HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：L-lactate dehydrogenase A chain

External ID: CHEMBL2060671

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2012
Volume: 55
Issue: 7
First Page: 3285
Last Page: 3306
DOI: 10.1021/jm201734r

Target ChEMBL ID: CHEMBL4835
ChEMBL Target Name: L-lactate dehydrogenase A chain
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
500	IC50	>	500000	nM
500	IC50	>	500000	nM
500	IC50	>	500000	nM
450	IC50	=	450000	nM
500	IC50	>	500000	nM
500	IC50	>	500000	nM
500	IC50	>	500000	nM
29.5	IC50	=	29500	nM
500	IC50	>	500000	nM
500	IC50	>	500000	nM
7.4	IC50	=	7400	nM
86.2	IC50	=	86200	nM
0.5	IC50	=	500	nM
500	IC50	>	500000	nM
500	IC50	>	500000	nM
500	IC50	>	500000	nM
4.2	IC50	=	4200	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：L-lactate dehydrogenase B chain

External ID: CHEMBL2060672

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2012
Volume: 55
Issue: 7
First Page: 3285
Last Page: 3306
DOI: 10.1021/jm201734r

Target ChEMBL ID: CHEMBL4940
ChEMBL Target Name: L-lactate dehydrogenase B chain
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
7.8	IC50	=	7800	nM
	IC50				Not Determined
	IC50				Not Determined
9.4	IC50	=	9400	nM
	IC50				Not Determined

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：L-lactate dehydrogenase A chain

External ID: CHEMBL1692976

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2011
Volume: 54
Issue: 6
First Page: 1599
Last Page: 1612
DOI: 10.1021/jm101007q

Target ChEMBL ID: CHEMBL4835
ChEMBL Target Name: L-lactate dehydrogenase A chain
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
10	IC50	=	10000	nM
	Inhibition	=	84	%
	Inhibition	=	99	%
	Inhibition	=	87	%
	Inhibition				Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1912878

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2011
Volume: 46
Issue: 11
First Page: 5398
Last Page: 5407
DOI: 10.1016/j.ejmech.2011.08.046

Standard Type	Standard Relation	Standard Value
Selectivity ratio	>	10

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：L-lactate dehydrogenase A chain

External ID: CHEMBL3768756

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2016
Volume: 59
Issue: 2
First Page: 487
Last Page: 496
DOI: 10.1021/acs.jmedchem.5b00168

Target ChEMBL ID: CHEMBL4835
ChEMBL Target Name: L-lactate dehydrogenase A chain
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
9.1	Ki	=	9100	nM
3	Ki	=	3000	nM
2.5	Ki	=	2500	nM
0.5	Ki	=	500	nM
2	Ki	=	2000	nM
130.6	IC50	=	130600	nM	Outside typical range
0.0026	IC50	=	2.6	nM
0.016	IC50	=	16	nM
1.3	Ki	=	1300	nM
0.2	Ki	=	200	nM
0.03	Ki	=	30	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：BindingDB 靶标：N/A

External ID: BindingDB_5399_3

Protocol: N/A

Comment: Compounds with any of Ki, IC50, Kd, or EC50 activity value <= 10uM are labeled as "Active".
If multiple measurements are available for a given compound, it is labeled as "Active" if any of the measurements meet the criterion. Activity values are checked in the order of Ki, IC50, Kd, and EC50. The first entry that meets the above activity threshold is used to determine "Standard Type", "Standard Relation", and "PubChem Standard Value". Otherwise, the first non-empty entry will be used to set those values.

Standard Type	Standard Relation	PubChem Standard Value	IC50 Qualifier	IC50	Target Accession(s)	Ligand	Target
IC50	>	500	>	500000	P04642	BDBM50078827	L-lactate dehydrogenase A chain
IC50	>	500	>	500000	P00338	BDBM50192453	L-lactate dehydrogenase A chain
IC50	>	500	>	500000	P00338	BDBM50219487	L-lactate dehydrogenase A chain
IC50	>	500	>	500000	P00338	BDBM50339607	L-lactate dehydrogenase A chain
IC50		132		132000	P00338	BDBM86114	L-lactate dehydrogenase A chain
IC50		9.4		9400	P07195	BDBM86114	L-lactate dehydrogenase B chain
IC50	>	500	>	500000	P04642	BDBM86118	L-lactate dehydrogenase A chain
IC50	>	500	>	500000	P04642	BDBM86119	L-lactate dehydrogenase A chain
IC50	>	500	>	500000	P04642	BDBM86120	L-lactate dehydrogenase A chain
IC50	>	500	>	500000	P04642	BDBM86121	L-lactate dehydrogenase A chain
IC50	>	500	>	500000	P04642	BDBM86122	L-lactate dehydrogenase A chain
IC50	>	500	>	500000	P04642	BDBM86123	L-lactate dehydrogenase A chain
IC50		86.2		86200	P04642	BDBM86132	L-lactate dehydrogenase A chain

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3301363

Protocol: N/A

Comment: Data Source: AstraZeneca DMPK/physicochemical

Standard Type	Standard Value
LogD7.4	1.56
LogD7.4	1.39
LogD7.4	-0.78
LogD7.4	2.22
LogD7.4	3
LogD7.4	1.91
LogD7.4	-0.84
LogD7.4	1.19
LogD7.4	-1.08
LogD7.4	3.08
LogD7.4	3.65
LogD7.4	-0.5
LogD7.4	2.43
LogD7.4	2.3
LogD7.4	3.65
LogD7.4	4.3
LogD7.4	3.26
LogD7.4	2.55
LogD7.4	1.69
LogD7.4	1.46

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3301364

Protocol: N/A

Comment: Data Source: AstraZeneca DMPK/physicochemical

PubChem Standard Value	Standard Type	Standard Value	Standard Units
0.2	Solubility	200	nM
0.1	Solubility	100	nM
79.4	Solubility	79400	nM
741.3	Solubility	741300	nM
1445.4	Solubility	1445400	nM
151.4	Solubility	151400	nM
245.5	Solubility	245500	nM
239.9	Solubility	239900	nM
1445.4	Solubility	1445400	nM
1445.4	Solubility	1445400	nM
50.1	Solubility	50100	nM
154.9	Solubility	154900	nM
144.5	Solubility	144500	nM
10.5	Solubility	10500	nM
426.6	Solubility	426600	nM
407.4	Solubility	407400	nM
457.1	Solubility	457100	nM
9.1	Solubility	9100	nM
2.1	Solubility	2100	nM
158.5	Solubility	158500	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：L-lactate dehydrogenase B chain

External ID: CHEMBL3768757

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2016
Volume: 59
Issue: 2
First Page: 487
Last Page: 496
DOI: 10.1021/acs.jmedchem.5b00168

Target ChEMBL ID: CHEMBL4940
ChEMBL Target Name: L-lactate dehydrogenase B chain
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
39	Ki	=	39000	nM
92	Ki	=	92000	nM
92	Ki	=	92000	nM
39	Ki	=	39000	nM
78	Ki	=	78000	nM
0.043	IC50	=	43	nM
8	Ki	=	8000	nM
0.7	Ki	=	700	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5228990

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem
Year: 2021
Volume: 50
First Page: 116458
Last Page: 116458
DOI: 10.1016/j.bmc.2021.116458

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
1.75	IC50	=	1750	nM

213971-34-7 靶点实验数据