HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mycobacterium tuberculosis

External ID: CHEMBL959623

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2008
Volume: 71
Issue: 6
First Page: 1016
Last Page: 1021
DOI: 10.1021/np800097t

Target ChEMBL ID: CHEMBL360
ChEMBL Target Name: Mycobacterium tuberculosis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
388	MIC	=	388000	nM
238	MIC	=	238000	nM
400	MIC	>	400000	nM
400	MIC	>	400000	nM
400	MIC	>	400000	nM
128	MIC	=	128000	nM
209	MIC	=	209000	nM
31.3	MIC	=	31300	nM
126	MIC	=	126000	nM
85.9	MIC	=	85900	nM
105	MIC	=	105000	nM
39.6	MIC	=	39600	nM
215	MIC	=	215000	nM
95	MIC	=	95000	nM
235	MIC	=	235000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：MDA-MB-231

External ID: CHEMBL2379890

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2013
Volume: 23
Issue: 9
First Page: 2738
Last Page: 2742
DOI: 10.1016/j.bmcl.2013.02.060

Target ChEMBL ID: CHEMBL400
ChEMBL Target Name: MDA-MB-231
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
IC50	>	20	ug.mL-1
IC50	>	20	ug.mL-1
IC50	>	20	ug.mL-1
IC50	=	16.74	ug.mL-1
IC50	>	20	ug.mL-1
IC50	>	20	ug.mL-1
IC50	=	0.38	ug.mL-1
IC50	>	20	ug.mL-1
IC50	>	20	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：A549

External ID: CHEMBL2379889

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2013
Volume: 23
Issue: 9
First Page: 2738
Last Page: 2742
DOI: 10.1016/j.bmcl.2013.02.060

Target ChEMBL ID: CHEMBL392
ChEMBL Target Name: A549
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
IC50	>	20	ug.mL-1
IC50	>	20	ug.mL-1
IC50	>	20	ug.mL-1
IC50	=	14.32	ug.mL-1
IC50	>	20	ug.mL-1
IC50	>	20	ug.mL-1
IC50	=	0.26	ug.mL-1
IC50	>	20	ug.mL-1
IC50	>	20	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：BV-2

External ID: CHEMBL4047079

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem Lett
Year: 2017
Volume: 27
Issue: 20
First Page: 4765
Last Page: 4769
DOI: 10.1016/j.bmcl.2017.08.047

Target ChEMBL ID: CHEMBL614781
ChEMBL Target Name: BV-2
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
73.02	IC50	=	73020	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
18.66	IC50	=	18660	nM
100	IC50	>	100000	nM
80.51	IC50	=	80510	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
13.19	IC50	=	13190	nM
39.56	IC50	=	39560	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
18.46	IC50	=	18460	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
6.87	IC50	=	6870	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL2379893

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2013
Volume: 23
Issue: 9
First Page: 2738
Last Page: 2742
DOI: 10.1016/j.bmcl.2013.02.060

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
IC50	>	20	ug.mL-1
IC50	>	13.23	ug.mL-1
IC50	=	15.73	ug.mL-1
IC50	=	16.51	ug.mL-1
IC50	>	20	ug.mL-1
IC50	>	20	ug.mL-1
IC50	=	0.24	ug.mL-1
IC50	>	20	ug.mL-1
IC50	>	20	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HepG2

External ID: CHEMBL2379892

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2013
Volume: 23
Issue: 9
First Page: 2738
Last Page: 2742
DOI: 10.1016/j.bmcl.2013.02.060

Target ChEMBL ID: CHEMBL395
ChEMBL Target Name: HepG2
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
IC50	>	20	ug.mL-1
IC50	>	20	ug.mL-1
IC50	>	20	ug.mL-1
IC50	=	15.27	ug.mL-1
IC50	>	20	ug.mL-1
IC50	>	20	ug.mL-1
IC50	=	0.4	ug.mL-1
IC50	=	13.44	ug.mL-1
IC50	>	20	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：MCF7

External ID: CHEMBL2379891

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2013
Volume: 23
Issue: 9
First Page: 2738
Last Page: 2742
DOI: 10.1016/j.bmcl.2013.02.060

Target ChEMBL ID: CHEMBL387
ChEMBL Target Name: MCF7
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
IC50	>	20	ug.mL-1
IC50	=	17.11	ug.mL-1
IC50	>	20	ug.mL-1
IC50	=	13.41	ug.mL-1
IC50	>	20	ug.mL-1
IC50	>	20	ug.mL-1
IC50	=	0.29	ug.mL-1
IC50	>	20	ug.mL-1
IC50	>	20	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL945506

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 2001
Volume: 64
Issue: 10
First Page: 1305
Last Page: 1308
DOI: 10.1021/np010222q

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	42.6	%
Activity	=	41.3	%
Activity	=	42.8	%
Activity	=	45.7	%
Activity	=	37.2	%
Activity	=	51.6	%
Activity	=	59	%
Activity	=	38.3	%
Activity	=	40.9	%
Activity	=	39.6	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HT-29

External ID: CHEMBL1286346

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2010
Volume: 53
Issue: 21
First Page: 7632
Last Page: 7638
DOI: 10.1021/jm1007769

Target ChEMBL ID: CHEMBL384
ChEMBL Target Name: HT-29
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
50	IC50	>	50000	nM
37.6	IC50	=	37600	nM
15.5	IC50	=	15500	nM
50	IC50	>	50000	nM
50	IC50	>	50000	nM
13.5	IC50	=	13500	nM
50	IC50	>	50000	nM
50	IC50	>	50000	nM
17.6	IC50	=	17600	nM
50	IC50	>	50000	nM
12.9	IC50	=	12900	nM
28	IC50	=	28000	nM
17	IC50	=	17000	nM
24.4	IC50	=	24400	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL945505

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 2001
Volume: 64
Issue: 10
First Page: 1305
Last Page: 1308
DOI: 10.1021/np010222q

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	15.7	%
Activity	=	11.3	%
Activity	=	11.5	%
Activity	=	14.8	%
Activity	=	10	%
Activity	=	26.8	%
Activity	=	33.6	%
Activity	=	10.5	%
Activity	=	11.8	%
Activity	=	10.6	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HEK293

External ID: CHEMBL3378773

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2014
Volume: 22
Issue: 17
First Page: 4597
Last Page: 4601
DOI: 10.1016/j.bmc.2014.07.027

Target ChEMBL ID: CHEMBL614818
ChEMBL Target Name: HEK293
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HEK293

External ID: CHEMBL3378774

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2014
Volume: 22
Issue: 17
First Page: 4597
Last Page: 4601
DOI: 10.1016/j.bmc.2014.07.027

Target ChEMBL ID: CHEMBL614818
ChEMBL Target Name: HEK293
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3378772

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2014
Volume: 22
Issue: 17
First Page: 4597
Last Page: 4601
DOI: 10.1016/j.bmc.2014.07.027

Standard Type	Activity Comment
Activity	Dose-dependent effect
Activity	Dose-dependent effect
Activity	Dose-dependent effect
Activity	Dose-dependent effect

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Raji

External ID: CHEMBL945512

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2001
Volume: 64
Issue: 10
First Page: 1305
Last Page: 1308
DOI: 10.1021/np010222q

Target ChEMBL ID: CHEMBL614628
ChEMBL Target Name: Raji
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Raji

External ID: CHEMBL945511

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2001
Volume: 64
Issue: 10
First Page: 1305
Last Page: 1308
DOI: 10.1021/np010222q

Target ChEMBL ID: CHEMBL614628
ChEMBL Target Name: Raji
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL930441

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2008
Volume: 71
Issue: 1
First Page: 71
Last Page: 75
DOI: 10.1021/np0704349

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
	Inhibition	=	28.73	%
	Inhibition	=	46.11	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL945508

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 2001
Volume: 64
Issue: 10
First Page: 1305
Last Page: 1308
DOI: 10.1021/np010222q

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	100	%
Activity	=	100	%
Activity	=	100	%
Activity	=	100	%
Activity	=	95	%
Activity	=	100	%
Activity	=	100	%
Activity	=	100	%
Activity	=	100	%
Activity	=	100	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL945507

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 2001
Volume: 64
Issue: 10
First Page: 1305
Last Page: 1308
DOI: 10.1021/np010222q

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	77.5	%
Activity	=	75.8	%
Activity	=	71.5	%
Activity	=	73.9	%
Activity	=	70.9	%
Activity	=	77.9	%
Activity	=	83.5	%
Activity	=	71.4	%
Activity	=	70	%
Activity	=	71.5	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Raji

External ID: CHEMBL945510

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2001
Volume: 64
Issue: 10
First Page: 1305
Last Page: 1308
DOI: 10.1021/np010222q

Target ChEMBL ID: CHEMBL614628
ChEMBL Target Name: Raji
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Raji

External ID: CHEMBL945509

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2001
Volume: 64
Issue: 10
First Page: 1305
Last Page: 1308
DOI: 10.1021/np010222q

Target ChEMBL ID: CHEMBL614628
ChEMBL Target Name: Raji
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	70	%
Activity	=	70	%
Activity	=	60	%
Activity	=	60	%
Activity	=	70	%
Activity	=	60	%
Activity	=	70	%
Activity	=	70	%
Activity	=	70	%
Activity	=	70	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL930439

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2008
Volume: 71
Issue: 1
First Page: 71
Last Page: 75
DOI: 10.1021/np0704349

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	22.56	%

2034-74-4 靶点实验数据