HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Plasmodium falciparum

External ID: CHEMBL1040691

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Proc Natl Acad Sci U S A
Year: 2008
Volume: 105
Issue: 26
First Page: 9059
Last Page: 9064
DOI: 10.1073/pnas.0802982105

Target ChEMBL ID: CHEMBL364
ChEMBL Target Name: Plasmodium falciparum
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Data Source: Novartis Malaria Screening

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.2485	EC50	=	248.5	nM
0.0688	EC50	=	68.8	nM
0.0744	EC50	=	74.4	nM
0.2605	EC50	=	260.5	nM
0.364	EC50	=	364	nM
0.342	EC50	=	342	nM
0.441	EC50	=	441	nM
0.652	EC50	=	652	nM
0.0977	EC50	=	97.7	nM
0.2631	EC50	=	263.1	nM
0.352	EC50	=	352	nM
0.01413	EC50	=	14.13	nM
1.099	EC50	=	1099	nM
0.2072	EC50	=	207.2	nM
0.0825	EC50	=	82.5	nM
0.0404	EC50	=	40.4	nM
0.0831	EC50	=	83.1	nM
0.7	EC50	=	700	nM
0.1714	EC50	=	171.4	nM
0.1067	EC50	=	106.7	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：BindingDB 靶标：N/A

External ID: BindingDB_895_1

Protocol: N/A

Comment: Compounds with any of Ki, IC50, Kd, or EC50 activity value <= 10uM are labeled as "Active".
If multiple measurements are available for a given compound, it is labeled as "Active" if any of the measurements meet the criterion. Activity values are checked in the order of Ki, IC50, Kd, and EC50. The first entry that meets the above activity threshold is used to determine "Standard Type", "Standard Relation", and "PubChem Standard Value". Otherwise, the first non-empty entry will be used to set those values.

Standard Type	PubChem Standard Value	IC50	Target Accession(s)	Ligand	Target
IC50	197	197000	P11802,P24385	BDBM6957	Cyclin-dependent kinase 4/G1/S-specific cyclin-D1
IC50	605	605000	P11802,P24385	BDBM6958	Cyclin-dependent kinase 4/G1/S-specific cyclin-D1
IC50	59	59000	P11802,P24385	BDBM6959	Cyclin-dependent kinase 4/G1/S-specific cyclin-D1
IC50	2.3	2300	P11802,P24385	BDBM6960	Cyclin-dependent kinase 4/G1/S-specific cyclin-D1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cyclin-dependent kinase 4

External ID: CHEMBL666611

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2001
Volume: 11
Issue: 16
First Page: 2209
Last Page: 2211
DOI: 10.1016/s0960-894x(01)00416-4

Target ChEMBL ID: CHEMBL1907601
ChEMBL Target Name: Cyclin-dependent kinase 4/cyclin D1
ChEMBL Target Type: PROTEIN COMPLEX - Target is a defined protein complex, consisting of multiple subunits
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous protein complex subunits assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
159	IC50	=	159000	nM	Outside typical range
1.9	IC50	=	1900	nM
2.3	IC50	=	2300	nM
309	IC50	>	309000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1040694

Protocol: N/A

Comment: Journal: Proc Natl Acad Sci U S A
Year: 2008
Volume: 105
Issue: 26
First Page: 9059
Last Page: 9064
DOI: 10.1073/pnas.0802982105

Data Source: Novartis Malaria Screening

Standard Type	Standard Relation	Standard Value	Standard Units
IFI	=	12.4	%
IFI	=	0	%
IFI	=	4.118	%
IFI	=	6.952	%
IFI	=	2.614	%
IFI	=	1.163	%
IFI	=	6.061	%
IFI	=	1.84	%
IFI	=	1.613	%
IFI	=	0	%
IFI	=	22.64	%
IFI	=	1.075	%
IFI	=	0	%
IFI	=	14.16	%
IFI	=	0	%
IFI	=	0.7812	%
IFI	=	3.937	%
IFI	=	3.876	%
IFI	=	7.092	%
IFI	=	0.5495	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Plasmodium falciparum

External ID: CHEMBL1040692

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Proc Natl Acad Sci U S A
Year: 2008
Volume: 105
Issue: 26
First Page: 9059
Last Page: 9064
DOI: 10.1073/pnas.0802982105

Target ChEMBL ID: CHEMBL364
ChEMBL Target Name: Plasmodium falciparum
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Data Source: Novartis Malaria Screening

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.01422	EC50	=	14.22	nM
0.0687	EC50	=	68.7	nM
0.0837	EC50	=	83.7	nM
0.46	EC50	=	460	nM
0.442	EC50	=	442	nM
0.766	EC50	=	766	nM
1.655	EC50	=	1655	nM
0.1708	EC50	=	170.8	nM
0.958	EC50	=	958	nM
0.338	EC50	=	338	nM
0.3142	EC50	=	314.2	nM
0.627	EC50	=	627	nM
0.0841	EC50	=	84.1	nM
0.711	EC50	=	711	nM
0.2319	EC50	=	231.9	nM
0.547	EC50	=	547	nM
0.366	EC50	=	366	nM
0.1165	EC50	=	116.5	nM
1.25	EC50	>	1250	nM
1.601	EC50	=	1601	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Huh-7

External ID: CHEMBL1040693

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Proc Natl Acad Sci U S A
Year: 2008
Volume: 105
Issue: 26
First Page: 9059
Last Page: 9064
DOI: 10.1073/pnas.0802982105

Target ChEMBL ID: CHEMBL614039
ChEMBL Target Name: Huh-7
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Data Source: Novartis Malaria Screening

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
19.61	CC50	=	19610	nM
6.25	CC50	>	6250	nM
12.42	CC50	=	12420	nM
20.22	CC50	=	20220	nM
100	CC50	>	100000	nM
100	CC50	>	100000	nM
8.94	CC50	=	8940	nM
1.587	CC50	=	1587	nM
100	CC50	>	100000	nM
25.8	CC50	=	25800	nM
0.835	CC50	=	835	nM
100	CC50	>	100000	nM
100	CC50	>	100000	nM
10	CC50	>	10000	nM
100	CC50	>	100000	nM
93.22	CC50	>	93220	nM
13.11	CC50	=	13110	nM
28.86	CC50	=	28860	nM
	CC50				Not Determined
37.19	CC50	=	37190	nM

205-29-8 靶点实验数据