HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Kinesin-like protein KIF11

External ID: CHEMBL896510

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2007
Volume: 17
Issue: 14
First Page: 3921
Last Page: 3924
DOI: 10.1016/j.bmcl.2007.04.101

Target ChEMBL ID: CHEMBL4581
ChEMBL Target Name: Kinesin-like protein 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
63	IC50	>	63000	nM
63	IC50	>	63000	nM
63	IC50	>	63000	nM
63	IC50	>	63000	nM
63	IC50	>	63000	nM
1.8	IC50	=	1800	nM
3.1	IC50	=	3100	nM
63	IC50	>	63000	nM
55	IC50	=	55000	nM
63	IC50	>	63000	nM
63	IC50	>	63000	nM
5.8	IC50	=	5800	nM
	Inhibition	=	98	%
14.8	IC50	=	14800	nM
0.22	IC50	=	220	nM
	Inhibition	=	79	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HeLa

External ID: CHEMBL896511

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2007
Volume: 17
Issue: 14
First Page: 3921
Last Page: 3924
DOI: 10.1016/j.bmcl.2007.04.101

Target ChEMBL ID: CHEMBL399
ChEMBL Target Name: HeLa
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
50	IC50	>	50000	nM
50	IC50	>	50000	nM
50	IC50	>	50000	nM
50	IC50	>	50000	nM
50	IC50	>	50000	nM
3.29	IC50	=	3290	nM
50	IC50	>	50000	nM
11.9	IC50	=	11900	nM
50	IC50	>	50000	nM
16.5	IC50	=	16500	nM
1.72	IC50	=	1720	nM
49.7	IC50	=	49700	nM
0.53	IC50	=	530	nM
0.32	IC50	=	320	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Kynurenine--oxoglutarate transaminase 1

External ID: CHEMBL656041

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1996
Volume: 39
Issue: 10
First Page: 2040
Last Page: 2046
DOI: 10.1021/jm950750x

Target ChEMBL ID: CHEMBL3962
ChEMBL Target Name: Kynurenine--oxoglutarate transaminase I
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Specific activity	=	4	nM min-1 mg-1
Specific activity	=	0.2	nM min-1 mg-1
Specific activity	=	13.8	nM min-1 mg-1
Specific activity	=	0.1	nM min-1 mg-1
Specific activity	=	0.3	nM min-1 mg-1
Specific activity	=	10.2	nM min-1 mg-1
Specific activity	=	0.2	nM min-1 mg-1
Specific activity	=	3.3	nM min-1 mg-1
Specific activity	=	4.9	nM min-1 mg-1
Specific activity	=	9.8	nM min-1 mg-1

2544-31-2 靶点实验数据