HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL2161109

Protocol: N/A

Comment: Journal: ACS Med. Chem. Lett.
Year: 2012
Volume: 3
Issue: 10
First Page: 828
Last Page: 833
DOI: 10.1021/ml300192k

Standard Type	Standard Relation	Standard Value
FC	=	3.6
FC	=	24.1
FC	=	9.8
FC	=	13.4
FC	=	0.6
FC	=	2.3
FC	=	4.9

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3101119

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2014
Volume: 22
Issue: 1
First Page: 643
Last Page: 650
DOI: 10.1016/j.bmc.2013.10.024

Standard Type	Standard Relation	Standard Value	Activity Comment
Activity			Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL2161110

Protocol: N/A

Comment: Journal: ACS Med. Chem. Lett.
Year: 2012
Volume: 3
Issue: 10
First Page: 828
Last Page: 833
DOI: 10.1021/ml300192k

Standard Type	Standard Relation	Standard Value
Selectivity ratio	=	9
Selectivity ratio	=	7.1
Selectivity ratio	=	6.8
Selectivity ratio	=	2.6
Selectivity ratio	=	22.8
Selectivity ratio	=	17.8

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Oxysterols receptor LXR-beta

External ID: CHEMBL3101120

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2014
Volume: 22
Issue: 1
First Page: 643
Last Page: 650
DOI: 10.1016/j.bmc.2013.10.024

Target ChEMBL ID: CHEMBL3706564
ChEMBL Target Name: Liver X receptor
ChEMBL Target Type: PROTEIN FAMILY - Target is a group of closely related proteins
Relationship Type: D - Direct protein target assigned
Confidence: Multiple direct protein targets may be assigned

Standard Type	Activity Comment
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL2161108

Protocol: N/A

Comment: Journal: ACS Med. Chem. Lett.
Year: 2012
Volume: 3
Issue: 10
First Page: 828
Last Page: 833
DOI: 10.1021/ml300192k

Standard Type	Standard Relation	Standard Value
FC	=	32.4
FC	=	4.7
FC	=	69.9
FC	=	91.8
FC	=	1.6
FC	=	52.5
FC	=	87.1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Oxysterols receptor LXR-beta

External ID: CHEMBL3117438

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2014
Volume: 74
First Page: 258
Last Page: 263
DOI: 10.1016/j.ejmech.2014.01.003

Target ChEMBL ID: CHEMBL3706564
ChEMBL Target Name: Liver X receptor
ChEMBL Target Type: PROTEIN FAMILY - Target is a group of closely related proteins
Relationship Type: D - Direct protein target assigned
Confidence: Multiple direct protein targets may be assigned

Standard Type	Activity Comment
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Oxysterols receptor LXR-beta

External ID: CHEMBL3117655

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2014
Volume: 74
First Page: 258
Last Page: 263
DOI: 10.1016/j.ejmech.2014.01.003

Target ChEMBL ID: CHEMBL3706564
ChEMBL Target Name: Liver X receptor
ChEMBL Target Type: PROTEIN FAMILY - Target is a group of closely related proteins
Relationship Type: D - Direct protein target assigned
Confidence: Multiple direct protein targets may be assigned

Standard Type	Activity Comment
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Oxysterols receptor LXR-beta

External ID: CHEMBL3117659

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2014
Volume: 74
First Page: 258
Last Page: 263
DOI: 10.1016/j.ejmech.2014.01.003

Target ChEMBL ID: CHEMBL3706564
ChEMBL Target Name: Liver X receptor
ChEMBL Target Type: PROTEIN FAMILY - Target is a group of closely related proteins
Relationship Type: D - Direct protein target assigned
Confidence: Multiple direct protein targets may be assigned

Standard Type	Activity Comment
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Oxysterols receptor LXR-beta

External ID: CHEMBL3117660

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2014
Volume: 74
First Page: 258
Last Page: 263
DOI: 10.1016/j.ejmech.2014.01.003

Target ChEMBL ID: CHEMBL3706564
ChEMBL Target Name: Liver X receptor
ChEMBL Target Type: PROTEIN FAMILY - Target is a group of closely related proteins
Relationship Type: D - Direct protein target assigned
Confidence: Multiple direct protein targets may be assigned

Standard Type	Activity Comment
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Oxysterols receptor LXR-beta

External ID: CHEMBL3117661

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2014
Volume: 74
First Page: 258
Last Page: 263
DOI: 10.1016/j.ejmech.2014.01.003

Target ChEMBL ID: CHEMBL3706564
ChEMBL Target Name: Liver X receptor
ChEMBL Target Type: PROTEIN FAMILY - Target is a group of closely related proteins
Relationship Type: D - Direct protein target assigned
Confidence: Multiple direct protein targets may be assigned

Standard Type	Activity Comment
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NPC1-like intracellular cholesterol transporter 1

External ID: CHEMBL3362445

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2014
Volume: 24
Issue: 15
First Page: 3480
Last Page: 3485
DOI: 10.1016/j.bmcl.2014.05.064

Target ChEMBL ID: CHEMBL2027
ChEMBL Target Name: Niemann-Pick C1-like protein 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
	Activity				Dose-dependent effect
3.4	EC50	=	3400	nM
2.9	EC50	=	2900	nM
8.7	EC50	=	8700	nM
1.7	EC50	=	1700	nM
1.7	EC50	=	1700	nM
4.3	EC50	=	4300	nM
3.4	EC50	=	3400	nM
1.7	EC50	=	1700	nM
1.5	EC50	=	1500	nM
9.9	EC50	=	9900	nM
1.4	EC50	=	1400	nM
4.8	EC50	=	4800	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Oxysterols receptor LXR-beta

External ID: CHEMBL3117662

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2014
Volume: 74
First Page: 258
Last Page: 263
DOI: 10.1016/j.ejmech.2014.01.003

Target ChEMBL ID: CHEMBL3706564
ChEMBL Target Name: Liver X receptor
ChEMBL Target Type: PROTEIN FAMILY - Target is a group of closely related proteins
Relationship Type: D - Direct protein target assigned
Confidence: Multiple direct protein targets may be assigned

Standard Type	Activity Comment
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Oxysterols receptor LXR-beta

External ID: CHEMBL3118604

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2014
Volume: 74
First Page: 258
Last Page: 263
DOI: 10.1016/j.ejmech.2014.01.003

Target ChEMBL ID: CHEMBL3706564
ChEMBL Target Name: Liver X receptor
ChEMBL Target Type: PROTEIN FAMILY - Target is a group of closely related proteins
Relationship Type: D - Direct protein target assigned
Confidence: Multiple direct protein targets may be assigned

Standard Type	Activity Comment
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Oxysterols receptor LXR-beta

External ID: CHEMBL3118605

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2014
Volume: 74
First Page: 258
Last Page: 263
DOI: 10.1016/j.ejmech.2014.01.003

Target ChEMBL ID: CHEMBL3706564
ChEMBL Target Name: Liver X receptor
ChEMBL Target Type: PROTEIN FAMILY - Target is a group of closely related proteins
Relationship Type: D - Direct protein target assigned
Confidence: Multiple direct protein targets may be assigned

Standard Type	Activity Comment
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Oxysterols receptor LXR-beta

External ID: CHEMBL3118606

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2014
Volume: 74
First Page: 258
Last Page: 263
DOI: 10.1016/j.ejmech.2014.01.003

Target ChEMBL ID: CHEMBL3706564
ChEMBL Target Name: Liver X receptor
ChEMBL Target Type: PROTEIN FAMILY - Target is a group of closely related proteins
Relationship Type: D - Direct protein target assigned
Confidence: Multiple direct protein targets may be assigned

Standard Type	Activity Comment
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Oxysterols receptor LXR-beta

External ID: CHEMBL3118807

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2014
Volume: 74
First Page: 258
Last Page: 263
DOI: 10.1016/j.ejmech.2014.01.003

Target ChEMBL ID: CHEMBL3706564
ChEMBL Target Name: Liver X receptor
ChEMBL Target Type: PROTEIN FAMILY - Target is a group of closely related proteins
Relationship Type: D - Direct protein target assigned
Confidence: Multiple direct protein targets may be assigned

Standard Type	Activity Comment
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Oxysterols receptor LXR-alpha

External ID: CHEMBL712592

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2001
Volume: 44
Issue: 6
First Page: 886
Last Page: 897
DOI: 10.1021/jm0004749

Target ChEMBL ID: CHEMBL2808
ChEMBL Target Name: LXR-alpha
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Relation	Standard Value
RE	<	0.1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL2423071

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2013
Volume: 21
Issue: 17
First Page: 5297
Last Page: 5309
DOI: 10.1016/j.bmc.2013.06.022

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Oxysterol-binding protein 1

External ID: CHEMBL5320826

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2023
Volume: 66
Issue: 6
First Page: 3866
Last Page: 3875
DOI: 10.1021/acs.jmedchem.2c01025

Target ChEMBL ID: CHEMBL4523203
ChEMBL Target Name: Oxysterol-binding protein 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.12	Ki	=	120	nM
0.068	Ki	=	68	nM
0.13	Ki	=	130	nM
100	Ki	>	100000	nM
50	Ki	>	50000	nM
30	Ki	>	30000	nM
10	Ki	>	10000	nM
100	Ki	>	100000	nM
0.078	Ki	=	78	nM
10	Ki	>	10000	nM
0.12	Ki	=	120	nM
20	Ki	>	20000	nM
50	Ki	>	50000	nM
100	Ki	>	100000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Oxysterol-binding protein 2

External ID: CHEMBL5320827

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2023
Volume: 66
Issue: 6
First Page: 3866
Last Page: 3875
DOI: 10.1021/acs.jmedchem.2c01025

Target ChEMBL ID: CHEMBL5465343
ChEMBL Target Name: Oxysterol-binding protein 2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.32	Ki	=	320	nM
50	Ki	>	50000	nM
30	Ki	>	30000	nM
15	Ki	>	15000	nM
3	Ki	>	3000	nM
0.092	Ki	=	92	nM
20	Ki	>	20000	nM
0.87	Ki	>	870	nM
30	Ki	>	30000	nM
50	Ki	>	50000	nM
100	Ki	>	100000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3101118

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2014
Volume: 22
Issue: 1
First Page: 643
Last Page: 650
DOI: 10.1016/j.bmc.2013.10.024

Standard Type	Standard Units	Activity Comment
Inhibition	%	Active

22348-64-7 靶点实验数据