protocol: N/A

Comment: Data Source: AstraZeneca DMPK/physicochemical

Standard Type	Standard Value	Standard Units
PPB	96	%
PPB	34.42	%
PPB	87.87	%
PPB	79.55	%
PPB	55.73	%
PPB	99.91	%
PPB	98.61	%
PPB	99.81	%
PPB	87.11	%
PPB	96.26	%
PPB	92.32	%
PPB	66.1	%
PPB	75.97	%
PPB	99.19	%
PPB	62.4	%
PPB	30.88	%
PPB	71.99	%
PPB	98.37	%
PPB	92.64	%
PPB	95.72	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：IUPHAR-DB 靶标：ghrelin receptor (Ghrelin receptor) [Homo sapiens]

External ID: 246_Human

Protocol: The International Union of Basic and Clinical Pharmacology/British Pharmacological Society (IUPHAR/BPS) Guide to PHARMACOLOGY Database (GtoPdb) uses expert subcommittees to collate peer-reviewed information from the published literature regarding individual protein targets, and describes the pharmacology, genetics, function and anatomy of each target. Its pages provide a richly curated overview of the pharmacology of receptors, ion channels, enzymes and other target types, which can be found by following the external link to the GtoPdb website.

Comment: The data collected focuses on ligands at human receptors. Data are provided at rat or mouse orthologues where there are significant species differences, or where data are not yet available at the human target.

Information on individual experimental protocols can be found in the primary references listed for each ligand.

Affinity data are expressed as pKi [-log(Ki)], pKd [-log(Kd)], pIC50 [-log(IC50)], pEC50 [-log(EC50)], pKB [-log(KB)], pA2 or as a micromolar concentration range. In most cases the original concentration can be found in the primary reference.

pKi_min	pKi_max	pKd_min	pKd_max	pIC50_min	pIC50_max	pEC50_min	pEC50_max	Type	Action	Reference (PubMed ID)
		9.4	9.4					Agonist	Full agonist	11314756
7.8	7.8							Antagonist	Antagonist	17656463
		7.3	7.3					Antagonist	Antagonist	12907757
				8.2	8.2			Antagonist	Antagonist	16854051
						7	7.6	Agonist, Allosteric modulator	Agonist, Positive	15905359
		9.4	9.4					Agonist	Full agonist	11522606
				8.3	8.3			Antagonist	Antagonist	17927165

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3301367

Protocol: N/A

Comment: Data Source: AstraZeneca DMPK/physicochemical

Standard Type	Standard Value	Standard Units
PPB	99.72	%
PPB	31.37	%
PPB	95.63	%
PPB	65.06	%
PPB	96.93	%
PPB	92.64	%
PPB	86.59	%
PPB	67.12	%
PPB	69.61	%
PPB	95.33	%
PPB	99.43	%
PPB	85.77	%
PPB	38.69	%
PPB	78.79	%
PPB	59.66	%
PPB	72.91	%
PPB	14.52	%
PPB	60.77	%
PPB	52.3	%
PPB	14.52	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3301366

Protocol: N/A

Comment: Data Source: AstraZeneca DMPK/physicochemical

Standard Type	Standard Value	Standard Units
PPB	78.41	%
PPB	43.14	%
PPB	82.72	%
PPB	87.62	%
PPB	82.05	%
PPB	99.71	%
PPB	99.3	%
PPB	34.42	%
PPB	97.95	%
PPB	93.1	%
PPB	94.79	%
PPB	93.53	%
PPB	86.85	%
PPB	98.47	%
PPB	99.85	%
PPB	98.47	%
PPB	75.12	%
PPB	99.36	%
PPB	81.36	%
PPB	83.04	%

259666-71-2 靶点实验数据