HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL1039306

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2009
Volume: 17
Issue: 14
First Page: 5275
Last Page: 5284
DOI: 10.1016/j.bmc.2009.05.039

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Survival	=	0	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Proteasome subunit beta type-8

External ID: CHEMBL4822209

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2021
Volume: 219
First Page: 113455
Last Page: 113455
DOI: 10.1016/j.ejmech.2021.113455

Target ChEMBL ID: CHEMBL5620
ChEMBL Target Name: Proteasome subunit beta type-8
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	55	%
Activity	=	69	%
Activity	=	80	%
Activity	=	88	%
Activity	=	58	%
Activity	=	61	%
Activity	=	40	%
Activity	=	89	%
Activity	=	99	%
Activity	=	87	%
Activity	=	56	%
Activity	=	59	%
Activity	=	99	%
Activity	=	50	%
Activity	=	63	%
Activity	=	73	%
Activity	=	44	%
Activity	=	52	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL1039289

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2009
Volume: 17
Issue: 14
First Page: 5275
Last Page: 5284
DOI: 10.1016/j.bmc.2009.05.039

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Survival	=	100	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL1037511

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2009
Volume: 17
Issue: 14
First Page: 5275
Last Page: 5284
DOI: 10.1016/j.bmc.2009.05.039

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
LD50	=	800	mg.kg-1
LD50	>	960	mg.kg-1
LD50	>	520	mg.kg-1
LD50	=	698	mg.kg-1
LD50	>	680	mg.kg-1
LD50	>	616	mg.kg-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL1037510

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2009
Volume: 17
Issue: 14
First Page: 5275
Last Page: 5284
DOI: 10.1016/j.bmc.2009.05.039

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
51.85	IC50	=	51850	nM
	IC50				ND(Insoluble)
21.26	IC50	=	21260	nM
1520	IC50	=	1520000	nM		Outside typical range
4040	IC50	=	4040000	nM		Outside typical range
	IC50				ND(Insoluble)
390	IC50	=	390000	nM		Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1037508

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2009
Volume: 17
Issue: 14
First Page: 5275
Last Page: 5284
DOI: 10.1016/j.bmc.2009.05.039

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
4000	IC50	>	4000000	nM	Outside typical range
92	IC50	=	92000	nM
96	IC50	=	96000	nM
20	IC50	=	20000	nM
1400	IC50	=	1400000	nM	Outside typical range
3500	IC50	=	3500000	nM	Outside typical range
2400	IC50	=	2400000	nM	Outside typical range
4000	IC50	>	4000000	nM	Outside typical range
4000	IC50	>	4000000	nM	Outside typical range
4000	IC50	>	4000000	nM	Outside typical range
4000	IC50	>	4000000	nM	Outside typical range
91	IC50	=	91000	nM
46	IC50	=	46000	nM
53	IC50	=	53000	nM
84	IC50	=	84000	nM
1390	IC50	=	1390000	nM	Outside typical range
3170	IC50	=	3170000	nM	Outside typical range
110	IC50	=	110000	nM	Outside typical range
4000	IC50	>	4000000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4822220

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2021
Volume: 219
First Page: 113455
Last Page: 113455
DOI: 10.1016/j.ejmech.2021.113455

Standard Type	Standard Text Value
solubility	Insoluble

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL1039294

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2009
Volume: 17
Issue: 14
First Page: 5275
Last Page: 5284
DOI: 10.1016/j.bmc.2009.05.039

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Survival	=	80	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL1039295

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2009
Volume: 17
Issue: 14
First Page: 5275
Last Page: 5284
DOI: 10.1016/j.bmc.2009.05.039

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Survival	=	0	%

2268-79-3 靶点实验数据