HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：G1/S-specific cyclin-E2

External ID: CHEMBL654688

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2001
Volume: 11
Issue: 9
First Page: 1157
Last Page: 1160
DOI: 10.1016/s0960-894x(01)00185-8

Target ChEMBL ID: CHEMBL2094126
ChEMBL Target Name: Cyclin-dependent kinase 2/cyclin E
ChEMBL Target Type: PROTEIN COMPLEX - Target is a defined protein complex, consisting of multiple subunits
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous protein complex subunits assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
0.7	IC50	=	700	nM
6.8	IC50	=	6800	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：BindingDB 靶标：N/A

External ID: BindingDB_896_1

Protocol: N/A

Comment: Compounds with any of Ki, IC50, Kd, or EC50 activity value <= 10uM are labeled as "Active".
If multiple measurements are available for a given compound, it is labeled as "Active" if any of the measurements meet the criterion. Activity values are checked in the order of Ki, IC50, Kd, and EC50. The first entry that meets the above activity threshold is used to determine "Standard Type", "Standard Relation", and "PubChem Standard Value". Otherwise, the first non-empty entry will be used to set those values.

Standard Type	Standard Relation	PubChem Standard Value	IC50 Qualifier	IC50	Target Accession(s)	Ligand	Target
IC50	>	34	>	34000	P24864,P24941	BDBM6971	Cyclin-dependent kinase 2/G1/S-specific cyclin-E1
IC50		16.8		16800	P11802,P24385	BDBM6972	Cyclin-dependent kinase 4/G1/S-specific cyclin-D1
IC50		14.8		14800	P24864,P24941	BDBM6976	Cyclin-dependent kinase 2/G1/S-specific cyclin-E1
IC50		15		15000	P11802,P24385	BDBM6977	Cyclin-dependent kinase 4/G1/S-specific cyclin-D1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cyclin-dependent kinase 4

External ID: CHEMBL659123

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2001
Volume: 11
Issue: 9
First Page: 1157
Last Page: 1160
DOI: 10.1016/s0960-894x(01)00185-8

Target ChEMBL ID: CHEMBL1907601
ChEMBL Target Name: Cyclin-dependent kinase 4/cyclin D1
ChEMBL Target Type: PROTEIN COMPLEX - Target is a defined protein complex, consisting of multiple subunits
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous protein complex subunits assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
11	IC50	=	11000	nM
19	IC50	>	19000	nM

22754-18-3 靶点实验数据