HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL632347

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2000
Volume: 10
Issue: 18
First Page: 2051
Last Page: 2054
DOI: 10.1016/s0960-894x(00)00272-9

Standard Type	Standard Relation	Standard Value
CLogP	=	5.96
CLogP	=	4.76
CLogP	=	5.99

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mitogen-activated protein kinase 14

External ID: CHEMBL731498

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2000
Volume: 10
Issue: 18
First Page: 2051
Last Page: 2054
DOI: 10.1016/s0960-894x(00)00272-9

Target ChEMBL ID: CHEMBL260
ChEMBL Target Name: MAP kinase p38 alpha
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.29	IC50	=	290	nM
0.044	IC50	=	44	nM
0.18	IC50	=	180	nM
0.029	IC50	=	29	nM
0.035	IC50	=	35	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mitogen-activated protein kinase 3

External ID: CHEMBL732083

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2000
Volume: 10
Issue: 18
First Page: 2051
Last Page: 2054
DOI: 10.1016/s0960-894x(00)00272-9

Target ChEMBL ID: CHEMBL3385
ChEMBL Target Name: MAP kinase ERK1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	0	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL632715

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2000
Volume: 10
Issue: 18
First Page: 2051
Last Page: 2054
DOI: 10.1016/s0960-894x(00)00272-9

Standard Type	Standard Relation	Standard Value	Standard Units
Solubility	=	24	ug.mL-1
Solubility	=	594	ug.mL-1
Solubility	=	46	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：SW1353

External ID: CHEMBL802289

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2000
Volume: 10
Issue: 18
First Page: 2051
Last Page: 2054
DOI: 10.1016/s0960-894x(00)00272-9

Target ChEMBL ID: CHEMBL614944
ChEMBL Target Name: SW1353
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.025	IC50	=	25	nM
0.148	IC50	=	148	nM

227622-98-2 靶点实验数据