HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Bromodomain-containing protein 4

External ID: CHEMBL4033128

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2017
Volume: 60
Issue: 24
First Page: 9990
Last Page: 10012
DOI: 10.1021/acs.jmedchem.7b00275

Target ChEMBL ID: CHEMBL1163125
ChEMBL Target Name: Bromodomain-containing protein 4
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
10	IC50	>	10000	nM
0.073	IC50	=	73	nM
0.72	IC50	=	720	nM
10	IC50	>	10000	nM
4.31	IC50	=	4310	nM
8.59	IC50	=	8590	nM
10	IC50	>	10000	nM
1.02	IC50	=	1020	nM
10	IC50	>	10000	nM
10	IC50	>	10000	nM
10	IC50	>	10000	nM
0.43	IC50	=	430	nM
1.04	IC50	=	1040	nM
10	IC50	>	10000	nM
10	IC50	>	10000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Bromodomain-containing protein 4

External ID: CHEMBL4033137

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2017
Volume: 60
Issue: 24
First Page: 9990
Last Page: 10012
DOI: 10.1021/acs.jmedchem.7b00275

Target ChEMBL ID: CHEMBL1163125
ChEMBL Target Name: Bromodomain-containing protein 4
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	18.81	%
Activity	=	8.7	%
Activity	=	33.17	%
Activity	=	12.3	%
Activity	=	7.51	%
Activity	=	20.31	%
Activity	=	8.38	%
Activity	=	25.62	%
Activity	=	27.22	%
Activity	=	26.98	%
Activity	=	19.79	%
Activity	=	26.66	%
Activity	=	42.29	%
Activity	=	30.79	%
Activity	=	25.99	%
Activity	=	10.43	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：MCF7

External ID: CHEMBL4033129

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2017
Volume: 60
Issue: 24
First Page: 9990
Last Page: 10012
DOI: 10.1021/acs.jmedchem.7b00275

Target ChEMBL ID: CHEMBL387
ChEMBL Target Name: MCF7
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
30	IC50	>	30000	nM
28.75	IC50	=	28750	nM
5.48	IC50	=	5480	nM
30	IC50	>	30000	nM
12.19	IC50	=	12190	nM
30	IC50	>	30000	nM
30	IC50	>	30000	nM
2.69	IC50	=	2690	nM
30	IC50	>	30000	nM
30	IC50	>	30000	nM
30	IC50	>	30000	nM
1.62	IC50	=	1620	nM
2.17	IC50	=	2170	nM
30	IC50	>	30000	nM
30	IC50	>	30000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：MDA-MB-231

External ID: CHEMBL4033130

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2017
Volume: 60
Issue: 24
First Page: 9990
Last Page: 10012
DOI: 10.1021/acs.jmedchem.7b00275

Target ChEMBL ID: CHEMBL400
ChEMBL Target Name: MDA-MB-231
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
30	IC50	>	30000	nM
33.04	IC50	=	33040	nM
8.29	IC50	=	8290	nM
30	IC50	>	30000	nM
22.85	IC50	=	22850	nM
28.35	IC50	=	28350	nM
30	IC50	>	30000	nM
16.26	IC50	=	16260	nM
30	IC50	>	30000	nM
30	IC50	>	30000	nM
30	IC50	>	30000	nM
3.27	IC50	=	3270	nM
8.31	IC50	=	8310	nM
30	IC50	>	30000	nM
30	IC50	>	30000	nM

2118944-75-3 靶点实验数据