HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Peroxisome proliferator-activated receptor gamma

External ID: CHEMBL4276397

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2018
Volume: 61
Issue: 22
First Page: 10067
Last Page: 10083
DOI: 10.1021/acs.jmedchem.8b01200

Target ChEMBL ID: CHEMBL235
ChEMBL Target Name: Peroxisome proliferator-activated receptor gamma
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Efficacy	=	100	%
Efficacy	=	8.3	%
Efficacy	=	11	%
Efficacy	=	11	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Peroxisome proliferator-activated receptor gamma

External ID: CHEMBL4276396

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2018
Volume: 61
Issue: 22
First Page: 10067
Last Page: 10083
DOI: 10.1021/acs.jmedchem.8b01200

Target ChEMBL ID: CHEMBL235
ChEMBL Target Name: Peroxisome proliferator-activated receptor gamma
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.163	EC50	=	163	nM
0.017	EC50	=	17	nM
0.0024	EC50	=	2.4	nM
0.166	EC50	=	166	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Peroxisome proliferator-activated receptor gamma

External ID: CHEMBL3587210

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2015
Volume: 58
Issue: 14
First Page: 5381
Last Page: 5394
DOI: 10.1021/jm501155f

Target ChEMBL ID: CHEMBL235
ChEMBL Target Name: Peroxisome proliferator-activated receptor gamma
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
%max	=	25	%
%max	=	39	%
%max	=	80	%
%max	=	100	%
%max	=	10	%

24136-23-0 靶点实验数据