HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cytochrome P450 2A6

External ID: CHEMBL3390302

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2014
Volume: 22
Issue: 23
First Page: 6655
Last Page: 6664
DOI: 10.1016/j.bmc.2014.10.001

Target ChEMBL ID: CHEMBL5282
ChEMBL Target Name: Cytochrome P450 2A6
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
11	IC50	=	11000	nM
0.01	Ki	=	10	nM
0.1	IC50	=	100	nM
8.1	IC50	=	8100	nM
17	IC50	=	17000	nM
0.07	Ki	=	70	nM
0.3	IC50	=	300	nM
0.06	Ki	=	60	nM
0.4	IC50	=	400	nM
0.09	Ki	=	90	nM
0.4	IC50	=	400	nM
0.5	IC50	=	500	nM
0.2	Ki	=	200	nM
0.7	IC50	=	700	nM
0.9	IC50	=	900	nM
1.4	IC50	=	1400	nM
1.5	IC50	=	1500	nM
0.8	Ki	=	800	nM
2.2	IC50	=	2200	nM
3.2	IC50	=	3200	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cytochrome P450 2A6

External ID: CHEMBL3390303

Protocol: N/A

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
	Inhibition				Active
	Inhibition				Active
	Inhibition				Active
	Inhibition				Active
	Inhibition				Active
	Inhibition				Active
	Inhibition				Active
	Inhibition				Active
	Inhibition				Active
	Inhibition				Active
0.8	IC50	=	800	nM
	Inhibition				Active
0.5	IC50	=	500	nM
	Inhibition				Active
	Inhibition				Active
0.4	IC50	=	400	nM
	Inhibition				Active
	Inhibition				Active
	Inhibition				Active
	Inhibition				Active

23799-60-2 靶点实验数据