HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5041680

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 3.0
First Page: 2107
Last Page: 2121
DOI: 10.1021/acs.jmedchem.1c01637

Standard Type	Standard Relation	Standard Value	Standard Units
MRT	=	8.59	hr
MRT	=	9.43	hr

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5041684

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 3.0
First Page: 2107
Last Page: 2121
DOI: 10.1021/acs.jmedchem.1c01637

Standard Type	Standard Relation	Standard Value	Standard Units
AUC	=	848	ng.hr.mL-1
AUC	=	639	ng.hr.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5041683

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 3.0
First Page: 2107
Last Page: 2121
DOI: 10.1021/acs.jmedchem.1c01637

Standard Type	Standard Relation	Standard Value
Ratio CC50/EC50	>	2445
Ratio	>	3278
Ratio CC50/EC50	>	81
Ratio	>	114
Ratio CC50/EC50	=	364
Ratio CC50/EC50	=	1931
Ratio CC50/EC50	=	823
Ratio CC50/EC50	=	1128
Ratio CC50/EC50	=	549

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Hepacivirus hominis

External ID: CHEMBL5041682

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 3.0
First Page: 2107
Last Page: 2121
DOI: 10.1021/acs.jmedchem.1c01637

Target ChEMBL ID: CHEMBL379
ChEMBL Target Name: Hepatitis C virus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.175	EC50	=	175	nM
1.03	EC50	=	1030	nM
0.956	EC50	=	956	nM
0.007	EC50	=	7	nM
0.045	EC50	=	45	nM
1.519	EC50	=	1519	nM
0.22	EC50	=	220	nM
4	EC50	>	4000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Huh-7.5

External ID: CHEMBL5041681

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 3.0
First Page: 2107
Last Page: 2121
DOI: 10.1021/acs.jmedchem.1c01637

Target ChEMBL ID: CHEMBL5058629
ChEMBL Target Name: Huh-7.5
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
21.21	CC50	=	21210	nM
44.14	CC50	=	44140	nM
31.28	CC50	=	31280	nM
1.45	CC50	=	1450	nM
20	CC50	>	20000	nM
2.97	CC50	=	2970	nM
5.38	CC50	=	5380	nM
13.78	CC50	=	13780	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Hepacivirus hominis

External ID: CHEMBL5041704

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 3.0
First Page: 2107
Last Page: 2121
DOI: 10.1021/acs.jmedchem.1c01637

Target ChEMBL ID: CHEMBL379
ChEMBL Target Name: Hepatitis C virus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Active
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Hepacivirus hominis

External ID: CHEMBL5041703

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 3.0
First Page: 2107
Last Page: 2121
DOI: 10.1021/acs.jmedchem.1c01637

Target ChEMBL ID: CHEMBL379
ChEMBL Target Name: Hepatitis C virus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active
Activity	Active
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5041702

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 3.0
First Page: 2107
Last Page: 2121
DOI: 10.1021/acs.jmedchem.1c01637

Standard Type	Standard Relation	Standard Value
Ratio CC50/EC50	=	1328
Ratio CC50/EC50	=	72
Ratio CC50/EC50	=	118
Ratio CC50/EC50	=	1144

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Hepacivirus hominis

External ID: CHEMBL5041701

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 3.0
First Page: 2107
Last Page: 2121
DOI: 10.1021/acs.jmedchem.1c01637

Target ChEMBL ID: CHEMBL379
ChEMBL Target Name: Hepatitis C virus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Hepacivirus hominis

External ID: CHEMBL5041696

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 3.0
First Page: 2107
Last Page: 2121
DOI: 10.1021/acs.jmedchem.1c01637

Target ChEMBL ID: CHEMBL379
ChEMBL Target Name: Hepatitis C virus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Histamine H1 receptor

External ID: CHEMBL5041695

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 3.0
First Page: 2107
Last Page: 2121
DOI: 10.1021/acs.jmedchem.1c01637

Target ChEMBL ID: CHEMBL231
ChEMBL Target Name: Histamine H1 receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Activity				Not Active
Activity				Not Active
Activity				Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5041693

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 3.0
First Page: 2107
Last Page: 2121
DOI: 10.1021/acs.jmedchem.1c01637

Standard Type	Activity Comment
Activity	Not Active
Activity	Active
Activity	Active
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Hepacivirus hominis

External ID: CHEMBL5041700

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 3.0
First Page: 2107
Last Page: 2121
DOI: 10.1021/acs.jmedchem.1c01637

Target ChEMBL ID: CHEMBL379
ChEMBL Target Name: Hepatitis C virus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Active
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Hepacivirus hominis

External ID: CHEMBL5041699

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 3.0
First Page: 2107
Last Page: 2121
DOI: 10.1021/acs.jmedchem.1c01637

Target ChEMBL ID: CHEMBL379
ChEMBL Target Name: Hepatitis C virus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Hepacivirus hominis

External ID: CHEMBL5041698

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 3.0
First Page: 2107
Last Page: 2121
DOI: 10.1021/acs.jmedchem.1c01637

Target ChEMBL ID: CHEMBL379
ChEMBL Target Name: Hepatitis C virus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Active
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Hepacivirus hominis

External ID: CHEMBL5041697

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 3.0
First Page: 2107
Last Page: 2121
DOI: 10.1021/acs.jmedchem.1c01637

Target ChEMBL ID: CHEMBL379
ChEMBL Target Name: Hepatitis C virus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5041692

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 3.0
First Page: 2107
Last Page: 2121
DOI: 10.1021/acs.jmedchem.1c01637

Standard Type	Standard Relation	Standard Value	Standard Units
Cp	=	6.06	ng/ml
Cp	=	4.98	ng/ml

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5041690

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 3.0
First Page: 2107
Last Page: 2121
DOI: 10.1021/acs.jmedchem.1c01637

Standard Type	Standard Relation	Standard Value	Standard Units
Tmax	=	5.33	hr
Tmax	=	2.69	hr

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5041689

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 3.0
First Page: 2107
Last Page: 2121
DOI: 10.1021/acs.jmedchem.1c01637

Standard Type	Standard Relation	Standard Value	Standard Units
T1/2	=	4.87	hr
T1/2	=	5.66	hr

2425804-98-2 靶点实验数据