HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：A549

External ID: CHEMBL2388451

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2013
Volume: 76
Issue: 6
First Page: 1058
Last Page: 1063
DOI: 10.1021/np4000747

Target ChEMBL ID: CHEMBL392
ChEMBL Target Name: A549
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：BGC-823

External ID: CHEMBL2388450

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2013
Volume: 76
Issue: 6
First Page: 1058
Last Page: 1063
DOI: 10.1021/np4000747

Target ChEMBL ID: CHEMBL614526
ChEMBL Target Name: BGC-823
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Nuclear factor erythroid 2-related factor 2

External ID: CHEMBL4034550

Protocol: N/A

Comment: Journal: Bioorg Med Chem
Year: 2017
Volume: 25
Issue: 12
First Page: 3135
Last Page: 3147
DOI: 10.1016/j.bmc.2017.03.069

Target ChEMBL ID: CHEMBL1075094
ChEMBL Target Name: Nuclear factor erythroid 2-related factor 2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value
FC	=	1.7

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Bel-7402

External ID: CHEMBL2388449

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2013
Volume: 76
Issue: 6
First Page: 1058
Last Page: 1063
DOI: 10.1021/np4000747

Target ChEMBL ID: CHEMBL614279
ChEMBL Target Name: Bel-7402
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Signal transducer and activator of transcription 3

External ID: CHEMBL4034551

Protocol: N/A

Comment: Journal: Bioorg Med Chem
Year: 2017
Volume: 25
Issue: 12
First Page: 3135
Last Page: 3147
DOI: 10.1016/j.bmc.2017.03.069

Target ChEMBL ID: CHEMBL4026
ChEMBL Target Name: Signal transducer and activator of transcription 3
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	3.5	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4034549

Protocol: N/A

Comment: Journal: Bioorg Med Chem
Year: 2017
Volume: 25
Issue: 12
First Page: 3135
Last Page: 3147
DOI: 10.1016/j.bmc.2017.03.069

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	61.5	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Coxsackievirus

External ID: CHEMBL2388454

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Nat. Prod.
Year: 2013
Volume: 76
Issue: 6
First Page: 1058
Last Page: 1063
DOI: 10.1021/np4000747

Target ChEMBL ID: CHEMBL613750
ChEMBL Target Name: Coxsackievirus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
222.2	IC50	=	222200	nM	Outside typical range
20	IC50	>	20000	nM
20	IC50	>	20000	nM
1.4	IC50	=	1400	nM
11.3	IC50	=	11300	nM
7.4	IC50	=	7400	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Liver microsomes

External ID: CHEMBL2388453

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Nat Prod
Year: 2013
Volume: 76
Issue: 6
First Page: 1058
Last Page: 1063
DOI: 10.1021/np4000747

Target ChEMBL ID: CHEMBL613694
ChEMBL Target Name: Liver microsomes
ChEMBL Target Type: SUBCELLULAR - Target is a subcellular fraction
Relationship Type: S - Subcellular target assigned
Confidence: Target assigned is subcellular fraction

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
	IC50				Not Active
23.8	IC50	=	23800	nM
14.7	IC50	=	14700	nM
4.9	IC50	=	4900	nM
	IC50				Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL990220

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2001
Volume: 64
Issue: 7
First Page: 861
Last Page: 864
DOI: 10.1021/np0005107

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	60.53	%
Inhibition	=	67.42	%
Inhibition	=	14.17	%
Inhibition	=	46.31	%
Inhibition	=	31.58	%
Inhibition	=	41.71	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HT-29

External ID: CHEMBL939645

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2008
Volume: 71
Issue: 7
First Page: 1173
Last Page: 1177
DOI: 10.1021/np800055q

Target ChEMBL ID: CHEMBL384
ChEMBL Target Name: HT-29
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
IC50	>	5	ug.mL-1
IC50	=	0.18	ug.mL-1
IC50	>	5	ug.mL-1
IC50	=	2.9	ug.mL-1
IC50	=	2.37	ug.mL-1
IC50	>	5	ug.mL-1
IC50	>	5	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HeLa

External ID: CHEMBL939644

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2008
Volume: 71
Issue: 7
First Page: 1173
Last Page: 1177
DOI: 10.1021/np800055q

Target ChEMBL ID: CHEMBL399
ChEMBL Target Name: HeLa
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
IC50	=	0.08	ug.mL-1
IC50	=	0.55	ug.mL-1
IC50	>	5	ug.mL-1
IC50	=	3.4	ug.mL-1
IC50	=	0.95	ug.mL-1
IC50	=	2.8	ug.mL-1
IC50	>	5	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Bacillus subtilis

External ID: CHEMBL940438

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2008
Volume: 71
Issue: 7
First Page: 1173
Last Page: 1177
DOI: 10.1021/np800055q

Target ChEMBL ID: CHEMBL359
ChEMBL Target Name: Bacillus subtilis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	1.17	ug.mL-1
MIC	=	4.69	ug.mL-1
MIC	=	0.59	ug.mL-1
MIC	=	4.69	ug.mL-1
MIC	=	4.69	ug.mL-1
MIC	=	2.34	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：KB

External ID: CHEMBL940437

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2008
Volume: 71
Issue: 7
First Page: 1173
Last Page: 1177
DOI: 10.1021/np800055q

Target ChEMBL ID: CHEMBL398
ChEMBL Target Name: KB
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
IC50	=	0.04	ug.mL-1
IC50	=	0.4	ug.mL-1
IC50	>	5	ug.mL-1
IC50	=	3	ug.mL-1
IC50	=	3.1	ug.mL-1
IC50	=	4.9	ug.mL-1
IC50	>	5	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：A2780

External ID: CHEMBL2388448

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2013
Volume: 76
Issue: 6
First Page: 1058
Last Page: 1063
DOI: 10.1021/np4000747

Target ChEMBL ID: CHEMBL614004
ChEMBL Target Name: A2780
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HCT-8

External ID: CHEMBL2388447

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2013
Volume: 76
Issue: 6
First Page: 1058
Last Page: 1063
DOI: 10.1021/np4000747

Target ChEMBL ID: CHEMBL613510
ChEMBL Target Name: HCT-8
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：MCF7

External ID: CHEMBL939643

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2008
Volume: 71
Issue: 7
First Page: 1173
Last Page: 1177
DOI: 10.1021/np800055q

Target ChEMBL ID: CHEMBL387
ChEMBL Target Name: MCF7
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
IC50				Not Determined
IC50	=	0.05	ug.mL-1
IC50	>	5	ug.mL-1
IC50	=	2.35	ug.mL-1
IC50	=	1.85	ug.mL-1
IC50	=	0.8	ug.mL-1
IC50	>	5	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NIH3T3

External ID: CHEMBL4034569

Protocol: N/A

Comment: Journal: Bioorg Med Chem
Year: 2017
Volume: 25
Issue: 12
First Page: 3135
Last Page: 3147
DOI: 10.1016/j.bmc.2017.03.069

Target ChEMBL ID: CHEMBL614822
ChEMBL Target Name: NIH3T3
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Non-Toxic

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL3404454

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2015
Volume: 25
Issue: 7
First Page: 1483
Last Page: 1489
DOI: 10.1016/j.bmcl.2015.02.026

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
1.1	GI50	=	1100	nM
34.39	GI50	=	34390	nM
50.93	GI50	=	50930	nM
38.04	GI50	=	38040	nM
27.45	GI50	=	27450	nM

2102-75-2 靶点实验数据