HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5105246

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 19.0
First Page: 12639
Last Page: 12649
DOI: 10.1021/acs.jmedchem.2c00201

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
38.02	Solubility	=	38020	nM
	Log S	=	-4.42
0.32	Solubility	<	320	nM
0.51	Solubility	=	510	nM
	Log S	=	-6.29
1.23	Solubility	=	1230	nM
0.87	Solubility	<	870	nM
1.23	Solubility	=	1230	nM
52.48	Solubility	=	52480	nM
0.58	Solubility	=	580	nM
	Log S	=	-6.24
630.96	Solubility	=	630960	nM
0.72	Solubility	<	720	nM
2.63	Solubility	=	2630	nM
	Log S	=	-5.58
6.92	Solubility	=	6920	nM
	Log S	=	-5.16
	Log S	>	-2.6
331.13	Solubility	=	331130	nM
50.12	Solubility	=	50120	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Peregrin

External ID: CHEMBL4650107

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL3132741
ChEMBL Target Name: Peregrin
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Delta TM	=	-1.78	C
Delta TM	=	-1.51	C	Thermal Shift Assay
Delta TM	=	-1.41	C	Thermal Shift Assay
Delta TM	=	-1.6	C
Delta TM	=	-2.24	C	Thermal Shift Assay
Delta TM	=	-2.09	C	Thermal Shift Assay
Delta TM	=	-2.28	C	Thermal Shift Assay
Delta TM	=	-1.96	C	Thermal Shift Assay
Delta TM	=	-1.24	C	Thermal Shift Assay
Delta TM	=	-1.64	C	Thermal Shift Assay
Delta TM	=	-3.24	C
Delta TM	=	-2.18	C	Thermal Shift Assay
Delta TM	=	-2.03	C
Delta TM	=	-1.92	C	Thermal Shift Assay
Delta TM	=	-2.24	C
Delta TM	=	-2.19	C	Thermal Shift Assay
Delta TM	=	-2.72	C
Delta TM	=	-1.9	C	Thermal Shift Assay
Delta TM	=	0	C
Delta TM	=	-0.4	C

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cyclin-dependent kinase 2

External ID: CHEMBL5062802

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL301
ChEMBL Target Name: Cyclin-dependent kinase 2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Delta TM	=	0.1409	C	Thermal Shift Assay
Delta TM	=	-0.01457	C	Thermal Shift Assay
Delta TM	=	-0.19	C
Delta TM	=	1.16	C	Thermal Shift Assay
Delta TM	=	1.921	C	Thermal Shift Assay
Delta TM	=	-0.3406	C	Thermal Shift Assay
Delta TM	=	0.6	C	Thermal Shift Assay
Delta TM	=	-0.1127	C	Thermal Shift Assay
Delta TM	=	-1.169	C	Thermal Shift Assay
Delta TM	=	0.82	C
Delta TM	=	0.31	C	Thermal Shift Assay
Delta TM	=	-0.02	C	Thermal Shift Assay
Delta TM	=	0.46	C	Thermal Shift Assay
Delta TM	=	-1.475	C	Thermal Shift Assay
Delta TM	=	-0.6313	C	Thermal Shift Assay
Delta TM	=	0	C	Thermal Shift Assay
Delta TM	=	-0.6762	C	Thermal Shift Assay
Delta TM	=	1.46	C	Thermal Shift Assay
Delta TM	=	0.98	C	Thermal Shift Assay
Delta TM	=	0.83	C	Thermal Shift Assay

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cyclin-dependent kinase 9

External ID: CHEMBL5367571

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2023
Volume: 66
Issue: 18
First Page: 12877
Last Page: 12893
DOI: 10.1021/acs.jmedchem.3c00828

Target ChEMBL ID: CHEMBL2111389
ChEMBL Target Name: CDK9/cyclin T1
ChEMBL Target Type: PROTEIN COMPLEX - Target is a defined protein complex, consisting of multiple subunits
Relationship Type: D - Direct protein target assigned
Confidence: Direct protein complex subunits assigned

Standard Type	Activity Comment
Activity	Active
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cyclin-dependent kinase 9

External ID: CHEMBL5367569

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2023
Volume: 66
Issue: 18
First Page: 12877
Last Page: 12893
DOI: 10.1021/acs.jmedchem.3c00828

Target ChEMBL ID: CHEMBL3116
ChEMBL Target Name: Cyclin-dependent kinase 9
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	39	%
Inhibition	=	65	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：U2932

External ID: CHEMBL5367570

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2023
Volume: 66
Issue: 18
First Page: 12877
Last Page: 12893
DOI: 10.1021/acs.jmedchem.3c00828

Target ChEMBL ID: CHEMBL4296507
ChEMBL Target Name: U2932
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.32	IC50	=	320	nM
0.104	IC50	=	104	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cyclin-dependent kinase 9

External ID: CHEMBL5367568

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2023
Volume: 66
Issue: 18
First Page: 12877
Last Page: 12893
DOI: 10.1021/acs.jmedchem.3c00828

Target ChEMBL ID: CHEMBL3116
ChEMBL Target Name: Cyclin-dependent kinase 9
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
Inhibition	=	4	%
Inhibition	=	1	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：CWR22R

External ID: CHEMBL5118754

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 16.0
First Page: 11034
Last Page: 11057
DOI: 10.1021/acs.jmedchem.2c00257

Target ChEMBL ID: CHEMBL612657
ChEMBL Target Name: CWR22R
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Units	Activity Comment
Inhibition	%	Active
Inhibition	%	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：CWR22R

External ID: CHEMBL5118755

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 16.0
First Page: 11034
Last Page: 11057
DOI: 10.1021/acs.jmedchem.2c00257

Target ChEMBL ID: CHEMBL612657
ChEMBL Target Name: CWR22R
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Active
Activity	Active
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：CWR22R

External ID: CHEMBL5118756

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 16.0
First Page: 11034
Last Page: 11057
DOI: 10.1021/acs.jmedchem.2c00257

Target ChEMBL ID: CHEMBL612657
ChEMBL Target Name: CWR22R
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Active
Activity	Active
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：CWR22R

External ID: CHEMBL5118757

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 16.0
First Page: 11034
Last Page: 11057
DOI: 10.1021/acs.jmedchem.2c00257

Target ChEMBL ID: CHEMBL612657
ChEMBL Target Name: CWR22R
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Active
Activity	Active
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Glycogen synthase kinase-3 beta

External ID: CHEMBL5065589

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL262
ChEMBL Target Name: Glycogen synthase kinase-3 beta
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Delta TM	=	5.443	C	Thermal Shift Assay
Delta TM	=	-0.3085	C	Thermal Shift Assay
Delta TM	=	-0.7	C
Delta TM	=	-0.03	C	Thermal Shift Assay
Delta TM	=	11.17	C	Thermal Shift Assay
Delta TM	=	-1.553	C	Thermal Shift Assay
Delta TM	=	-0.29	C	Thermal Shift Assay
Delta TM	=	-0.3615	C	Thermal Shift Assay
Delta TM	=	0.0664	C	Thermal Shift Assay
Delta TM	=	-0.66	C
Delta TM	=	-0.06	C	Thermal Shift Assay
Delta TM	=	-0.21	C	Thermal Shift Assay
Delta TM	=	-0.26	C	Thermal Shift Assay
Delta TM	=	-1.145	C	Thermal Shift Assay
Delta TM	=	-0.6697	C	Thermal Shift Assay
Delta TM	=	0	C	Thermal Shift Assay
Delta TM	=	-0.4876	C	Thermal Shift Assay
Delta TM	=	2.74	C	Thermal Shift Assay
Delta TM	=	0.22	C	Thermal Shift Assay
Delta TM	=	-0.06	C	Thermal Shift Assay

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Tyrosine-protein kinase ABL1

External ID: CHEMBL5060015

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL1862
ChEMBL Target Name: Tyrosine-protein kinase ABL
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Delta TM	=	2.866	C	Thermal Shift Assay
Delta TM	=	-0.1161	C	Thermal Shift Assay
Delta TM	=	0.32	C
Delta TM	=	0.12	C	Thermal Shift Assay
Delta TM	=	1.321	C	Thermal Shift Assay
Delta TM	=	-0.3289	C	Thermal Shift Assay
Delta TM	=	0.97	C	Thermal Shift Assay
Delta TM	=	-0.00477	C	Thermal Shift Assay
Delta TM	=	0.8545	C	Thermal Shift Assay
Delta TM	=	0.25	C
Delta TM	=	0.05	C	Thermal Shift Assay
Delta TM	=	0.01	C	Thermal Shift Assay
Delta TM	=	0.57	C	Thermal Shift Assay
Delta TM	=	-0.2514	C	Thermal Shift Assay
Delta TM	=	-0.09405	C	Thermal Shift Assay
Delta TM	=	0.1211	C	Thermal Shift Assay
Delta TM	=	0.2152	C	Thermal Shift Assay
Delta TM	=	4.95	C	Thermal Shift Assay
Delta TM	=	0.78	C	Thermal Shift Assay
Delta TM	=	0.49	C	Thermal Shift Assay

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cyclin-dependent kinase 9

External ID: CHEMBL5118683

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 16.0
First Page: 11034
Last Page: 11057
DOI: 10.1021/acs.jmedchem.2c00257

Target ChEMBL ID: CHEMBL3116
ChEMBL Target Name: Cyclin-dependent kinase 9
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cyclin-dependent kinase 9

External ID: CHEMBL5118679

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 16.0
First Page: 11034
Last Page: 11057
DOI: 10.1021/acs.jmedchem.2c00257

Target ChEMBL ID: CHEMBL3116
ChEMBL Target Name: Cyclin-dependent kinase 9
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cyclin-T1

External ID: CHEMBL5118680

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 16.0
First Page: 11034
Last Page: 11057
DOI: 10.1021/acs.jmedchem.2c00257

Target ChEMBL ID: CHEMBL2108
ChEMBL Target Name: Cyclin T1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	40.18	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：CWR22R

External ID: CHEMBL5118681

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 16.0
First Page: 11034
Last Page: 11057
DOI: 10.1021/acs.jmedchem.2c00257

Target ChEMBL ID: CHEMBL612657
ChEMBL Target Name: CWR22R
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Units	Activity Comment
Inhibition	%	Active
Inhibition	%	NA

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cyclin-dependent kinase 9

External ID: CHEMBL5118802

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 16.0
First Page: 11034
Last Page: 11057
DOI: 10.1021/acs.jmedchem.2c00257

Target ChEMBL ID: CHEMBL3116
ChEMBL Target Name: Cyclin-dependent kinase 9
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cyclin-dependent kinase 9

External ID: CHEMBL5118798

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 16.0
First Page: 11034
Last Page: 11057
DOI: 10.1021/acs.jmedchem.2c00257

Target ChEMBL ID: CHEMBL3116
ChEMBL Target Name: Cyclin-dependent kinase 9
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	NA

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cyclin-dependent kinase 9

External ID: CHEMBL5118799

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 16.0
First Page: 11034
Last Page: 11057
DOI: 10.1021/acs.jmedchem.2c00257

Target ChEMBL ID: CHEMBL3116
ChEMBL Target Name: Cyclin-dependent kinase 9
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	NA

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cyclin-dependent kinase 9

External ID: CHEMBL5118800

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 16.0
First Page: 11034
Last Page: 11057
DOI: 10.1021/acs.jmedchem.2c00257

Target ChEMBL ID: CHEMBL3116
ChEMBL Target Name: Cyclin-dependent kinase 9
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cyclin-dependent kinase 9

External ID: CHEMBL5118801

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 16.0
First Page: 11034
Last Page: 11057
DOI: 10.1021/acs.jmedchem.2c00257

Target ChEMBL ID: CHEMBL3116
ChEMBL Target Name: Cyclin-dependent kinase 9
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cyclin-dependent kinase 9

External ID: CHEMBL5118794

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 16.0
First Page: 11034
Last Page: 11057
DOI: 10.1021/acs.jmedchem.2c00257

Target ChEMBL ID: CHEMBL3116
ChEMBL Target Name: Cyclin-dependent kinase 9
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	NA

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cyclin-dependent kinase 9

External ID: CHEMBL5118795

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 16.0
First Page: 11034
Last Page: 11057
DOI: 10.1021/acs.jmedchem.2c00257

Target ChEMBL ID: CHEMBL3116
ChEMBL Target Name: Cyclin-dependent kinase 9
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	NA

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cyclin-dependent kinase 9

External ID: CHEMBL5118796

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 16.0
First Page: 11034
Last Page: 11057
DOI: 10.1021/acs.jmedchem.2c00257

Target ChEMBL ID: CHEMBL3116
ChEMBL Target Name: Cyclin-dependent kinase 9
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	NA

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cyclin-dependent kinase 9

External ID: CHEMBL5118797

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 16.0
First Page: 11034
Last Page: 11057
DOI: 10.1021/acs.jmedchem.2c00257

Target ChEMBL ID: CHEMBL3116
ChEMBL Target Name: Cyclin-dependent kinase 9
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	NA

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cyclin-dependent kinase 9

External ID: CHEMBL5118790

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 16.0
First Page: 11034
Last Page: 11057
DOI: 10.1021/acs.jmedchem.2c00257

Target ChEMBL ID: CHEMBL3116
ChEMBL Target Name: Cyclin-dependent kinase 9
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	NA

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cyclin-dependent kinase 9

External ID: CHEMBL5118791

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 16.0
First Page: 11034
Last Page: 11057
DOI: 10.1021/acs.jmedchem.2c00257

Target ChEMBL ID: CHEMBL3116
ChEMBL Target Name: Cyclin-dependent kinase 9
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	NA

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cyclin-dependent kinase 9

External ID: CHEMBL5118792

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 16.0
First Page: 11034
Last Page: 11057
DOI: 10.1021/acs.jmedchem.2c00257

Target ChEMBL ID: CHEMBL3116
ChEMBL Target Name: Cyclin-dependent kinase 9
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	NA

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cyclin-dependent kinase 9

External ID: CHEMBL5118793

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 16.0
First Page: 11034
Last Page: 11057
DOI: 10.1021/acs.jmedchem.2c00257

Target ChEMBL ID: CHEMBL3116
ChEMBL Target Name: Cyclin-dependent kinase 9
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	NA

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：U2932

External ID: CHEMBL5367595

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2023
Volume: 66
Issue: 18
First Page: 12877
Last Page: 12893
DOI: 10.1021/acs.jmedchem.3c00828

Target ChEMBL ID: CHEMBL4296507
ChEMBL Target Name: U2932
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	1.55	%
Activity	=	2.08	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cyclin-dependent kinase 9

External ID: CHEMBL5118786

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 16.0
First Page: 11034
Last Page: 11057
DOI: 10.1021/acs.jmedchem.2c00257

Target ChEMBL ID: CHEMBL3116
ChEMBL Target Name: Cyclin-dependent kinase 9
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cyclin-dependent kinase 9

External ID: CHEMBL5118787

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 16.0
First Page: 11034
Last Page: 11057
DOI: 10.1021/acs.jmedchem.2c00257

Target ChEMBL ID: CHEMBL3116
ChEMBL Target Name: Cyclin-dependent kinase 9
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：U2932

External ID: CHEMBL5367593

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2023
Volume: 66
Issue: 18
First Page: 12877
Last Page: 12893
DOI: 10.1021/acs.jmedchem.3c00828

Target ChEMBL ID: CHEMBL4296507
ChEMBL Target Name: U2932
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	8.93	%
Activity	=	11.8	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cyclin-dependent kinase 9

External ID: CHEMBL5118788

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 16.0
First Page: 11034
Last Page: 11057
DOI: 10.1021/acs.jmedchem.2c00257

Target ChEMBL ID: CHEMBL3116
ChEMBL Target Name: Cyclin-dependent kinase 9
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	NA

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：U2932

External ID: CHEMBL5367594

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2023
Volume: 66
Issue: 18
First Page: 12877
Last Page: 12893
DOI: 10.1021/acs.jmedchem.3c00828

Target ChEMBL ID: CHEMBL4296507
ChEMBL Target Name: U2932
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	22.3	%
Activity	=	38.7	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5621185

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2023
Volume: 257
First Page: 115447
Last Page: 115447
DOI: 10.1016/j.ejmech.2023.115447

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	~	99	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cyclin-dependent kinase 9

External ID: CHEMBL5118789

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 16.0
First Page: 11034
Last Page: 11057
DOI: 10.1021/acs.jmedchem.2c00257

Target ChEMBL ID: CHEMBL3116
ChEMBL Target Name: Cyclin-dependent kinase 9
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	NA

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：U2932

External ID: CHEMBL5367592

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2023
Volume: 66
Issue: 18
First Page: 12877
Last Page: 12893
DOI: 10.1021/acs.jmedchem.3c00828

Target ChEMBL ID: CHEMBL4296507
ChEMBL Target Name: U2932
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	67.2	%
Activity	=	47.4	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cyclin-dependent kinase 9

External ID: CHEMBL5118784

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 16.0
First Page: 11034
Last Page: 11057
DOI: 10.1021/acs.jmedchem.2c00257

Target ChEMBL ID: CHEMBL3116
ChEMBL Target Name: Cyclin-dependent kinase 9
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mitogen-activated protein kinase 1

External ID: CHEMBL5066518

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL4040
ChEMBL Target Name: MAP kinase ERK2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Delta TM	=	-0.03532	C	Thermal Shift Assay
Delta TM	=	-0.09791	C	Thermal Shift Assay
Delta TM	=	-0.72	C
Delta TM	=	0.39	C	Thermal Shift Assay
Delta TM	=	0.6544	C	Thermal Shift Assay
Delta TM	=	0.01068	C	Thermal Shift Assay
Delta TM	=	0.05	C	Thermal Shift Assay
Delta TM	=	0.3911	C	Thermal Shift Assay
Delta TM	=	-0.1368	C	Thermal Shift Assay
Delta TM	=	0.38	C
Delta TM	=	0.18	C	Thermal Shift Assay
Delta TM	=	0.02	C	Thermal Shift Assay
Delta TM	=	0.24	C	Thermal Shift Assay
Delta TM	=	-0.1886	C	Thermal Shift Assay
Delta TM	=	-0.3286	C	Thermal Shift Assay
Delta TM	=	-0.9406	C	Thermal Shift Assay
Delta TM	=	-0.6238	C	Thermal Shift Assay
Delta TM	=	0.17	C	Thermal Shift Assay
Delta TM	=	0.35	C	Thermal Shift Assay
Delta TM	=	0.08	C	Thermal Shift Assay

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cyclin-dependent kinase 9

External ID: CHEMBL5118785

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 16.0
First Page: 11034
Last Page: 11057
DOI: 10.1021/acs.jmedchem.2c00257

Target ChEMBL ID: CHEMBL3116
ChEMBL Target Name: Cyclin-dependent kinase 9
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cyclin-T1

External ID: CHEMBL5118714

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 16.0
First Page: 11034
Last Page: 11057
DOI: 10.1021/acs.jmedchem.2c00257

Target ChEMBL ID: CHEMBL2108
ChEMBL Target Name: Cyclin T1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Bromodomain-containing protein 4

External ID: CHEMBL5060944

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL1163125
ChEMBL Target Name: Bromodomain-containing protein 4
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value	Standard Units
Delta TM	=	-3.51	C
Delta TM	=	-12.67	C
Delta TM	=	-0.61	C
Delta TM	=	1.2	C
Delta TM	=	-2.16	C
Delta TM	=	-11.41	C
Delta TM	=	-0.76	C
Delta TM	=	-4.31	C
Delta TM	=	3.95	C
Delta TM	=	-0.38	C
Delta TM	=	-2.21	C
Delta TM	=	0.44	C
Delta TM	=	-2.86	C
Delta TM	=	0.42	C
Delta TM	=	-0.39	C
Delta TM	=	1.17	C
Delta TM	=	-2.45	C
Delta TM	=	-1.48	C
Delta TM	=	-0.92	C
Delta TM	=	-2.44	C

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cyclin-dependent kinase 16

External ID: CHEMBL5118710

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 16.0
First Page: 11034
Last Page: 11057
DOI: 10.1021/acs.jmedchem.2c00257

Target ChEMBL ID: CHEMBL4597
ChEMBL Target Name: Serine/threonine-protein kinase PCTAIRE-1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	NA
Activity	NA

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cyclin-dependent kinase 19

External ID: CHEMBL5118711

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 16.0
First Page: 11034
Last Page: 11057
DOI: 10.1021/acs.jmedchem.2c00257

Target ChEMBL ID: CHEMBL6002
ChEMBL Target Name: Cell division cycle 2-like protein kinase 6
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	NA
Activity	NA

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cyclin-dependent kinase 7

External ID: CHEMBL5118706

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 16.0
First Page: 11034
Last Page: 11057
DOI: 10.1021/acs.jmedchem.2c00257

Target ChEMBL ID: CHEMBL3055
ChEMBL Target Name: Cyclin-dependent kinase 7
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	Active
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cyclin-dependent kinase 2

External ID: CHEMBL5118707

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 16.0
First Page: 11034
Last Page: 11057
DOI: 10.1021/acs.jmedchem.2c00257

Target ChEMBL ID: CHEMBL301
ChEMBL Target Name: Cyclin-dependent kinase 2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	NA
Activity	Active
Activity	NA

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cyclin-dependent kinase 11B

External ID: CHEMBL5118709

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 16.0
First Page: 11034
Last Page: 11057
DOI: 10.1021/acs.jmedchem.2c00257

Target ChEMBL ID: CHEMBL5808
ChEMBL Target Name: PITSLRE serine/threonine-protein kinase CDC2L1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	NA
Activity	Active
Activity	NA

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cyclin-dependent kinase 1

External ID: CHEMBL5118703

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 16.0
First Page: 11034
Last Page: 11057
DOI: 10.1021/acs.jmedchem.2c00257

Target ChEMBL ID: CHEMBL308
ChEMBL Target Name: Cyclin-dependent kinase 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	Active
Activity	Active

2139287-33-3 靶点实验数据