HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Kinesin-like protein KIF11

External ID: CHEMBL1177081

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2010
Volume: 53
Issue: 13
First Page: 5054
Last Page: 5058
DOI: 10.1021/jm100476d

Target ChEMBL ID: CHEMBL4581
ChEMBL Target Name: Kinesin-like protein 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	10	%
Inhibition	=	3	%
Inhibition	<	50	%
Inhibition	<	50	%
Inhibition	<	50	%
Inhibition	<	50	%
Inhibition	=	51	%
Inhibition	=	3	%
Inhibition	=	1	%
Inhibition	=	100	%
Inhibition	=	100	%
Inhibition	=	28	%
Inhibition	=	31	%
Inhibition	=	15	%
Inhibition	=	93	%
Inhibition	=	1	%
Inhibition	=	15	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Nucleic Acid

External ID: CHEMBL1177093

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2010
Volume: 53
Issue: 13
First Page: 5054
Last Page: 5058
DOI: 10.1021/jm100476d

Target ChEMBL ID: CHEMBL345
ChEMBL Target Name: Nucleic Acid
ChEMBL Target Type: NUCLEIC-ACID - Target is DNA, RNA or PNA
Relationship Type: M - Molecular target other than protein assigned
Confidence: Target assigned is molecular non-protein target

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HeLa

External ID: CHEMBL1177091

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2010
Volume: 53
Issue: 13
First Page: 5054
Last Page: 5058
DOI: 10.1021/jm100476d

Target ChEMBL ID: CHEMBL399
ChEMBL Target Name: HeLa
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	76	%
Activity	=	37	%
Inhibition	=	70	%
Activity	=	57	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1177088

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2010
Volume: 53
Issue: 13
First Page: 5054
Last Page: 5058
DOI: 10.1021/jm100476d

Standard Type	Standard Units	Activity Comment
Inhibition	%	Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1177087

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2010
Volume: 53
Issue: 13
First Page: 5054
Last Page: 5058
DOI: 10.1021/jm100476d

Standard Type	Standard Units	Activity Comment
Inhibition	%	Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Kinesin-like protein KIF23

External ID: CHEMBL1177086

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2010
Volume: 53
Issue: 13
First Page: 5054
Last Page: 5058
DOI: 10.1021/jm100476d

Target ChEMBL ID: CHEMBL5899
ChEMBL Target Name: Kinesin-like protein KIF23
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Units	Activity Comment
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Kinesin-like protein KIF22

External ID: CHEMBL1177085

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2010
Volume: 53
Issue: 13
First Page: 5054
Last Page: 5058
DOI: 10.1021/jm100476d

Target ChEMBL ID: CHEMBL5470
ChEMBL Target Name: Kinesin-like protein KIF22
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Units	Activity Comment
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Chromosome-associated kinesin KIF4A

External ID: CHEMBL1177084

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2010
Volume: 53
Issue: 13
First Page: 5054
Last Page: 5058
DOI: 10.1021/jm100476d

Target ChEMBL ID: CHEMBL6163
ChEMBL Target Name: Chromosome-associated kinesin KIF4A
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Units	Activity Comment
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Centromere-associated protein E

External ID: CHEMBL1177083

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2010
Volume: 53
Issue: 13
First Page: 5054
Last Page: 5058
DOI: 10.1021/jm100476d

Target ChEMBL ID: CHEMBL5870
ChEMBL Target Name: Centromere-associated protein E
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Units	Activity Comment
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Kinesin-like protein KIF11

External ID: CHEMBL1177082

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2010
Volume: 53
Issue: 13
First Page: 5054
Last Page: 5058
DOI: 10.1021/jm100476d

Target ChEMBL ID: CHEMBL4581
ChEMBL Target Name: Kinesin-like protein 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
3.3	IC50	=	3300	nM
14	IC50	=	14000	nM
13	IC50	=	13000	nM
2.8	IC50	=	2800	nM
1.5	IC50	=	1500	nM
0.87	IC50	=	870	nM
0.51	IC50	=	510	nM
1.6	IC50	=	1600	nM
0.26	IC50	=	260	nM
0.95	IC50	=	950	nM
7.5	IC50	=	7500	nM
11	IC50	=	11000	nM
1.6	IC50	=	1600	nM

2467-83-6 靶点实验数据