HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cyclin-K

External ID: CHEMBL4264037

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur J Med Chem
Year: 2018
Volume: 158
First Page: 896
Last Page: 916
DOI: 10.1016/j.ejmech.2018.09.025

Target ChEMBL ID: CHEMBL3038475
ChEMBL Target Name: CDK9/Cyclin K
ChEMBL Target Type: PROTEIN COMPLEX - Target is a defined protein complex, consisting of multiple subunits
Relationship Type: D - Direct protein target assigned
Confidence: Direct protein complex subunits assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.114	IC50	=	114	nM
0.027	IC50	=	27	nM
0.094	IC50	=	94	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4264036

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur J Med Chem
Year: 2018
Volume: 158
First Page: 896
Last Page: 916
DOI: 10.1016/j.ejmech.2018.09.025

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
1.2	GI50	=	1200	nM
8	GI50	=	8000	nM
2.04	GI50	=	2040	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4264035

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur J Med Chem
Year: 2018
Volume: 158
First Page: 896
Last Page: 916
DOI: 10.1016/j.ejmech.2018.09.025

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.27	GI50	=	270	nM
2.5	GI50	=	2500	nM
0.85	GI50	=	850	nM
6.31	GI50	=	6310	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：MV4-11

External ID: CHEMBL4264034

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur J Med Chem
Year: 2018
Volume: 158
First Page: 896
Last Page: 916
DOI: 10.1016/j.ejmech.2018.09.025

Target ChEMBL ID: CHEMBL613835
ChEMBL Target Name: MV4-11
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.91	GI50	=	910	nM
0.82	GI50	=	820	nM
3.46	GI50	=	3460	nM

2247481-22-5 靶点实验数据