HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Choline trimethylamine-lyase

External ID: CHEMBL4716054

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: RSC Med Chem
Year: 2020
Volume: 11
Issue: 12.0
First Page: 1402
Last Page: 1412
DOI: 10.1039/d0md00218f

Target ChEMBL ID: CHEMBL4739856
ChEMBL Target Name: Choline trimethylamine-lyase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
199	IC50	=	199000	nM	Outside typical range
212	IC50	=	212000	nM	Outside typical range
500	IC50	>	500000	nM	Outside typical range
301	IC50	=	301000	nM	Outside typical range
500	IC50	>	500000	nM	Outside typical range
500	IC50	>	500000	nM	Outside typical range
210	IC50	=	210000	nM	Outside typical range
2.4	IC50	=	2400	nM
500	IC50	>	500000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4716053

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: RSC Med Chem
Year: 2020
Volume: 11
Issue: 12.0
First Page: 1402
Last Page: 1412
DOI: 10.1039/d0md00218f

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
354	EC50	=	354000	nM	Outside typical range
409	EC50	=	409000	nM	Outside typical range
1000	EC50	>	1000000	nM	Outside typical range
488	EC50	=	488000	nM	Outside typical range
1000	EC50	>	1000000	nM	Outside typical range
1000	EC50	>	1000000	nM	Outside typical range
376	EC50	=	376000	nM	Outside typical range
5.4	EC50	=	5400	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4716062

Protocol: N/A

Comment: Journal: RSC Med Chem
Year: 2020
Volume: 11
Issue: 12.0
First Page: 1402
Last Page: 1412
DOI: 10.1039/d0md00218f

Standard Type	Standard Relation	Standard Value	Standard Units
Stability	>	90	%
Stability	>	90	%
Stability	>	90	%
Stability	>	90	%
Stability	>	90	%
Stability	>	90	%
Stability	>	90	%
Stability	>	90	%
Stability	>	90	%
Stability	>	90	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Purine nucleoside phosphorylase

External ID: CHEMBL3253154

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1978
Volume: 21
Issue: 9
First Page: 877
Last Page: 882
DOI: 10.1021/jm00207a008

Target ChEMBL ID: CHEMBL4338
ChEMBL Target Name: Purine nucleoside phosphorylase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	0	%
Activity	=	4	%
Activity	=	65	%
Activity	=	100	%
Activity	=	0	%
Activity	=	100	%
Activity	=	10	%
Activity	=	93	%
Activity	=	0	%
Activity	=	0	%
Activity	=	12	%

2140-65-0 靶点实验数据