HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5510224

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2024
Volume: 67
Issue: 10
First Page: 7836
Last Page: 7858
DOI: 10.1021/acs.jmedchem.4c00027

Standard Type	Standard Relation	Standard Value	Standard Units
CL	=	48.7	mL.min-1.g-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5510223

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2024
Volume: 67
Issue: 10
First Page: 7836
Last Page: 7858
DOI: 10.1021/acs.jmedchem.4c00027

Standard Type	Standard Relation	Standard Value	Standard Units
CL	=	32.8	mL.min-1.g-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5510222

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2024
Volume: 67
Issue: 10
First Page: 7836
Last Page: 7858
DOI: 10.1021/acs.jmedchem.4c00027

Standard Type	Standard Relation	Standard Value	Standard Units
CL	=	28.9	mL.min-1.g-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5510221

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2024
Volume: 67
Issue: 10
First Page: 7836
Last Page: 7858
DOI: 10.1021/acs.jmedchem.4c00027

Standard Type	Standard Relation	Standard Value	Standard Units
CL	=	30.3	mL.min-1.g-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cytochrome P450 3A4

External ID: CHEMBL5510220

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2024
Volume: 67
Issue: 10
First Page: 7836
Last Page: 7858
DOI: 10.1021/acs.jmedchem.4c00027

Target ChEMBL ID: CHEMBL340
ChEMBL Target Name: Cytochrome P450 3A4
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
10	IC50	>	10000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cytochrome P450 2D6

External ID: CHEMBL5510219

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2024
Volume: 67
Issue: 10
First Page: 7836
Last Page: 7858
DOI: 10.1021/acs.jmedchem.4c00027

Target ChEMBL ID: CHEMBL289
ChEMBL Target Name: Cytochrome P450 2D6
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
10	IC50	>	10000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cytochrome P450 2C19

External ID: CHEMBL5510218

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2024
Volume: 67
Issue: 10
First Page: 7836
Last Page: 7858
DOI: 10.1021/acs.jmedchem.4c00027

Target ChEMBL ID: CHEMBL3622
ChEMBL Target Name: Cytochrome P450 2C19
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
10	IC50	>	10000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cytochrome P450 2C9

External ID: CHEMBL5510217

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2024
Volume: 67
Issue: 10
First Page: 7836
Last Page: 7858
DOI: 10.1021/acs.jmedchem.4c00027

Target ChEMBL ID: CHEMBL3397
ChEMBL Target Name: Cytochrome P450 2C9
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
10	IC50	>	10000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cytochrome P450 1A2

External ID: CHEMBL5510216

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2024
Volume: 67
Issue: 10
First Page: 7836
Last Page: 7858
DOI: 10.1021/acs.jmedchem.4c00027

Target ChEMBL ID: CHEMBL3356
ChEMBL Target Name: Cytochrome P450 1A2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
10	IC50	>	10000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Apoptosis regulator Bcl-2

External ID: CHEMBL5510215

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2024
Volume: 67
Issue: 10
First Page: 7836
Last Page: 7858
DOI: 10.1021/acs.jmedchem.4c00027

Target ChEMBL ID: CHEMBL4860
ChEMBL Target Name: Apoptosis regulator Bcl-2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
3.4E-4	IC50	=	0.34	nM
0.0025	IC50	=	2.5	nM
0.017	IC50	=	17	nM
0.0037	IC50	=	3.7	nM
0.0032	IC50	=	3.2	nM
0.0031	IC50	=	3.1	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：MOLT-4

External ID: CHEMBL5510214

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2024
Volume: 67
Issue: 10
First Page: 7836
Last Page: 7858
DOI: 10.1021/acs.jmedchem.4c00027

Target ChEMBL ID: CHEMBL614177
ChEMBL Target Name: MOLT-4
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
5.194	IC50	=	5194	nM
	IC50				Not Determined
10	IC50	>	10000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：RS4-11

External ID: CHEMBL5510213

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2024
Volume: 67
Issue: 10
First Page: 7836
Last Page: 7858
DOI: 10.1021/acs.jmedchem.4c00027

Target ChEMBL ID: CHEMBL2366159
ChEMBL Target Name: RS4-11
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
5.6E-4	IC50	=	0.56	nM
0.0026	IC50	=	2.6	nM
0.565	IC50	=	565	nM
	IC50				Not Determined
0.05	IC50	=	50	nM
7.0E-4	IC50	=	0.7	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Bcl-2-like protein 1

External ID: CHEMBL5510212

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2024
Volume: 67
Issue: 10
First Page: 7836
Last Page: 7858
DOI: 10.1021/acs.jmedchem.4c00027

Target ChEMBL ID: CHEMBL4625
ChEMBL Target Name: Bcl-2-like protein 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.423	IC50	=	423	nM
0.9	IC50	=	900	nM
0.926	IC50	=	926	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Apoptosis regulator Bcl-2

External ID: CHEMBL5510211

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2024
Volume: 67
Issue: 10
First Page: 7836
Last Page: 7858
DOI: 10.1021/acs.jmedchem.4c00027

Target ChEMBL ID: CHEMBL4860
ChEMBL Target Name: Apoptosis regulator Bcl-2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
1.9E-5	IC50	=	0.019	nM
2.4E-5	IC50	=	0.024	nM
0.023	IC50	=	23	nM
0.0089	IC50	=	8.9	nM
0.003	IC50	=	3	nM
3.8E-5	IC50	=	0.038	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：RS4-11

External ID: CHEMBL5510250

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2024
Volume: 67
Issue: 10
First Page: 7836
Last Page: 7858
DOI: 10.1021/acs.jmedchem.4c00027

Target ChEMBL ID: CHEMBL2366159
ChEMBL Target Name: RS4-11
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
TGI	=	103	%
TGI	=	104	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：RS4-11

External ID: CHEMBL5510249

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2024
Volume: 67
Issue: 10
First Page: 7836
Last Page: 7858
DOI: 10.1021/acs.jmedchem.4c00027

Target ChEMBL ID: CHEMBL2366159
ChEMBL Target Name: RS4-11
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
TGI	=	86	%
TGI	=	103	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：RS4-11

External ID: CHEMBL5510248

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2024
Volume: 67
Issue: 10
First Page: 7836
Last Page: 7858
DOI: 10.1021/acs.jmedchem.4c00027

Target ChEMBL ID: CHEMBL2366159
ChEMBL Target Name: RS4-11
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：RS4-11

External ID: CHEMBL5510247

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2024
Volume: 67
Issue: 10
First Page: 7836
Last Page: 7858
DOI: 10.1021/acs.jmedchem.4c00027

Target ChEMBL ID: CHEMBL2366159
ChEMBL Target Name: RS4-11
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Active
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5510246

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2024
Volume: 67
Issue: 10
First Page: 7836
Last Page: 7858
DOI: 10.1021/acs.jmedchem.4c00027

Standard Type	Activity Comment
Activity	Non-Toxic

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：RS4-11

External ID: CHEMBL5510245

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2024
Volume: 67
Issue: 10
First Page: 7836
Last Page: 7858
DOI: 10.1021/acs.jmedchem.4c00027

Target ChEMBL ID: CHEMBL2366159
ChEMBL Target Name: RS4-11
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5510244

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2024
Volume: 67
Issue: 10
First Page: 7836
Last Page: 7858
DOI: 10.1021/acs.jmedchem.4c00027

Standard Type	Standard Relation	Standard Value	Standard Units
F	=	54.9	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5510243

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2024
Volume: 67
Issue: 10
First Page: 7836
Last Page: 7858
DOI: 10.1021/acs.jmedchem.4c00027

Standard Type	Standard Relation	Standard Value	Standard Units
AUC	=	16188	ng.hr.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5510242

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2024
Volume: 67
Issue: 10
First Page: 7836
Last Page: 7858
DOI: 10.1021/acs.jmedchem.4c00027

Standard Type	Standard Relation	Standard Value	Standard Units
T1/2	=	3.56	hr

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5510241

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2024
Volume: 67
Issue: 10
First Page: 7836
Last Page: 7858
DOI: 10.1021/acs.jmedchem.4c00027

Standard Type	Standard Relation	Standard Value	Standard Units
Tmax	=	3.33	hr

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5510239

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2024
Volume: 67
Issue: 10
First Page: 7836
Last Page: 7858
DOI: 10.1021/acs.jmedchem.4c00027

Standard Type	Standard Relation	Standard Value	Standard Units
F	=	20.3	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5510238

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2024
Volume: 67
Issue: 10
First Page: 7836
Last Page: 7858
DOI: 10.1021/acs.jmedchem.4c00027

Standard Type	Standard Relation	Standard Value	Standard Units
AUC	=	1248	ng.hr.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5510236

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2024
Volume: 67
Issue: 10
First Page: 7836
Last Page: 7858
DOI: 10.1021/acs.jmedchem.4c00027

Standard Type	Standard Relation	Standard Value	Standard Units
Tmax	=	4	hr

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5510234

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2024
Volume: 67
Issue: 10
First Page: 7836
Last Page: 7858
DOI: 10.1021/acs.jmedchem.4c00027

Standard Type	Standard Relation	Standard Value	Standard Units
Vdss	=	0.46	L.kg-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5510233

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2024
Volume: 67
Issue: 10
First Page: 7836
Last Page: 7858
DOI: 10.1021/acs.jmedchem.4c00027

Standard Type	Standard Relation	Standard Value	Standard Units
CL	=	0.00296	mL.min-1.kg-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5510232

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2024
Volume: 67
Issue: 10
First Page: 7836
Last Page: 7858
DOI: 10.1021/acs.jmedchem.4c00027

Standard Type	Standard Relation	Standard Value	Standard Units
AUC	=	5893	ng.hr.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：BindingDB 靶标：N/A

External ID: BindingDB_10777_3

Protocol: N/A

Comment: Compounds with any of Ki, IC50, Kd, or EC50 activity value <= 10uM are labeled as "Active".
If multiple measurements are available for a given compound, it is labeled as "Active" if any of the measurements meet the criterion. Activity values are checked in the order of Ki, IC50, Kd, and EC50. The first entry that meets the above activity threshold is used to determine "Standard Type", "Standard Relation", and "PubChem Standard Value". Otherwise, the first non-empty entry will be used to set those values.

Standard Type	PubChem Standard Value	IC50	Target Accession(s)	Ligand	Target
IC50	0.049	49	P10415	BDBM567259	Apoptosis regulator Bcl-2
IC50	0.083	83	P10415	BDBM567260	Apoptosis regulator Bcl-2
IC50	0.0021	2.1	P10415	BDBM567682	Apoptosis regulator Bcl-2
IC50	0.0013	1.3	P10415	BDBM567721	Apoptosis regulator Bcl-2

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5510231

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2024
Volume: 67
Issue: 10
First Page: 7836
Last Page: 7858
DOI: 10.1021/acs.jmedchem.4c00027

Standard Type	Standard Relation	Standard Value	Standard Units
T1/2	=	3.32	hr

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：BindingDB 靶标：N/A

External ID: BindingDB_10777_2

Protocol: N/A

Comment: Compounds with any of Ki, IC50, Kd, or EC50 activity value <= 10uM are labeled as "Active".
If multiple measurements are available for a given compound, it is labeled as "Active" if any of the measurements meet the criterion. Activity values are checked in the order of Ki, IC50, Kd, and EC50. The first entry that meets the above activity threshold is used to determine "Standard Type", "Standard Relation", and "PubChem Standard Value". Otherwise, the first non-empty entry will be used to set those values.

Standard Type	PubChem Standard Value	IC50	Target Accession(s)	Ligand	Target
IC50	0.04	40	P10415	BDBM567232	Apoptosis regulator Bcl-2
IC50	0.1	100	P10415	BDBM567269	Apoptosis regulator Bcl-2
IC50	4.5E-5	0.045	P10415	BDBM567421	Apoptosis regulator Bcl-2
IC50	0.043	43	Q07817	BDBM567664	Bcl-2-like protein 1
IC50	0.0012	1.2	P10415	BDBM567665	Apoptosis regulator Bcl-2
IC50	3.402	3402	Q07817	BDBM567665	Bcl-2-like protein 1
IC50	9.8E-4	0.98	P10415	BDBM567666	Apoptosis regulator Bcl-2
IC50	0.132	132	Q07817	BDBM567682	Bcl-2-like protein 1
IC50	7.4E-4	0.74	P10415	BDBM567683	Apoptosis regulator Bcl-2
IC50	2.907	2907	Q07817	BDBM567683	Bcl-2-like protein 1
IC50	0.0021	2.1	P10415	BDBM567684	Apoptosis regulator Bcl-2
IC50	0.028	28	Q07817	BDBM567801	Bcl-2-like protein 1
IC50	2.0E-5	0.02	P10415	BDBM567801	Apoptosis regulator Bcl-2

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5510230

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2024
Volume: 67
Issue: 10
First Page: 7836
Last Page: 7858
DOI: 10.1021/acs.jmedchem.4c00027

Standard Type	Standard Relation	Standard Value	Standard Units
Vdss	=	1.72	L.kg-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5510229

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2024
Volume: 67
Issue: 10
First Page: 7836
Last Page: 7858
DOI: 10.1021/acs.jmedchem.4c00027

Standard Type	Standard Relation	Standard Value	Standard Units
CL	=	0.0262	mL.min-1.kg-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5510228

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2024
Volume: 67
Issue: 10
First Page: 7836
Last Page: 7858
DOI: 10.1021/acs.jmedchem.4c00027

Standard Type	Standard Relation	Standard Value	Standard Units
AUC	=	628	ng.hr.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5510227

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2024
Volume: 67
Issue: 10
First Page: 7836
Last Page: 7858
DOI: 10.1021/acs.jmedchem.4c00027

Standard Type	Standard Relation	Standard Value	Standard Units
T1/2	=	1.68	hr

2383086-06-2 靶点实验数据