HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：L-lactate dehydrogenase A chain

External ID: CHEMBL3768756

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2016
Volume: 59
Issue: 2
First Page: 487
Last Page: 496
DOI: 10.1021/acs.jmedchem.5b00168

Target ChEMBL ID: CHEMBL4835
ChEMBL Target Name: L-lactate dehydrogenase A chain
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
9.1	Ki	=	9100	nM
3	Ki	=	3000	nM
2.5	Ki	=	2500	nM
0.5	Ki	=	500	nM
2	Ki	=	2000	nM
130.6	IC50	=	130600	nM	Outside typical range
0.0026	IC50	=	2.6	nM
0.016	IC50	=	16	nM
1.3	Ki	=	1300	nM
0.2	Ki	=	200	nM
0.03	Ki	=	30	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：L-lactate dehydrogenase B chain

External ID: CHEMBL3768757

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2016
Volume: 59
Issue: 2
First Page: 487
Last Page: 496
DOI: 10.1021/acs.jmedchem.5b00168

Target ChEMBL ID: CHEMBL4940
ChEMBL Target Name: L-lactate dehydrogenase B chain
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
39	Ki	=	39000	nM
92	Ki	=	92000	nM
92	Ki	=	92000	nM
39	Ki	=	39000	nM
78	Ki	=	78000	nM
0.043	IC50	=	43	nM
8	Ki	=	8000	nM
0.7	Ki	=	700	nM

213971-33-6 靶点实验数据