前往化源商城

2227-79-4 靶点实验数据

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:N/A
External ID: CHEMBL4191701
Protocol: N/A
Comment: Journal: Eur J Med Chem
Year: 2017
Volume: 138
First Page: 51
Last Page: 65
DOI: 10.1016/j.ejmech.2017.06.012
Standard TypeStandard RelationStandard ValueStandard Units
T1/2=0.065hr
T1/2=0.015hr
T1/2=0.2233hr
T1/2=0.03hr
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:N/A
External ID: CHEMBL4191702
Protocol: N/A
Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur J Med Chem
Year: 2017
Volume: 138
First Page: 51
Last Page: 65
DOI: 10.1016/j.ejmech.2017.06.012
PubChem Standard ValueStandard TypeStandard RelationStandard ValueStandard Units
20.9Cmax=20900nM
13.8Cmax=13800nM
23.5Cmax=23500nM
11.3Cmax=11300nM
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Tyrosinase
External ID: CHEMBL3743604
Protocol: N/A
Comment: Journal: Eur. J. Med. Chem.
Year: 2015
Volume: 106
First Page: 157
Last Page: 166
DOI: 10.1016/j.ejmech.2015.10.033

Target ChEMBL ID: CHEMBL5346
ChEMBL Target Name: Tyrosinase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned
Standard TypeStandard RelationStandard ValueStandard Units
Inhibition=104%
Inhibition=105%
Inhibition=107%
Inhibition=63%
Inhibition=105%
Inhibition=106%
Inhibition=91%
Inhibition=109%
Inhibition=103%
Inhibition=98%
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:N/A
External ID: CHEMBL3743603
Protocol: N/A
Comment: Journal: Eur. J. Med. Chem.
Year: 2015
Volume: 106
First Page: 157
Last Page: 166
DOI: 10.1016/j.ejmech.2015.10.033
Standard TypeStandard RelationStandard ValueStandard Units
Survival=103%
Survival=116%
Survival=106%
Survival=106%
Survival=121%
Survival=110%
Survival=116%
Survival=108%
Survival=117%
Survival=105%
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Polyphenol oxidase 2
External ID: CHEMBL3743602
Protocol: N/A
Comment: Journal: Eur. J. Med. Chem.
Year: 2015
Volume: 106
First Page: 157
Last Page: 166
DOI: 10.1016/j.ejmech.2015.10.033

Target ChEMBL ID: CHEMBL3318
ChEMBL Target Name: Tyrosinase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned
Standard TypeStandard RelationStandard ValueStandard Units
KSV=1.710'3/M
KSV=110'3/M
KSV=9.510'3/M
KSV=2.410'3/M
KSV=10.210'3/M
KSV=7.510'3/M
KSV=8.310'3/M
KSV=8.510'3/M
KSV=9.210'3/M
KSV=910'3/M
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Tyrosinase
External ID: CHEMBL3743607
Protocol: N/A
Comment: Journal: Eur. J. Med. Chem.
Year: 2015
Volume: 106
First Page: 157
Last Page: 166
DOI: 10.1016/j.ejmech.2015.10.033

Target ChEMBL ID: CHEMBL5346
ChEMBL Target Name: Tyrosinase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned
Standard TypeStandard RelationStandard ValueStandard Units
Inhibition=97%
Inhibition=99%
Inhibition=88%
Inhibition=27%
Inhibition=84%
Inhibition=93%
Inhibition=42%
Inhibition=83%
Inhibition=72%
Inhibition=78%
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Tyrosinase
External ID: CHEMBL3743606
Protocol: N/A
Comment: Journal: Eur. J. Med. Chem.
Year: 2015
Volume: 106
First Page: 157
Last Page: 166
DOI: 10.1016/j.ejmech.2015.10.033

Target ChEMBL ID: CHEMBL5346
ChEMBL Target Name: Tyrosinase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned
Standard TypeStandard RelationStandard ValueStandard Units
Inhibition=102%
Inhibition=102%
Inhibition=104%
Inhibition=54%
Inhibition=100%
Inhibition=104%
Inhibition=57%
Inhibition=106%
Inhibition=63%
Inhibition=56%
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:N/A
External ID: CHEMBL5350603
Protocol: N/A
Comment: Journal: J Med Chem
Year: 2023
Volume: 66
Issue: 14
First Page: 9607
Last Page: 9621
DOI: 10.1021/acs.jmedchem.3c00321
Standard TypeStandard Text Value
Drug metabolismMetabolite_Notdetected
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Tyrosinase
External ID: CHEMBL3743605
Protocol: N/A
Comment: Journal: Eur. J. Med. Chem.
Year: 2015
Volume: 106
First Page: 157
Last Page: 166
DOI: 10.1016/j.ejmech.2015.10.033

Target ChEMBL ID: CHEMBL5346
ChEMBL Target Name: Tyrosinase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned
Standard TypeStandard RelationStandard ValueStandard Units
Inhibition=100%
Inhibition=103%
Inhibition=104%
Inhibition=55%
Inhibition=103%
Inhibition=103%
Inhibition=75%
Inhibition=104%
Inhibition=93%
Inhibition=80%
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Mus musculus
External ID: CHEMBL5350618
Protocol: N/A
Comment: Journal: J Med Chem
Year: 2023
Volume: 66
Issue: 14
First Page: 9607
Last Page: 9621
DOI: 10.1021/acs.jmedchem.3c00321

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular
Standard TypeStandard UnitsActivity Comment
Inhibition%Active