HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Adenosine receptor A2a

External ID: CHEMBL639502

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1986
Volume: 29
Issue: 6
First Page: 989
Last Page: 996
DOI: 10.1021/jm00156a016

Target ChEMBL ID: CHEMBL2094257
ChEMBL Target Name: Adenosine A2 receptor
ChEMBL Target Type: PROTEIN FAMILY - Target is a group of closely related proteins
Relationship Type: H - Homologous protein target assigned
Confidence: Multiple homologous protein targets may be assigned

Standard Type	Standard Relation	Standard Value
MPR	=	4.3
MPR	=	0.04

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL638342

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1986
Volume: 29
Issue: 6
First Page: 989
Last Page: 996
DOI: 10.1021/jm00156a016

Standard Type	Standard Relation	Standard Value
k'	=	2.76
k'	=	6.27
k'	=	2.57
k'	=	2.61
k'	=	3.36
k'	=	8.29
k'	=	2.92
k'	=	2.31
k'	=	1.66
k'	=	1.21
k'	=	1.29
k'	=	0.85
k'	=	1.77
k'	=	6.93
k'	=	2.75

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Adenosine receptor A2a

External ID: CHEMBL639504

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1986
Volume: 29
Issue: 6
First Page: 989
Last Page: 996
DOI: 10.1021/jm00156a016

Target ChEMBL ID: CHEMBL2094257
ChEMBL Target Name: Adenosine A2 receptor
ChEMBL Target Type: PROTEIN FAMILY - Target is a group of closely related proteins
Relationship Type: H - Homologous protein target assigned
Confidence: Multiple homologous protein targets may be assigned

Standard Type	Standard Relation	Standard Value
pka	=	3.22
pka	=	3.3
pka	=	3.06
pka	=	3.07
pka	=	2.73
pka	=	3.57

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Amaranthus

External ID: CHEMBL905598

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2007
Volume: 15
Issue: 11
First Page: 3737
Last Page: 3747
DOI: 10.1016/j.bmc.2007.03.038

Target ChEMBL ID: CHEMBL614996
ChEMBL Target Name: Amaranthus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	102	%
Activity	=	99	%
Activity	=	98	%
Activity	=	17	%
Activity	=	18	%
Activity	=	93	%
Activity	=	14	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Nicotiana tabacum

External ID: CHEMBL905604

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2007
Volume: 15
Issue: 11
First Page: 3737
Last Page: 3747
DOI: 10.1016/j.bmc.2007.03.038

Target ChEMBL ID: CHEMBL613059
ChEMBL Target Name: Nicotiana tabacum
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	45	%
Activity	=	98	%
Activity	=	90	%
Activity	=	92	%
Activity	=	2	%
Activity	=	85	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Phosphoglycerate kinase 1

External ID: CHEMBL766247

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2000
Volume: 43
Issue: 22
First Page: 4135
Last Page: 4150
DOI: 10.1021/jm000287a

Target ChEMBL ID: CHEMBL2096677
ChEMBL Target Name: Phosphoglycerate kinase
ChEMBL Target Type: PROTEIN FAMILY - Target is a group of closely related proteins
Relationship Type: H - Homologous protein target assigned
Confidence: Multiple homologous protein targets may be assigned

Standard Type	Standard Units	Activity Comment
IC50	nM	Not Active
IC50	nM	Not Active
IC50	nM	Not Active
IC50	nM	Not Active
IC50	nM	Not Active
IC50	nM	Not Active
IC50	nM	Not Active
IC50	nM	Not Active
IC50	nM	Not Active
IC50	nM	Not Active
IC50	nM	Not Active
IC50	nM	Not Active
IC50	nM	Not Active
IC50	nM	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Histidine kinase 3

External ID: CHEMBL905605

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2007
Volume: 15
Issue: 11
First Page: 3737
Last Page: 3747
DOI: 10.1016/j.bmc.2007.03.038

Target ChEMBL ID: CHEMBL6125
ChEMBL Target Name: Histidine kinase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	2.63	%
Activity	=	0.04	%
Activity	=	1.12	%
Activity	=	2.45	%
Activity	=	2.53	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Histidine kinase 4

External ID: CHEMBL905606

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2007
Volume: 15
Issue: 11
First Page: 3737
Last Page: 3747
DOI: 10.1016/j.bmc.2007.03.038

Target ChEMBL ID: CHEMBL6124
ChEMBL Target Name: Histidine kinase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	0.15	%
Activity	=	0.12	%
Activity	=	0.14	%
Activity	=	0.22	%
Activity	=	0.35	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Triticum aestivum

External ID: CHEMBL905600

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2007
Volume: 15
Issue: 11
First Page: 3737
Last Page: 3747
DOI: 10.1016/j.bmc.2007.03.038

Target ChEMBL ID: CHEMBL612836
ChEMBL Target Name: Triticum aestivum
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	58	%
Activity	=	141	%
Activity	=	72	%
Activity	=	143	%
Activity	=	198	%
Activity	=	209	%
Activity	=	65.5	%
Activity	=	10	%
Activity	=	95	%
Activity	=	52	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HL-60

External ID: CHEMBL905611

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2007
Volume: 15
Issue: 11
First Page: 3737
Last Page: 3747
DOI: 10.1016/j.bmc.2007.03.038

Target ChEMBL ID: CHEMBL383
ChEMBL Target Name: HL-60
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
0.92	IC50	=	920	nM
1.2	IC50	=	1200	nM
4.9	IC50	=	4900	nM
96.3	IC50	=	96300	nM
2	IC50	=	2000	nM
166.7	IC50	>	166700	nM		Outside typical range
	IC50				Not Determined
	IC50				Not Determined
	IC50				Not Determined

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：G-361

External ID: CHEMBL904600

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2007
Volume: 15
Issue: 11
First Page: 3737
Last Page: 3747
DOI: 10.1016/j.bmc.2007.03.038

Target ChEMBL ID: CHEMBL614036
ChEMBL Target Name: G-361
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
166.7	IC50	>	166700	nM		Outside typical range
166.7	IC50	>	166700	nM		Outside typical range
	IC50				Not Determined
128.3	IC50	=	128300	nM		Outside typical range
144.7	IC50	=	144700	nM		Outside typical range
	IC50				Not Determined
16.9	IC50	=	16900	nM
166.7	IC50	>	166700	nM		Outside typical range
166.7	IC50	>	166700	nM		Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：B16

External ID: CHEMBL904601

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2007
Volume: 15
Issue: 11
First Page: 3737
Last Page: 3747
DOI: 10.1016/j.bmc.2007.03.038

Target ChEMBL ID: CHEMBL381
ChEMBL Target Name: B16
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
	IC50				Not Determined
	IC50				Not Determined
166.7	IC50	>	166700	nM		Outside typical range
166.7	IC50	>	166700	nM		Outside typical range
166.7	IC50	>	166700	nM		Outside typical range
	IC50				Not Determined
	IC50				Not Determined
	IC50				Not Determined
	IC50				Not Determined

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL904602

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2007
Volume: 15
Issue: 11
First Page: 3737
Last Page: 3747
DOI: 10.1016/j.bmc.2007.03.038

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
84	IC50	=	84000	nM
44.3	IC50	=	44300	nM
166.7	IC50	>	166700	nM		Outside typical range
	IC50				Not Determined
	IC50				Not Determined
	IC50				Not Determined
	IC50				Not Determined
	IC50				Not Determined
	IC50				Not Determined

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HOS

External ID: CHEMBL905607

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2007
Volume: 15
Issue: 11
First Page: 3737
Last Page: 3747
DOI: 10.1016/j.bmc.2007.03.038

Target ChEMBL ID: CHEMBL614736
ChEMBL Target Name: HOS
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
166.7	IC50	>	166700	nM	Outside typical range
13.2	IC50	=	13200	nM
166.7	IC50	>	166700	nM	Outside typical range
166.7	IC50	>	166700	nM	Outside typical range
166.7	IC50	>	166700	nM	Outside typical range
166.7	IC50	>	166700	nM	Outside typical range
166.7	IC50	>	166700	nM	Outside typical range
166.7	IC50	>	166700	nM	Outside typical range
166.7	IC50	>	166700	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：K562

External ID: CHEMBL905608

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2007
Volume: 15
Issue: 11
First Page: 3737
Last Page: 3747
DOI: 10.1016/j.bmc.2007.03.038

Target ChEMBL ID: CHEMBL385
ChEMBL Target Name: K562
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
7.6	IC50	=	7600	nM
2.7	IC50	=	2700	nM
166.7	IC50	>	166700	nM	Outside typical range
106	IC50	=	106000	nM	Outside typical range
10.8	IC50	=	10800	nM
166.7	IC50	>	166700	nM	Outside typical range
25.8	IC50	=	25800	nM
166.7	IC50	>	166700	nM	Outside typical range
166.7	IC50	>	166700	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL905609

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2007
Volume: 15
Issue: 11
First Page: 3737
Last Page: 3747
DOI: 10.1016/j.bmc.2007.03.038

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
15.3	IC50	=	15300	nM
21	IC50	=	21000	nM
166.7	IC50	>	166700	nM	Outside typical range
126.9	IC50	=	126900	nM	Outside typical range
88.8	IC50	=	88800	nM
166.7	IC50	>	166700	nM	Outside typical range
5.2	IC50	=	5200	nM
166.7	IC50	>	166700	nM	Outside typical range
166.7	IC50	>	166700	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：CCRF-CEM

External ID: CHEMBL905610

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2007
Volume: 15
Issue: 11
First Page: 3737
Last Page: 3747
DOI: 10.1016/j.bmc.2007.03.038

Target ChEMBL ID: CHEMBL382
ChEMBL Target Name: CCRF-CEM
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
4	IC50	=	4000	nM
1.25	IC50	=	1250	nM
7.6	IC50	=	7600	nM
86.7	IC50	=	86700	nM
3.8	IC50	=	3800	nM
166.7	IC50	>	166700	nM		Outside typical range
	IC50				Not Determined
	IC50				Not Determined
	IC50				Not Determined

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Adenosine kinase

External ID: CHEMBL3063318

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Med Chem Res
Year: 2012
Volume: 21
Issue: 5
First Page: 590
Last Page: 600
DOI: 10.1007/s00044-011-9554-z

Target ChEMBL ID: CHEMBL2982
ChEMBL Target Name: Adenosine kinase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
8.10961	IC50	=	8109.61	nM
8.11	IC50	=	8110	nM
2.1	Ki	=	2100	nM
8.70964	IC50	=	8709.64	nM
8.7	IC50	=	8700	nM
2.9	Ki	=	2900	nM
6.69885	IC50	=	6698.85	nM
6.7	IC50	=	6700	nM
1.4	Ki	=	1400	nM
10.5	IC50	=	10500	nM
8.70964	IC50	=	8709.64	nM
7.5	IC50	=	7500	nM
9.28966	IC50	=	9289.66	nM
9.3	IC50	=	9300	nM
14.2889	IC50	=	14288.94	nM
14.9969	IC50	=	14996.85	nM
15	IC50	=	15000	nM
21.9786	IC50	=	21978.6	nM
9.5	IC50	=	9500	nM
14.9969	IC50	=	14996.85	nM

23666-24-2 靶点实验数据