HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：BindingDB 靶标：N/A

External ID: BindingDB_2720_1

Protocol: N/A

Comment: Compounds with any of Ki, IC50, Kd, or EC50 activity value <= 10uM are labeled as "Active".
If multiple measurements are available for a given compound, it is labeled as "Active" if any of the measurements meet the criterion. Activity values are checked in the order of Ki, IC50, Kd, and EC50. The first entry that meets the above activity threshold is used to determine "Standard Type", "Standard Relation", and "PubChem Standard Value". Otherwise, the first non-empty entry will be used to set those values.

Standard Type	PubChem Standard Value	Ki	Target Accession(s)	Ligand	Target
Ki	0.45	450	P52732	BDBM23775	Kinesin-like protein KIF11
Ki	0.15	150	P52732	BDBM23802	Kinesin-like protein KIF11
Ki	0.75	750	P52732	BDBM23805	Kinesin-like protein KIF11
Ki	0.12	120	P52732	BDBM23812	Kinesin-like protein KIF11
Ki	7	7000	P52732	BDBM23813	Kinesin-like protein KIF11
Ki	0.6	600	P52732	BDBM23814	Kinesin-like protein KIF11
Ki	23	23000	P52732	BDBM23825	Kinesin-like protein KIF11

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Kinesin-like protein KIF11

External ID: CHEMBL934296

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2008
Volume: 51
Issue: 5
First Page: 1115
Last Page: 1125
DOI: 10.1021/jm070606z

Target ChEMBL ID: CHEMBL4581
ChEMBL Target Name: Kinesin-like protein 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
0.12	Ki	=	120	nM
0.2	Ki	=	200	nM
	Activity				Not Active
0.9	Ki	=	900	nM
	Activity				Not Active
1	Ki	=	1000	nM
2	Ki	=	2000	nM
0.6	Ki	=	600	nM
23	Ki	=	23000	nM
	Activity				Not Active
	Activity				Not Active
	Activity				Not Active
0.25	Ki	=	250	nM
0.2	Ki	=	200	nM
0.175	Ki	=	175	nM
0.15	Ki	=	150	nM
1.5	Ki	=	1500	nM
	Activity				Not Active
1.5	Ki	=	1500	nM
0.6	Ki	=	600	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HeLa

External ID: CHEMBL934297

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2008
Volume: 51
Issue: 5
First Page: 1115
Last Page: 1125
DOI: 10.1021/jm070606z

Target ChEMBL ID: CHEMBL399
ChEMBL Target Name: HeLa
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
0.2	EC50	=	200	nM
5	EC50	>	5000	nM
5	EC50	>	5000	nM
	EC50				Not Determined
5	EC50	>	5000	nM
5	EC50	>	5000	nM
5	EC50	>	5000	nM
	EC50				Not Determined
	EC50				Not Determined
0.31	EC50	=	310	nM
0.51	EC50	=	510	nM
1.4	EC50	=	1400	nM
1.08	EC50	=	1080	nM
5	EC50	>	5000	nM
	EC50				Not Determined
5	EC50	>	5000	nM
3.5	EC50	=	3500	nM
5	EC50	>	5000	nM

25840-83-9 靶点实验数据