HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Serine/threonine-protein kinase PAK 2

External ID: CHEMBL3794943

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2016
Volume: 26
Issue: 9
First Page: 2370
Last Page: 2374
DOI: 10.1016/j.bmcl.2016.03.006

Target ChEMBL ID: CHEMBL4487
ChEMBL Target Name: Serine/threonine-protein kinase PAK 2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	0.8	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Ribosomal protein S6 kinase beta-1

External ID: CHEMBL3794942

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2016
Volume: 26
Issue: 9
First Page: 2370
Last Page: 2374
DOI: 10.1016/j.bmcl.2016.03.006

Target ChEMBL ID: CHEMBL4501
ChEMBL Target Name: Ribosomal protein S6 kinase 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	47.3	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mitogen-activated protein kinase 14

External ID: CHEMBL3794941

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2016
Volume: 26
Issue: 9
First Page: 2370
Last Page: 2374
DOI: 10.1016/j.bmcl.2016.03.006

Target ChEMBL ID: CHEMBL260
ChEMBL Target Name: MAP kinase p38 alpha
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	6.9	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Serine/threonine-protein kinase Nek2

External ID: CHEMBL3794940

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2016
Volume: 26
Issue: 9
First Page: 2370
Last Page: 2374
DOI: 10.1016/j.bmcl.2016.03.006

Target ChEMBL ID: CHEMBL3835
ChEMBL Target Name: Serine/threonine-protein kinase NEK2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	2.3	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：cAMP-dependent protein kinase catalytic subunit alpha

External ID: CHEMBL3794947

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2016
Volume: 26
Issue: 9
First Page: 2370
Last Page: 2374
DOI: 10.1016/j.bmcl.2016.03.006

Target ChEMBL ID: CHEMBL4101
ChEMBL Target Name: cAMP-dependent protein kinase alpha-catalytic subunit
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	3.1	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Serine/threonine-protein kinase pim-1

External ID: CHEMBL3794946

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2016
Volume: 26
Issue: 9
First Page: 2370
Last Page: 2374
DOI: 10.1016/j.bmcl.2016.03.006

Target ChEMBL ID: CHEMBL2147
ChEMBL Target Name: Serine/threonine-protein kinase PIM1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	3.1	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial

External ID: CHEMBL3794945

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2016
Volume: 26
Issue: 9
First Page: 2370
Last Page: 2374
DOI: 10.1016/j.bmcl.2016.03.006

Target ChEMBL ID: CHEMBL4766
ChEMBL Target Name: Pyruvate dehydrogenase kinase isoform 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	-2.1	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Lymphokine-activated killer T-cell-originated protein kinase

External ID: CHEMBL3794944

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2016
Volume: 26
Issue: 9
First Page: 2370
Last Page: 2374
DOI: 10.1016/j.bmcl.2016.03.006

Target ChEMBL ID: CHEMBL4896
ChEMBL Target Name: PDZ-binding kinase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	4.5	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Serine/threonine-protein kinase Sgk1

External ID: CHEMBL3794951

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2016
Volume: 26
Issue: 9
First Page: 2370
Last Page: 2374
DOI: 10.1016/j.bmcl.2016.03.006

Target ChEMBL ID: CHEMBL2343
ChEMBL Target Name: Serine/threonine-protein kinase Sgk1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	42.4	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rho-associated protein kinase 1

External ID: CHEMBL3794950

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2016
Volume: 26
Issue: 9
First Page: 2370
Last Page: 2374
DOI: 10.1016/j.bmcl.2016.03.006

Target ChEMBL ID: CHEMBL3231
ChEMBL Target Name: Rho-associated protein kinase 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	3.3	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Serine/threonine-protein kinase D2

External ID: CHEMBL3794949

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2016
Volume: 26
Issue: 9
First Page: 2370
Last Page: 2374
DOI: 10.1016/j.bmcl.2016.03.006

Target ChEMBL ID: CHEMBL4900
ChEMBL Target Name: Serine/threonine-protein kinase D2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	1.3	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Protein kinase C alpha type

External ID: CHEMBL3794948

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2016
Volume: 26
Issue: 9
First Page: 2370
Last Page: 2374
DOI: 10.1016/j.bmcl.2016.03.006

Target ChEMBL ID: CHEMBL299
ChEMBL Target Name: Protein kinase C alpha
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	2.4	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Serine/threonine-protein kinase Chk1

External ID: CHEMBL3794927

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2016
Volume: 26
Issue: 9
First Page: 2370
Last Page: 2374
DOI: 10.1016/j.bmcl.2016.03.006

Target ChEMBL ID: CHEMBL4630
ChEMBL Target Name: Serine/threonine-protein kinase Chk1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	10.9	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cyclin-A2

External ID: CHEMBL3794926

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2016
Volume: 26
Issue: 9
First Page: 2370
Last Page: 2374
DOI: 10.1016/j.bmcl.2016.03.006

Target ChEMBL ID: CHEMBL3038469
ChEMBL Target Name: CDK2/Cyclin A2
ChEMBL Target Type: PROTEIN COMPLEX - Target is a defined protein complex, consisting of multiple subunits
Relationship Type: D - Direct protein target assigned
Confidence: Direct protein complex subunits assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	86.3	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Calcium/calmodulin-dependent protein kinase type IV

External ID: CHEMBL3794925

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2016
Volume: 26
Issue: 9
First Page: 2370
Last Page: 2374
DOI: 10.1016/j.bmcl.2016.03.006

Target ChEMBL ID: CHEMBL2494
ChEMBL Target Name: CaM kinase IV
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	21.2	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Testis-specific serine/threonine-protein kinase 1

External ID: CHEMBL3794924

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2016
Volume: 26
Issue: 9
First Page: 2370
Last Page: 2374
DOI: 10.1016/j.bmcl.2016.03.006

Target ChEMBL ID: CHEMBL6003
ChEMBL Target Name: Testis-specific serine/threonine-protein kinase 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	12.9	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mitogen-activated protein kinase 1

External ID: CHEMBL3794931

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2016
Volume: 26
Issue: 9
First Page: 2370
Last Page: 2374
DOI: 10.1016/j.bmcl.2016.03.006

Target ChEMBL ID: CHEMBL4040
ChEMBL Target Name: MAP kinase ERK2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	7	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Dual specificity tyrosine-phosphorylation-regulated kinase 1B

External ID: CHEMBL3794930

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2016
Volume: 26
Issue: 9
First Page: 2370
Last Page: 2374
DOI: 10.1016/j.bmcl.2016.03.006

Target ChEMBL ID: CHEMBL5543
ChEMBL Target Name: Dual specificity tyrosine-phosphorylation-regulated kinase 1B
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	53.6	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Death-associated protein kinase 1

External ID: CHEMBL3794929

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2016
Volume: 26
Issue: 9
First Page: 2370
Last Page: 2374
DOI: 10.1016/j.bmcl.2016.03.006

Target ChEMBL ID: CHEMBL2558
ChEMBL Target Name: Death-associated protein kinase 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	32.9	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Casein kinase I isoform epsilon

External ID: CHEMBL3794928

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2016
Volume: 26
Issue: 9
First Page: 2370
Last Page: 2374
DOI: 10.1016/j.bmcl.2016.03.006

Target ChEMBL ID: CHEMBL4937
ChEMBL Target Name: Casein kinase I epsilon
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	51.3	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Interleukin-1 receptor-associated kinase 4

External ID: CHEMBL3794935

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2016
Volume: 26
Issue: 9
First Page: 2370
Last Page: 2374
DOI: 10.1016/j.bmcl.2016.03.006

Target ChEMBL ID: CHEMBL3778
ChEMBL Target Name: Interleukin-1 receptor-associated kinase 4
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	19.7	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Inhibitor of nuclear factor kappa-B kinase subunit beta

External ID: CHEMBL3794934

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2016
Volume: 26
Issue: 9
First Page: 2370
Last Page: 2374
DOI: 10.1016/j.bmcl.2016.03.006

Target ChEMBL ID: CHEMBL1991
ChEMBL Target Name: Inhibitor of nuclear factor kappa B kinase beta subunit
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	0.7	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mitogen-activated protein kinase kinase kinase kinase 4

External ID: CHEMBL3794933

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2016
Volume: 26
Issue: 9
First Page: 2370
Last Page: 2374
DOI: 10.1016/j.bmcl.2016.03.006

Target ChEMBL ID: CHEMBL6166
ChEMBL Target Name: Mitogen-activated protein kinase kinase kinase kinase 4
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	92.5	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Glycogen synthase kinase-3 beta

External ID: CHEMBL3794932

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2016
Volume: 26
Issue: 9
First Page: 2370
Last Page: 2374
DOI: 10.1016/j.bmcl.2016.03.006

Target ChEMBL ID: CHEMBL262
ChEMBL Target Name: Glycogen synthase kinase-3 beta
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	51	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Serine/threonine-protein kinase 4

External ID: CHEMBL3794938

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2016
Volume: 26
Issue: 9
First Page: 2370
Last Page: 2374
DOI: 10.1016/j.bmcl.2016.03.006

Target ChEMBL ID: CHEMBL4598
ChEMBL Target Name: Serine/threonine-protein kinase MST1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	31.9	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：MAP kinase-activated protein kinase 2

External ID: CHEMBL3794937

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2016
Volume: 26
Issue: 9
First Page: 2370
Last Page: 2374
DOI: 10.1016/j.bmcl.2016.03.006

Target ChEMBL ID: CHEMBL2208
ChEMBL Target Name: MAP kinase-activated protein kinase 2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	5.1	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mitogen-activated protein kinase 9

External ID: CHEMBL3794936

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2016
Volume: 26
Issue: 9
First Page: 2370
Last Page: 2374
DOI: 10.1016/j.bmcl.2016.03.006

Target ChEMBL ID: CHEMBL4179
ChEMBL Target Name: c-Jun N-terminal kinase 2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	24.5	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：BindingDB 靶标：N/A

External ID: BindingDB_2788_1

Protocol: N/A

Comment: Compounds with any of Ki, IC50, Kd, or EC50 activity value <= 10uM are labeled as "Active".
If multiple measurements are available for a given compound, it is labeled as "Active" if any of the measurements meet the criterion. Activity values are checked in the order of Ki, IC50, Kd, and EC50. The first entry that meets the above activity threshold is used to determine "Standard Type", "Standard Relation", and "PubChem Standard Value". Otherwise, the first non-empty entry will be used to set those values.

Standard Type	PubChem Standard Value	IC50	Target Accession(s)	Ligand	Target
IC50	120	120000	P20248,P24941	BDBM24628	Cyclin-A2/Cyclin-dependent kinase 2
IC50	7	7000	P20248,P24941	BDBM24630	Cyclin-A2/Cyclin-dependent kinase 2
IC50	1.9	1900	P20248,P24941	BDBM24631	Cyclin-A2/Cyclin-dependent kinase 2
IC50	1.5	1500	P20248,P24941	BDBM24632	Cyclin-A2/Cyclin-dependent kinase 2
IC50	0.03	30	P20248,P24941	BDBM24633	Cyclin-A2/Cyclin-dependent kinase 2
IC50	3	3000	P20248,P24941	BDBM24634	Cyclin-A2/Cyclin-dependent kinase 2
IC50	97	97000	P20248,P24941	BDBM24636	Cyclin-A2/Cyclin-dependent kinase 2
IC50	25	25000	P20248,P24941	BDBM24637	Cyclin-A2/Cyclin-dependent kinase 2
IC50	85	85000	P20248,P24941	BDBM24638	Cyclin-A2/Cyclin-dependent kinase 2
IC50	0.85	850	P20248,P24941	BDBM24639	Cyclin-A2/Cyclin-dependent kinase 2
IC50	1.6	1600	P20248,P24941	BDBM24641	Cyclin-A2/Cyclin-dependent kinase 2
IC50	0.025	25	P20248,P24941	BDBM24645	Cyclin-A2/Cyclin-dependent kinase 2
IC50	0.012	12	P20248,P24941	BDBM24646	Cyclin-A2/Cyclin-dependent kinase 2
IC50	0.055	55	P06493,P14635	BDBM24646	Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cyclin-dependent kinase 2

External ID: CHEMBL971698

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2008
Volume: 51
Issue: 16
First Page: 4986
Last Page: 4999
DOI: 10.1021/jm800382h

Target ChEMBL ID: CHEMBL301
ChEMBL Target Name: Cyclin-dependent kinase 2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
1.9	IC50	=	1900	nM
0.044	IC50	=	44	nM
0.75	IC50	=	750	nM
0.35	IC50	=	350	nM
7	IC50	=	7000	nM
1.5	IC50	=	1500	nM
0.03	IC50	=	30	nM
3	IC50	=	3000	nM
0.66	IC50	=	660	nM
85	IC50	=	85000	nM
0.85	IC50	=	850	nM
0.73	IC50	=	730	nM
0.09	IC50	=	90	nM
0.019	IC50	=	19	nM
0.038	IC50	=	38	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cyclin-A2

External ID: CHEMBL3607094

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2015
Volume: 25
Issue: 17
First Page: 3420
Last Page: 3435
DOI: 10.1016/j.bmcl.2015.05.100

Target ChEMBL ID: CHEMBL2094128
ChEMBL Target Name: Cyclin-dependent kinase 2/cyclin A
ChEMBL Target Type: PROTEIN COMPLEX - Target is a defined protein complex, consisting of multiple subunits
Relationship Type: D - Direct protein target assigned
Confidence: Direct protein complex subunits assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.85	IC50	=	850	nM
0.03	IC50	=	30	nM
0.14	IC50	=	140	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Vascular endothelial growth factor receptor 2

External ID: CHEMBL3794771

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2016
Volume: 26
Issue: 9
First Page: 2370
Last Page: 2374
DOI: 10.1016/j.bmcl.2016.03.006

Target ChEMBL ID: CHEMBL279
ChEMBL Target Name: Vascular endothelial growth factor receptor 2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	44.2	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Tyrosine-protein kinase JAK3

External ID: CHEMBL3794770

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2016
Volume: 26
Issue: 9
First Page: 2370
Last Page: 2374
DOI: 10.1016/j.bmcl.2016.03.006

Target ChEMBL ID: CHEMBL2148
ChEMBL Target Name: Tyrosine-protein kinase JAK3
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	51.9	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Tyrosine-protein kinase ITK/TSK

External ID: CHEMBL3794769

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2016
Volume: 26
Issue: 9
First Page: 2370
Last Page: 2374
DOI: 10.1016/j.bmcl.2016.03.006

Target ChEMBL ID: CHEMBL2959
ChEMBL Target Name: Tyrosine-protein kinase ITK/TSK
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	79.7	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Insulin-like growth factor 1 receptor

External ID: CHEMBL3794768

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2016
Volume: 26
Issue: 9
First Page: 2370
Last Page: 2374
DOI: 10.1016/j.bmcl.2016.03.006

Target ChEMBL ID: CHEMBL1957
ChEMBL Target Name: Insulin-like growth factor I receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	18.2	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Protein-tyrosine kinase 2-beta

External ID: CHEMBL3794818

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2016
Volume: 26
Issue: 9
First Page: 2370
Last Page: 2374
DOI: 10.1016/j.bmcl.2016.03.006

Target ChEMBL ID: CHEMBL5469
ChEMBL Target Name: Protein tyrosine kinase 2 beta
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	49.5	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Platelet-derived growth factor receptor alpha

External ID: CHEMBL3794774

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2016
Volume: 26
Issue: 9
First Page: 2370
Last Page: 2374
DOI: 10.1016/j.bmcl.2016.03.006

Target ChEMBL ID: CHEMBL2007
ChEMBL Target Name: Platelet-derived growth factor receptor alpha
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	26.3	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Hepatocyte growth factor receptor

External ID: CHEMBL3794773

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2016
Volume: 26
Issue: 9
First Page: 2370
Last Page: 2374
DOI: 10.1016/j.bmcl.2016.03.006

Target ChEMBL ID: CHEMBL3717
ChEMBL Target Name: Hepatocyte growth factor receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	4.6	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Tyrosine-protein kinase Lck

External ID: CHEMBL3794772

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2016
Volume: 26
Issue: 9
First Page: 2370
Last Page: 2374
DOI: 10.1016/j.bmcl.2016.03.006

Target ChEMBL ID: CHEMBL258
ChEMBL Target Name: Tyrosine-protein kinase LCK
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	5.6	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：High affinity nerve growth factor receptor

External ID: CHEMBL3794822

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2016
Volume: 26
Issue: 9
First Page: 2370
Last Page: 2374
DOI: 10.1016/j.bmcl.2016.03.006

Target ChEMBL ID: CHEMBL2815
ChEMBL Target Name: Nerve growth factor receptor Trk-A
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	95	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Angiopoietin-1 receptor

External ID: CHEMBL3794821

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2016
Volume: 26
Issue: 9
First Page: 2370
Last Page: 2374
DOI: 10.1016/j.bmcl.2016.03.006

Target ChEMBL ID: CHEMBL4128
ChEMBL Target Name: Tyrosine-protein kinase TIE-2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	3	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Tyrosine-protein kinase SYK

External ID: CHEMBL3794820

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2016
Volume: 26
Issue: 9
First Page: 2370
Last Page: 2374
DOI: 10.1016/j.bmcl.2016.03.006

Target ChEMBL ID: CHEMBL2599
ChEMBL Target Name: Tyrosine-protein kinase SYK
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	73.5	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Proto-oncogene tyrosine-protein kinase Src

External ID: CHEMBL3794819

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2016
Volume: 26
Issue: 9
First Page: 2370
Last Page: 2374
DOI: 10.1016/j.bmcl.2016.03.006

Target ChEMBL ID: CHEMBL267
ChEMBL Target Name: Tyrosine-protein kinase SRC
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	6.1	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Aurora kinase A

External ID: CHEMBL3794923

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2016
Volume: 26
Issue: 9
First Page: 2370
Last Page: 2374
DOI: 10.1016/j.bmcl.2016.03.006

Target ChEMBL ID: CHEMBL4722
ChEMBL Target Name: Serine/threonine-protein kinase Aurora-A
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	45.2	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：5'-AMP-activated protein kinase catalytic subunit alpha-1

External ID: CHEMBL3794899

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2016
Volume: 26
Issue: 9
First Page: 2370
Last Page: 2374
DOI: 10.1016/j.bmcl.2016.03.006

Target ChEMBL ID: CHEMBL2096907
ChEMBL Target Name: AMP-activated protein kinase, AMPK
ChEMBL Target Type: PROTEIN COMPLEX GROUP - Target is a poorly defined protein complex, where subunit composition is unclear (e.g., GABA-A receptor)
Relationship Type: D - Direct protein target assigned
Confidence: Multiple direct protein targets may be assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	46	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：RAC-alpha serine/threonine-protein kinase

External ID: CHEMBL3794898

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2016
Volume: 26
Issue: 9
First Page: 2370
Last Page: 2374
DOI: 10.1016/j.bmcl.2016.03.006

Target ChEMBL ID: CHEMBL4282
ChEMBL Target Name: Serine/threonine-protein kinase AKT
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	-2.4	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Tyrosine-protein kinase receptor TYRO3

External ID: CHEMBL3794823

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2016
Volume: 26
Issue: 9
First Page: 2370
Last Page: 2374
DOI: 10.1016/j.bmcl.2016.03.006

Target ChEMBL ID: CHEMBL5314
ChEMBL Target Name: Tyrosine-protein kinase receptor TYRO3
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	10.6	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：B16

External ID: CHEMBL4387644

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem Lett
Year: 2019
Volume: 29
Issue: 18
First Page: 2604
Last Page: 2608
DOI: 10.1016/j.bmcl.2019.07.055

Target ChEMBL ID: CHEMBL381
ChEMBL Target Name: B16
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
38	IC50	=	38000	nM
16	IC50	=	16000	nM
36	IC50	=	36000	nM
15	IC50	=	15000	nM
93	IC50	=	93000	nM
7	IC50	=	7000	nM
51	IC50	=	51000	nM
18	IC50	=	18000	nM
21	IC50	=	21000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Receptor-type tyrosine-protein kinase FLT3

External ID: CHEMBL3794752

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2016
Volume: 26
Issue: 9
First Page: 2370
Last Page: 2374
DOI: 10.1016/j.bmcl.2016.03.006

Target ChEMBL ID: CHEMBL1974
ChEMBL Target Name: Tyrosine-protein kinase receptor FLT3
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.061	IC50	=	61	nM
0.046	IC50	=	46	nM
0.042	IC50	=	42	nM
2	IC50	>	2000	nM
0.552	IC50	=	552	nM
0.443	IC50	=	443	nM
2	IC50	>	2000	nM
0.107	IC50	=	107	nM
2	IC50	>	2000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Epidermal growth factor receptor

External ID: CHEMBL3794763

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2016
Volume: 26
Issue: 9
First Page: 2370
Last Page: 2374
DOI: 10.1016/j.bmcl.2016.03.006

Target ChEMBL ID: CHEMBL203
ChEMBL Target Name: Epidermal growth factor receptor erbB1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	9.1	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Tyrosine-protein kinase CSK

External ID: CHEMBL3794762

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2016
Volume: 26
Issue: 9
First Page: 2370
Last Page: 2374
DOI: 10.1016/j.bmcl.2016.03.006

Target ChEMBL ID: CHEMBL2634
ChEMBL Target Name: Tyrosine-protein kinase CSK
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	-0.5	%

23706-99-2 靶点实验数据