HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Bromodomain-containing protein 4

External ID: CHEMBL5060944

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL1163125
ChEMBL Target Name: Bromodomain-containing protein 4
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value	Standard Units
Delta TM	=	-3.51	C
Delta TM	=	-12.67	C
Delta TM	=	-0.61	C
Delta TM	=	1.2	C
Delta TM	=	-2.16	C
Delta TM	=	-11.41	C
Delta TM	=	-0.76	C
Delta TM	=	-4.31	C
Delta TM	=	3.95	C
Delta TM	=	-0.38	C
Delta TM	=	-2.21	C
Delta TM	=	0.44	C
Delta TM	=	-2.86	C
Delta TM	=	0.42	C
Delta TM	=	-0.39	C
Delta TM	=	1.17	C
Delta TM	=	-2.45	C
Delta TM	=	-1.48	C
Delta TM	=	-0.92	C
Delta TM	=	-2.44	C

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Peregrin

External ID: CHEMBL4650107

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL3132741
ChEMBL Target Name: Peregrin
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Delta TM	=	-1.78	C
Delta TM	=	-1.51	C	Thermal Shift Assay
Delta TM	=	-1.41	C	Thermal Shift Assay
Delta TM	=	-1.6	C
Delta TM	=	-2.24	C	Thermal Shift Assay
Delta TM	=	-2.09	C	Thermal Shift Assay
Delta TM	=	-2.28	C	Thermal Shift Assay
Delta TM	=	-1.96	C	Thermal Shift Assay
Delta TM	=	-1.24	C	Thermal Shift Assay
Delta TM	=	-1.64	C	Thermal Shift Assay
Delta TM	=	-3.24	C
Delta TM	=	-2.18	C	Thermal Shift Assay
Delta TM	=	-2.03	C
Delta TM	=	-1.92	C	Thermal Shift Assay
Delta TM	=	-2.24	C
Delta TM	=	-2.19	C	Thermal Shift Assay
Delta TM	=	-2.72	C
Delta TM	=	-1.9	C	Thermal Shift Assay
Delta TM	=	0	C
Delta TM	=	-0.4	C

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cyclin-dependent kinase 2

External ID: CHEMBL5062802

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL301
ChEMBL Target Name: Cyclin-dependent kinase 2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Delta TM	=	0.1409	C	Thermal Shift Assay
Delta TM	=	-0.01457	C	Thermal Shift Assay
Delta TM	=	-0.19	C
Delta TM	=	1.16	C	Thermal Shift Assay
Delta TM	=	1.921	C	Thermal Shift Assay
Delta TM	=	-0.3406	C	Thermal Shift Assay
Delta TM	=	0.6	C	Thermal Shift Assay
Delta TM	=	-0.1127	C	Thermal Shift Assay
Delta TM	=	-1.169	C	Thermal Shift Assay
Delta TM	=	0.82	C
Delta TM	=	0.31	C	Thermal Shift Assay
Delta TM	=	-0.02	C	Thermal Shift Assay
Delta TM	=	0.46	C	Thermal Shift Assay
Delta TM	=	-1.475	C	Thermal Shift Assay
Delta TM	=	-0.6313	C	Thermal Shift Assay
Delta TM	=	0	C	Thermal Shift Assay
Delta TM	=	-0.6762	C	Thermal Shift Assay
Delta TM	=	1.46	C	Thermal Shift Assay
Delta TM	=	0.98	C	Thermal Shift Assay
Delta TM	=	0.83	C	Thermal Shift Assay

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Son of sevenless homolog 1

External ID: CHEMBL4201763

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2018
Volume: 61
Issue: 19
First Page: 8875
Last Page: 8894
DOI: 10.1021/acs.jmedchem.8b01108

Target ChEMBL ID: CHEMBL2079846
ChEMBL Target Name: Son of sevenless homolog 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Son of sevenless homolog 1

External ID: CHEMBL4201762

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2018
Volume: 61
Issue: 19
First Page: 8875
Last Page: 8894
DOI: 10.1021/acs.jmedchem.8b01108

Target ChEMBL ID: CHEMBL2079846
ChEMBL Target Name: Son of sevenless homolog 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Son of sevenless homolog 1

External ID: CHEMBL4201764

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2018
Volume: 61
Issue: 19
First Page: 8875
Last Page: 8894
DOI: 10.1021/acs.jmedchem.8b01108

Target ChEMBL ID: CHEMBL2079846
ChEMBL Target Name: Son of sevenless homolog 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Aurora kinase A

External ID: CHEMBL5067447

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL4722
ChEMBL Target Name: Serine/threonine-protein kinase Aurora-A
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Delta TM	=	0.05675	C	Thermal Shift Assay
Delta TM	=	0.06056	C	Thermal Shift Assay
Delta TM	=	-0.26	C
Delta TM	=	0.05	C	Thermal Shift Assay
Delta TM	=	0.2158	C	Thermal Shift Assay
Delta TM	=	0.1132	C	Thermal Shift Assay
Delta TM	=	-0.21	C	Thermal Shift Assay
Delta TM	=	0.07973	C	Thermal Shift Assay
Delta TM	=	0.3724	C	Thermal Shift Assay
Delta TM	=	-0.3	C
Delta TM	=	-0.04	C	Thermal Shift Assay
Delta TM	=	-0.08	C	Thermal Shift Assay
Delta TM	=	-0.49	C	Thermal Shift Assay
Delta TM	=	0.08515	C	Thermal Shift Assay
Delta TM	=	0.01057	C	Thermal Shift Assay
Delta TM	=	0	C	Thermal Shift Assay
Delta TM	=	0.1944	C	Thermal Shift Assay
Delta TM	=	2.51	C	Thermal Shift Assay
Delta TM	=	-0.01	C	Thermal Shift Assay
Delta TM	=	-0.24	C	Thermal Shift Assay

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Casein kinase I isoform delta

External ID: CHEMBL5063731

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL2828
ChEMBL Target Name: Casein kinase I delta
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Delta TM	=	6.701	C	Thermal Shift Assay
Delta TM	=	-0.2558	C	Thermal Shift Assay
Delta TM	=	-0.1	C
Delta TM	=	0	C	Thermal Shift Assay
Delta TM	=	0.7084	C	Thermal Shift Assay
Delta TM	=	0.1261	C	Thermal Shift Assay
Delta TM	=	-0.03	C	Thermal Shift Assay
Delta TM	=	-0.01222	C	Thermal Shift Assay
Delta TM	=	0.1456	C	Thermal Shift Assay
Delta TM	=	0.25	C
Delta TM	=	0.37	C	Thermal Shift Assay
Delta TM	=	0.18	C	Thermal Shift Assay
Delta TM	=	0.03	C	Thermal Shift Assay
Delta TM	=	-0.1697	C	Thermal Shift Assay
Delta TM	=	0.01025	C	Thermal Shift Assay
Delta TM	=	0.1725	C	Thermal Shift Assay
Delta TM	=	-0.1915	C	Thermal Shift Assay
Delta TM	=	1.62	C	Thermal Shift Assay
Delta TM	=	1.03	C	Thermal Shift Assay
Delta TM	=	-0.03	C	Thermal Shift Assay

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Glycogen synthase kinase-3 beta

External ID: CHEMBL5065589

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL262
ChEMBL Target Name: Glycogen synthase kinase-3 beta
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Delta TM	=	5.443	C	Thermal Shift Assay
Delta TM	=	-0.3085	C	Thermal Shift Assay
Delta TM	=	-0.7	C
Delta TM	=	-0.03	C	Thermal Shift Assay
Delta TM	=	11.17	C	Thermal Shift Assay
Delta TM	=	-1.553	C	Thermal Shift Assay
Delta TM	=	-0.29	C	Thermal Shift Assay
Delta TM	=	-0.3615	C	Thermal Shift Assay
Delta TM	=	0.0664	C	Thermal Shift Assay
Delta TM	=	-0.66	C
Delta TM	=	-0.06	C	Thermal Shift Assay
Delta TM	=	-0.21	C	Thermal Shift Assay
Delta TM	=	-0.26	C	Thermal Shift Assay
Delta TM	=	-1.145	C	Thermal Shift Assay
Delta TM	=	-0.6697	C	Thermal Shift Assay
Delta TM	=	0	C	Thermal Shift Assay
Delta TM	=	-0.4876	C	Thermal Shift Assay
Delta TM	=	2.74	C	Thermal Shift Assay
Delta TM	=	0.22	C	Thermal Shift Assay
Delta TM	=	-0.06	C	Thermal Shift Assay

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Tyrosine-protein kinase ABL1

External ID: CHEMBL5060015

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL1862
ChEMBL Target Name: Tyrosine-protein kinase ABL
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Delta TM	=	2.866	C	Thermal Shift Assay
Delta TM	=	-0.1161	C	Thermal Shift Assay
Delta TM	=	0.32	C
Delta TM	=	0.12	C	Thermal Shift Assay
Delta TM	=	1.321	C	Thermal Shift Assay
Delta TM	=	-0.3289	C	Thermal Shift Assay
Delta TM	=	0.97	C	Thermal Shift Assay
Delta TM	=	-0.00477	C	Thermal Shift Assay
Delta TM	=	0.8545	C	Thermal Shift Assay
Delta TM	=	0.25	C
Delta TM	=	0.05	C	Thermal Shift Assay
Delta TM	=	0.01	C	Thermal Shift Assay
Delta TM	=	0.57	C	Thermal Shift Assay
Delta TM	=	-0.2514	C	Thermal Shift Assay
Delta TM	=	-0.09405	C	Thermal Shift Assay
Delta TM	=	0.1211	C	Thermal Shift Assay
Delta TM	=	0.2152	C	Thermal Shift Assay
Delta TM	=	4.95	C	Thermal Shift Assay
Delta TM	=	0.78	C	Thermal Shift Assay
Delta TM	=	0.49	C	Thermal Shift Assay

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Son of sevenless homolog 1

External ID: CHEMBL4201753

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2018
Volume: 61
Issue: 19
First Page: 8875
Last Page: 8894
DOI: 10.1021/acs.jmedchem.8b01108

Target ChEMBL ID: CHEMBL2079846
ChEMBL Target Name: Son of sevenless homolog 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.009	Kd	=	9	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Fibroblast

External ID: CHEMBL4725213

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL5314315
ChEMBL Target Name: Fibroblast
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value
Growth Rate	=	-0.32
Growth Rate	=	-0.85
Growth Rate	=	0.66
Growth Rate	=	0.58
Growth Rate	=	0.86
Growth Rate	=	0.06
Growth Rate	=	0.1
Growth Rate	=	0.63
Growth Rate	=	0.67
Growth Rate	=	0.46
Growth Rate	=	0.87
Growth Rate	=	0
Growth Rate	=	0.46
Growth Rate	=	0.87
Growth Rate	=	-0.42
Growth Rate	=	-0.57
Growth Rate	=	-0.81
Growth Rate	=	0.2
Growth Rate	=	0.77
Growth Rate	=	0.4

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5160190

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 5.0
First Page: 3923
Last Page: 3942
DOI: 10.1021/acs.jmedchem.1c01774

Standard Type	Activity Comment
Activity	Active
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HEK-293T

External ID: CHEMBL4725212

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL3706568
ChEMBL Target Name: HEK-293T
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value
Growth Rate	=	0.66
Growth Rate	=	0.47
Growth Rate	=	0.81
Growth Rate	=	0.62
Growth Rate	=	0.92
Growth Rate	=	0.99
Growth Rate	=	-0.15
Growth Rate	=	-0.01
Growth Rate	=	0.69
Growth Rate	=	0.27
Growth Rate	=	0.71
Growth Rate	=	0.38
Growth Rate	=	0.78
Growth Rate	=	0.46
Growth Rate	=	0.9
Growth Rate	=	0.97
Growth Rate	=	0.97
Growth Rate	=	0.5
Growth Rate	=	0.33
Growth Rate	=	0.54

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Son of sevenless homolog 1

External ID: CHEMBL5514036

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur J Med Chem
Year: 2024
Volume: 268
First Page: 116282
Last Page: 116282
DOI: 10.1016/j.ejmech.2024.116282

Target ChEMBL ID: CHEMBL2079846
ChEMBL Target Name: Son of sevenless homolog 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.01	Kd	<	10	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：U2OS

External ID: CHEMBL4725214

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL615023
ChEMBL Target Name: U2OS
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value
Growth Rate	=	0.94
Growth Rate	=	0.96
Growth Rate	=	0.56
Growth Rate	=	0.78
Growth Rate	=	0.8
Growth Rate	=	0.92
Growth Rate	=	0.78
Growth Rate	=	-0.28
Growth Rate	=	-0.1
Growth Rate	=	0.54
Growth Rate	=	0.58
Growth Rate	=	0.72
Growth Rate	=	0.97
Growth Rate	=	0.76
Growth Rate	=	0.97
Growth Rate	=	0.82
Growth Rate	=	0.75
Growth Rate	=	0.87
Growth Rate	=	0.77
Growth Rate	=	0.78

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Son of sevenless homolog 1

External ID: CHEMBL4201759

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2018
Volume: 61
Issue: 19
First Page: 8875
Last Page: 8894
DOI: 10.1021/acs.jmedchem.8b01108

Target ChEMBL ID: CHEMBL2079846
ChEMBL Target Name: Son of sevenless homolog 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	Active
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Son of sevenless homolog 1

External ID: CHEMBL4201758

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2018
Volume: 61
Issue: 19
First Page: 8875
Last Page: 8894
DOI: 10.1021/acs.jmedchem.8b01108

Target ChEMBL ID: CHEMBL2079846
ChEMBL Target Name: Son of sevenless homolog 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	Active
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Son of sevenless homolog 1

External ID: CHEMBL4201761

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2018
Volume: 61
Issue: 19
First Page: 8875
Last Page: 8894
DOI: 10.1021/acs.jmedchem.8b01108

Target ChEMBL ID: CHEMBL2079846
ChEMBL Target Name: Son of sevenless homolog 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	Active
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Son of sevenless homolog 1

External ID: CHEMBL4201760

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2018
Volume: 61
Issue: 19
First Page: 8875
Last Page: 8894
DOI: 10.1021/acs.jmedchem.8b01108

Target ChEMBL ID: CHEMBL2079846
ChEMBL Target Name: Son of sevenless homolog 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	Active
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Son of sevenless homolog 1

External ID: CHEMBL4201755

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2018
Volume: 61
Issue: 19
First Page: 8875
Last Page: 8894
DOI: 10.1021/acs.jmedchem.8b01108

Target ChEMBL ID: CHEMBL2079846
ChEMBL Target Name: Son of sevenless homolog 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
11.4	EC50	=	11400	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4201757

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2018
Volume: 61
Issue: 19
First Page: 8875
Last Page: 8894
DOI: 10.1021/acs.jmedchem.8b01108

Standard Type	Standard Relation	Standard Value	Standard Units
Solubility	>	110	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Son of sevenless homolog 1

External ID: CHEMBL4201756

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2018
Volume: 61
Issue: 19
First Page: 8875
Last Page: 8894
DOI: 10.1021/acs.jmedchem.8b01108

Target ChEMBL ID: CHEMBL2079846
ChEMBL Target Name: Son of sevenless homolog 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
15.7	EC50	=	15700	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Transcription intermediary factor 1-alpha

External ID: CHEMBL5068376

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL3108638
ChEMBL Target Name: Transcription intermediary factor 1-alpha
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Delta TM	=	-1.063	C	Thermal Shift Assay
Delta TM	=	-1.635	C	Thermal Shift Assay
Delta TM	=	-0.81	C
Delta TM	=	-1.89	C	Thermal Shift Assay
Delta TM	=	-1.777	C	Thermal Shift Assay
Delta TM	=	-0.6282	C	Thermal Shift Assay
Delta TM	=	0.05	C	Thermal Shift Assay
Delta TM	=	-0.9401	C	Thermal Shift Assay
Delta TM	=	-10.19	C	Thermal Shift Assay
Delta TM	=	-2.64	C
Delta TM	=	-3.32	C	Thermal Shift Assay
Delta TM	=	-1.35	C	Thermal Shift Assay
Delta TM	=	-0.62	C	Thermal Shift Assay
Delta TM	=	-1.882	C	Thermal Shift Assay
Delta TM	=	-1.86	C	Thermal Shift Assay
Delta TM	=	0	C	Thermal Shift Assay
Delta TM	=	-0.2469	C	Thermal Shift Assay
Delta TM	=	-1.62	C	Thermal Shift Assay
Delta TM	=	-0.04	C	Thermal Shift Assay
Delta TM	=	0.09	C	Thermal Shift Assay

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Fibroblast growth factor receptor 3

External ID: CHEMBL5064660

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL2742
ChEMBL Target Name: Fibroblast growth factor receptor 3
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Delta TM	=	0.7492	C	Thermal Shift Assay
Delta TM	=	0.2121	C	Thermal Shift Assay
Delta TM	=	0.26	C
Delta TM	=	0.23	C	Thermal Shift Assay
Delta TM	=	1.695	C	Thermal Shift Assay
Delta TM	=	0.0801	C	Thermal Shift Assay
Delta TM	=	0.12	C	Thermal Shift Assay
Delta TM	=	0.00436	C	Thermal Shift Assay
Delta TM	=	-0.4219	C	Thermal Shift Assay
Delta TM	=	0.59	C
Delta TM	=	0.07	C	Thermal Shift Assay
Delta TM	=	0.13	C	Thermal Shift Assay
Delta TM	=	0.01	C	Thermal Shift Assay
Delta TM	=	0.04669	C	Thermal Shift Assay
Delta TM	=	0.09916	C	Thermal Shift Assay
Delta TM	=	0	C	Thermal Shift Assay
Delta TM	=	0	C	Thermal Shift Assay
Delta TM	=	1.03	C	Thermal Shift Assay
Delta TM	=	0.41	C	Thermal Shift Assay
Delta TM	=	0.25	C	Thermal Shift Assay

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mitogen-activated protein kinase 1

External ID: CHEMBL5066518

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL4040
ChEMBL Target Name: MAP kinase ERK2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Delta TM	=	-0.03532	C	Thermal Shift Assay
Delta TM	=	-0.09791	C	Thermal Shift Assay
Delta TM	=	-0.72	C
Delta TM	=	0.39	C	Thermal Shift Assay
Delta TM	=	0.6544	C	Thermal Shift Assay
Delta TM	=	0.01068	C	Thermal Shift Assay
Delta TM	=	0.05	C	Thermal Shift Assay
Delta TM	=	0.3911	C	Thermal Shift Assay
Delta TM	=	-0.1368	C	Thermal Shift Assay
Delta TM	=	0.38	C
Delta TM	=	0.18	C	Thermal Shift Assay
Delta TM	=	0.02	C	Thermal Shift Assay
Delta TM	=	0.24	C	Thermal Shift Assay
Delta TM	=	-0.1886	C	Thermal Shift Assay
Delta TM	=	-0.3286	C	Thermal Shift Assay
Delta TM	=	-0.9406	C	Thermal Shift Assay
Delta TM	=	-0.6238	C	Thermal Shift Assay
Delta TM	=	0.17	C	Thermal Shift Assay
Delta TM	=	0.35	C	Thermal Shift Assay
Delta TM	=	0.08	C	Thermal Shift Assay

2245237-53-8 靶点实验数据