HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL850375

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1994
Volume: 37
Issue: 17
First Page: 2686
Last Page: 2696
DOI: 10.1021/jm00043a008

Standard Type	Standard Relation	Standard Value
Ratio	=	4.2
Ratio	=	4.1
Ratio	=	3.8
Ratio	=	63
Ratio	=	0.03
Ratio	=	0.51

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL850374

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1994
Volume: 37
Issue: 17
First Page: 2686
Last Page: 2696
DOI: 10.1021/jm00043a008

Standard Type	Standard Relation	Standard Value
Ratio	=	28
Ratio	=	6.7
Ratio	=	14
Ratio	=	64
Ratio	=	0.8
Ratio	=	5
Ratio	=	2

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Dopamine receptors; D2 & D4

External ID: CHEMBL850373

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1994
Volume: 37
Issue: 17
First Page: 2686
Last Page: 2696
DOI: 10.1021/jm00043a008

Target ChEMBL ID: CHEMBL2095396
ChEMBL Target Name: Dopamine receptors; D2 & D4
ChEMBL Target Type: SELECTIVITY GROUP - Target is a pair of proteins for which the selectivity has been assessed
Relationship Type: H - Homologous protein target assigned
Confidence: Multiple homologous protein targets may be assigned

Standard Type	Standard Relation	Standard Value
Ratio	=	10
Ratio	=	2.9
Ratio	=	6.5
Ratio	=	4.3
Ratio	=	6
Ratio	=	4.6
Ratio	=	11
Ratio	=	7.8

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：D(4) dopamine receptor

External ID: CHEMBL674500

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1995
Volume: 38
Issue: 4
First Page: 708
Last Page: 714
DOI: 10.1021/jm00004a016

Target ChEMBL ID: CHEMBL219
ChEMBL Target Name: Dopamine D4 receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
5.4E-4	Ki	=	0.54	nM
0.002	Ki	=	2	nM
0.012	Ki	=	12	nM
0.27	Ki	=	270	nM
0.1	Ki	=	100	nM
0.029	Ki	=	29	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：5-hydroxytryptamine receptor 2A

External ID: CHEMBL617478

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1994
Volume: 37
Issue: 17
First Page: 2686
Last Page: 2696
DOI: 10.1021/jm00043a008

Target ChEMBL ID: CHEMBL322
ChEMBL Target Name: Serotonin 2a (5-HT2a) receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.003	Ki	=	3	nM
0.011	Ki	=	11	nM
0.25	Ki	=	250	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：D(2) dopamine receptor

External ID: CHEMBL675960

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1994
Volume: 37
Issue: 17
First Page: 2686
Last Page: 2696
DOI: 10.1021/jm00043a008

Target ChEMBL ID: CHEMBL217
ChEMBL Target Name: Dopamine D2 receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.0025	Ki	=	2.5	nM
0.021	Ki	=	21	nM
0.057	Ki	=	57	nM
0.29	Ki	=	290	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：D(2) dopamine receptor

External ID: CHEMBL672525

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1995
Volume: 38
Issue: 4
First Page: 708
Last Page: 714
DOI: 10.1021/jm00004a016

Target ChEMBL ID: CHEMBL217
ChEMBL Target Name: Dopamine D2 receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.0025	Ki	=	2.5	nM
0.021	Ki	=	21	nM
0.57	Ki	=	570	nM
0.44	Ki	=	440	nM
0.23	Ki	=	230	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：D(4) dopamine receptor

External ID: CHEMBL673252

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1994
Volume: 37
Issue: 17
First Page: 2686
Last Page: 2696
DOI: 10.1021/jm00043a008

Target ChEMBL ID: CHEMBL219
ChEMBL Target Name: Dopamine D4 receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
5.4E-4	Ki	=	0.54	nM
0.002	Ki	=	2	nM
0.047	Ki	=	47	nM
2.7	Ki	=	2700	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：5-hydroxytryptamine receptor 2C

External ID: CHEMBL617843

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1995
Volume: 38
Issue: 4
First Page: 708
Last Page: 714
DOI: 10.1021/jm00004a016

Target ChEMBL ID: CHEMBL324
ChEMBL Target Name: Serotonin 2c (5-HT2c) receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.02	Ki	=	20	nM
0.051	Ki	=	51	nM
0.014	Ki	=	14	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：5-hydroxytryptamine receptor 2C

External ID: CHEMBL617846

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1994
Volume: 37
Issue: 17
First Page: 2686
Last Page: 2696
DOI: 10.1021/jm00043a008

Target ChEMBL ID: CHEMBL324
ChEMBL Target Name: Serotonin 2c (5-HT2c) receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.006	Ki	=	6	nM
0.018	Ki	=	18	nM
0.39	Ki	=	390	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：5-hydroxytryptamine receptor 3B

External ID: CHEMBL618922

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1994
Volume: 37
Issue: 17
First Page: 2686
Last Page: 2696
DOI: 10.1021/jm00043a008

Target ChEMBL ID: CHEMBL2094116
ChEMBL Target Name: Serotonin 3 (5-HT3) receptor
ChEMBL Target Type: PROTEIN COMPLEX - Target is a defined protein complex, consisting of multiple subunits
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous protein complex subunits assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.057	Ki	=	57	nM
0.031	Ki	=	31	nM
0.081	Ki	=	81	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL848453

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1995
Volume: 38
Issue: 4
First Page: 708
Last Page: 714
DOI: 10.1021/jm00004a016

Standard Type	Standard Relation	Standard Value
Ratio	=	28
Ratio	=	8.8
Ratio	=	0.8
Ratio	=	5

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Dopamine receptors; D2 & D4

External ID: CHEMBL884964

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1995
Volume: 38
Issue: 4
First Page: 708
Last Page: 714
DOI: 10.1021/jm00004a016

Target ChEMBL ID: CHEMBL2095396
ChEMBL Target Name: Dopamine receptors; D2 & D4
ChEMBL Target Type: SELECTIVITY GROUP - Target is a pair of proteins for which the selectivity has been assessed
Relationship Type: H - Homologous protein target assigned
Confidence: Multiple homologous protein targets may be assigned

Standard Type	Standard Relation	Standard Value
Ratio	=	10
Ratio	=	0.2
Ratio	=	4.3
Ratio	=	4.6
Ratio	=	11

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：5-hydroxytryptamine receptor 2A

External ID: CHEMBL617472

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1995
Volume: 38
Issue: 4
First Page: 708
Last Page: 714
DOI: 10.1021/jm00004a016

Target ChEMBL ID: CHEMBL322
ChEMBL Target Name: Serotonin 2a (5-HT2a) receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.006	Ki	=	6	nM
0.022	Ki	=	22	nM
0.006	Ki	=	6	nM

22012-06-2 靶点实验数据