HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Plasmodium falciparum

External ID: CHEMBL765487

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2000
Volume: 43
Issue: 2
First Page: 283
Last Page: 291
DOI: 10.1021/jm990437l

Target ChEMBL ID: CHEMBL364
ChEMBL Target Name: Plasmodium falciparum
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
3.8	IC50	=	3800	nM
10	IC50	>	10000	nM
10	IC50	>	10000	nM
10	IC50	>	10000	nM
10	IC50	>	10000	nM
10	IC50	>	10000	nM
10	IC50	>	10000	nM
10	IC50	>	10000	nM
10	IC50	>	10000	nM
10	IC50	>	10000	nM
10	IC50	>	10000	nM
4.7	IC50	=	4700	nM
10	IC50	>	10000	nM
4	IC50	=	4000	nM
10	IC50	>	10000	nM
0.0809	IC50	=	80.9	nM
0.049	IC50	=	49	nM
0.092	IC50	=	92	nM
0.799	IC50	=	799	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Major prion protein

External ID: CHEMBL1291749

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2010
Volume: 45
Issue: 11
First Page: 5468
Last Page: 5473
DOI: 10.1016/j.ejmech.2010.07.054

Target ChEMBL ID: CHEMBL1293203
ChEMBL Target Name: Major prion protein
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	Active
Activity	Active
Activity	Active
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Ferriprotoporphyrin IX

External ID: CHEMBL821353

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2000
Volume: 43
Issue: 2
First Page: 283
Last Page: 291
DOI: 10.1021/jm990437l

Target ChEMBL ID: CHEMBL613897
ChEMBL Target Name: Ferriprotoporphyrin IX
ChEMBL Target Type: SMALL MOLECULE - Target is a small molecule such as an amino acid, sugar or metabolite)
Relationship Type: M - Molecular target other than protein assigned
Confidence: Target assigned is molecular non-protein target

Standard Type	Standard Relation	Standard Value
Log K	=	5.52
Log K	<	2.5
Log K	=	4.66
Log K	=	4.43
Log K	=	4.49
Log K	=	4.23
Log K	<	2.5
Log K	=	4.28
Log K	=	4.18
Log K	<	2.5
Log K	=	4.38
Log K	<	2.5
Log K	<	2.5
Log K	<	2.5
Log K	=	4.59
Log K	=	4.34
Log K	=	4.48
Log K	=	4.26
Log K	=	4.96
Log K	=	5.81

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Major prion protein

External ID: CHEMBL1291422

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2010
Volume: 45
Issue: 11
First Page: 5468
Last Page: 5473
DOI: 10.1016/j.ejmech.2010.07.054

Target ChEMBL ID: CHEMBL1293203
ChEMBL Target Name: Major prion protein
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	97	%
Inhibition	=	8.4	%
Inhibition	=	38.6	%
Inhibition	=	82	%
Inhibition	=	7.9	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mycobacterium tuberculosis

External ID: CHEMBL1031572

Protocol: N/A

Comment: Journal: Bioorg Med Chem
Year: 2009
Volume: 17
Issue: 4
First Page: 1474
Last Page: 1480
DOI: 10.1016/j.bmc.2009.01.013

Target ChEMBL ID: CHEMBL360
ChEMBL Target Name: Mycobacterium tuberculosis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	50	ug.mL-1
MIC	>	100	ug.mL-1
MIC	=	25	ug.mL-1
MIC	>	100	ug.mL-1
MIC	>	100	ug.mL-1
MIC	>	100	ug.mL-1
MIC	=	100	ug.mL-1
MIC	>	100	ug.mL-1
MIC	=	100	ug.mL-1
MIC	>	100	ug.mL-1
MIC	>	100	ug.mL-1
MIC	=	100	ug.mL-1
MIC	>	100	ug.mL-1
MIC	=	100	ug.mL-1
MIC	>	100	ug.mL-1
MIC	=	50	ug.mL-1
MIC	>	100	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Histidine-rich protein PFHRP-II

External ID: CHEMBL846835

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2000
Volume: 43
Issue: 2
First Page: 283
Last Page: 291
DOI: 10.1021/jm990437l

Target ChEMBL ID: CHEMBL1923
ChEMBL Target Name: Histidine-rich protein
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Units	Activity Comment
Inhibition	%	Active
Inhibition	%
Inhibition	%
Inhibition	%
Inhibition	%
Inhibition	%
Inhibition	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Ferriprotoporphyrin IX

External ID: CHEMBL2394758

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2013
Volume: 21
Issue: 13
First Page: 3738
Last Page: 3748
DOI: 10.1016/j.bmc.2013.04.040

Target ChEMBL ID: CHEMBL613897
ChEMBL Target Name: Ferriprotoporphyrin IX
ChEMBL Target Type: SMALL MOLECULE - Target is a small molecule such as an amino acid, sugar or metabolite)
Relationship Type: M - Molecular target other than protein assigned
Confidence: Target assigned is molecular non-protein target

Standard Type	Standard Relation	Standard Value
log K	=	5.01
log K	=	3.83
log K	=	3.92
log K	=	4.38
log K	=	4.62
log K	=	5.81
log K	=	5.1
log K	=	4.24
log K	=	4.17
log K	=	4.41
log K	=	3.44
log K	=	3.76
log K	=	4.7
log K	=	4.57
log K	=	4.32

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Major prion protein

External ID: CHEMBL1291425

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur. J. Med. Chem.
Year: 2010
Volume: 45
Issue: 11
First Page: 5468
Last Page: 5473
DOI: 10.1016/j.ejmech.2010.07.054

Target ChEMBL ID: CHEMBL1293203
ChEMBL Target Name: Major prion protein
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
1	C50	>	1	uM
0.1	C50	=	0.1	uM
1	C50	>	1	uM
1	C50	>	1	uM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL2394757

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2013
Volume: 21
Issue: 13
First Page: 3738
Last Page: 3748
DOI: 10.1016/j.bmc.2013.04.040

Standard Type	Standard Relation	Standard Value	Standard Units
IA50	=	5.8	equiv
IA50	=	10	equiv
IA50	=	14.9	equiv
IA50	=	10.6	equiv
IA50	=	5.7	equiv
IA50	=	2.2	equiv
IA50	=	5.4	equiv
IA50	=	15.6	equiv
IA50	=	10.8	equiv
IA50	=	5.6	equiv
IA50	>	20	equiv
IA50	=	10.3	equiv
IA50	=	5.4	equiv
IA50	=	5.7	equiv
IA50	=	6.1	equiv

21875-67-2 靶点实验数据