HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Adenosine receptor A1

External ID: CHEMBL898450

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2007
Volume: 15
Issue: 16
First Page: 5440
Last Page: 5447
DOI: 10.1016/j.bmc.2007.05.056

Target ChEMBL ID: CHEMBL226
ChEMBL Target Name: Adenosine A1 receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
	IC50				Not Determined
	IC50				Not Determined

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Adenosine receptor A3

External ID: CHEMBL898446

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2007
Volume: 15
Issue: 16
First Page: 5440
Last Page: 5447
DOI: 10.1016/j.bmc.2007.05.056

Target ChEMBL ID: CHEMBL256
ChEMBL Target Name: Adenosine A3 receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
100	EC50	>	100000	nM
100	EC50	>	100000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Adenosine receptor A3

External ID: CHEMBL637929

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1995
Volume: 38
Issue: 7
First Page: 1174
Last Page: 1188
DOI: 10.1021/jm00007a014

Target ChEMBL ID: CHEMBL3360
ChEMBL Target Name: Adenosine A3 receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Displacement	=	10	%
Displacement	=	39	%
Displacement	=	43	%
Displacement	=	24	%
Displacement	=	68	%
Displacement	=	26	%
Displacement	=	9	%
Displacement	=	28	%
Displacement	=	31	%
Displacement	=	31	%
Displacement	=	21	%
Displacement	=	11	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Adenosine receptor A2a

External ID: CHEMBL641955

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1995
Volume: 38
Issue: 7
First Page: 1174
Last Page: 1188
DOI: 10.1021/jm00007a014

Target ChEMBL ID: CHEMBL302
ChEMBL Target Name: Adenosine A2a receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Displacement	=	25	%
Displacement	=	48	%
Displacement	=	0	%
Displacement	=	49	%
Displacement	=	26	%
Displacement	=	13	%
Displacement	=	39	%
Displacement	=	35	%
Displacement	=	8	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Adenosine receptor A3

External ID: CHEMBL898448

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2007
Volume: 15
Issue: 16
First Page: 5440
Last Page: 5447
DOI: 10.1016/j.bmc.2007.05.056

Target ChEMBL ID: CHEMBL256
ChEMBL Target Name: Adenosine A3 receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
100	IC50	>	100000	nM
0.15	IC50	=	150	nM
	Imax	=	100	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Adenosine receptor A1

External ID: CHEMBL898449

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2007
Volume: 15
Issue: 16
First Page: 5440
Last Page: 5447
DOI: 10.1016/j.bmc.2007.05.056

Target ChEMBL ID: CHEMBL226
ChEMBL Target Name: Adenosine A1 receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
	EC50				Not Determined
	EC50				Not Determined

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：RNA-directed RNA polymerase

External ID: CHEMBL691888

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2004
Volume: 47
Issue: 9
First Page: 2283
Last Page: 2295
DOI: 10.1021/jm030424e

Target ChEMBL ID: CHEMBL4296320
ChEMBL Target Name: RNA-directed RNA polymerase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
50	EC50	=	50000	nM
50	EC50	>	50000	nM
1.2	EC50	=	1200	nM
7	EC50	=	7000	nM
50	EC50	>	50000	nM
50	EC50	>	50000	nM
50	EC50	>	50000	nM
50	EC50	>	50000	nM
50	EC50	>	50000	nM
3.5	EC50		3500	nM
50	EC50	>	50000	nM
50	EC50	>	50000	nM
50	EC50	>	50000	nM
50	EC50	>	50000	nM
50	EC50	>	50000	nM
50	EC50	>	50000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：RNA-directed RNA polymerase

External ID: CHEMBL691889

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2004
Volume: 47
Issue: 9
First Page: 2283
Last Page: 2295
DOI: 10.1021/jm030424e

Target ChEMBL ID: CHEMBL4296320
ChEMBL Target Name: RNA-directed RNA polymerase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.6	IC50	=	600	nM
47	IC50	=	47000	nM
28	IC50	=	28000	nM
2.6	IC50	=	2600	nM
50	IC50	>	50000	nM
46	IC50	=	46000	nM
4	IC50	=	4000	nM
50	IC50	>	50000	nM
0.13	IC50	=	130	nM
1.9	IC50	=	1900	nM
50	IC50	=	50000	nM
50	IC50	>	50000	nM
20	IC50	=	20000	nM
50	IC50	>	50000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Adenosine receptor A1

External ID: CHEMBL839891

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1995
Volume: 38
Issue: 7
First Page: 1174
Last Page: 1188
DOI: 10.1021/jm00007a014

Target ChEMBL ID: CHEMBL318
ChEMBL Target Name: Adenosine A1 receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Displacement	=	3	%
Displacement	=	29	%
Displacement	=	20	%
Displacement	=	53	%
Displacement	=	31	%
Displacement	=	41	%
Displacement	=	0	%

2140-79-6 靶点实验数据