HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Phosphatidylinositol 4-kinase alpha

External ID: CHEMBL758627

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1990
Volume: 33
Issue: 8
First Page: 2073
Last Page: 2080
DOI: 10.1021/jm00170a005

Target ChEMBL ID: CHEMBL2096619
ChEMBL Target Name: Phosphatidylinositol 4-kinase, PI4K
ChEMBL Target Type: PROTEIN FAMILY - Target is a group of closely related proteins
Relationship Type: H - Homologous protein target assigned
Confidence: Multiple homologous protein targets may be assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
145.3	IC50	=	145300	nM	Outside typical range
7.1	IC50	=	7100	nM
28.2	IC50	=	28200	nM
6	IC50	=	6000	nM
7.2	IC50	=	7200	nM
7.2	IC50	=	7200	nM
51.9	IC50	=	51900	nM
15.4	IC50	=	15400	nM
126.5	IC50	=	126500	nM	Outside typical range
12.8	IC50	=	12800	nM
82.5	IC50	=	82500	nM
16.1	IC50	=	16100	nM
8.7	IC50	=	8700	nM
21.9	IC50	=	21900	nM
41.1	IC50	=	41100	nM
32.4	IC50	=	32400	nM
144.9	IC50	=	144900	nM	Outside typical range
341.6	IC50	=	341600	nM	Outside typical range
218	IC50	=	218000	nM	Outside typical range
133	IC50	=	133000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Adenosine receptors; A1 & A2

External ID: CHEMBL851397

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1991
Volume: 34
Issue: 9
First Page: 2877
Last Page: 2882
DOI: 10.1021/jm00113a029

Target ChEMBL ID: CHEMBL2094131
ChEMBL Target Name: Adenosine receptors; A1 & A2
ChEMBL Target Type: SELECTIVITY GROUP - Target is a pair of proteins for which the selectivity has been assessed
Relationship Type: H - Homologous protein target assigned
Confidence: Multiple homologous protein targets may be assigned

Standard Type	Standard Relation	Standard Value
Selectivity ratio	=	39
Selectivity ratio	=	26
Selectivity ratio	=	0.82
Selectivity ratio	=	2
Selectivity ratio	=	0.22
Selectivity ratio	=	0.19
Selectivity ratio	=	0.48
Selectivity ratio	=	14
Selectivity ratio	=	4.4
Selectivity ratio	=	9.9
Selectivity ratio	<	0.5

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Adenosine receptor A1

External ID: CHEMBL642197

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1991
Volume: 34
Issue: 9
First Page: 2877
Last Page: 2882
DOI: 10.1021/jm00113a029

Target ChEMBL ID: CHEMBL318
ChEMBL Target Name: Adenosine A1 receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
19	Ki	=	19000	nM
1.8	Ki	=	1800	nM
69	Ki	=	69000	nM
46	Ki	=	46000	nM
3.3	Ki	=	3300	nM
1.2	Ki	=	1200	nM
7	Ki	=	7000	nM
6.9	Ki	=	6900	nM
4.7	Ki	=	4700	nM
100	Ki	>	100000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Phosphatidylinositol 4-kinase alpha

External ID: CHEMBL758630

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1990
Volume: 33
Issue: 8
First Page: 2073
Last Page: 2080
DOI: 10.1021/jm00170a005

Target ChEMBL ID: CHEMBL2096619
ChEMBL Target Name: Phosphatidylinositol 4-kinase, PI4K
ChEMBL Target Type: PROTEIN FAMILY - Target is a group of closely related proteins
Relationship Type: H - Homologous protein target assigned
Confidence: Multiple homologous protein targets may be assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
100.1	Ki	=	100100	nM	Outside typical range
21.2	Ki	=	21200	nM
4.1	Ki	=	4100	nM
5	Ki	=	5000	nM
5	Ki	=	5000	nM
35.8	Ki	=	35800	nM
10.3	Ki	=	10300	nM
89.5	Ki	=	89500	nM
9	Ki	=	9000	nM
56.8	Ki	=	56800	nM
11	Ki	=	11000	nM
6	Ki	=	6000	nM
15.2	Ki	=	15200	nM
28.2	Ki	=	28200	nM
25.5	Ki	=	25500	nM
99.9	Ki	=	99900	nM
235.4	Ki	=	235400	nM	Outside typical range
150.2	Ki	=	150200	nM	Outside typical range
91.7	Ki	=	91700	nM
85.8	Ki	=	85800	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Epidermal growth factor receptor

External ID: CHEMBL677832

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1997
Volume: 40
Issue: 22
First Page: 3601
Last Page: 3616
DOI: 10.1021/jm970124v

Target ChEMBL ID: CHEMBL203
ChEMBL Target Name: Epidermal growth factor receptor erbB1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
27	IC50	=	27000	nM
2.71	IC50	=	2710	nM
0.005	IC50	=	5	nM
0.096	IC50	=	96	nM
0.008	IC50	=	8	nM
0.026	IC50	=	26	nM
0.058	IC50	=	58	nM
0.8	IC50	=	800	nM
0.007	IC50	=	7	nM
0.029	IC50	=	29	nM
0.002	IC50	=	2	nM
0.33	IC50	=	330	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL826037

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1991
Volume: 34
Issue: 9
First Page: 2877
Last Page: 2882
DOI: 10.1021/jm00113a029

Standard Type	Standard Relation	Standard Value
k'	=	1.66
k'	=	1.29
k'	=	0.21
k'	=	0.56
k'	=	0.11
k'	=	0.39
k'	=	0.22
k'	=	0.04

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Adenosine receptor A2a

External ID: CHEMBL643571

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1991
Volume: 34
Issue: 9
First Page: 2877
Last Page: 2882
DOI: 10.1021/jm00113a029

Target ChEMBL ID: CHEMBL2094117
ChEMBL Target Name: Adenosine A2 receptor
ChEMBL Target Type: PROTEIN FAMILY - Target is a group of closely related proteins
Relationship Type: H - Homologous protein target assigned
Confidence: Multiple homologous protein targets may be assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
11	Ki	=	11000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Adenosine receptor A2a

External ID: CHEMBL648805

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1991
Volume: 34
Issue: 9
First Page: 2877
Last Page: 2882
DOI: 10.1021/jm00113a029

Target ChEMBL ID: CHEMBL2094117
ChEMBL Target Name: Adenosine A2 receptor
ChEMBL Target Type: PROTEIN FAMILY - Target is a group of closely related proteins
Relationship Type: H - Homologous protein target assigned
Confidence: Multiple homologous protein targets may be assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
38	Ki	=	38000	nM
8.2	Ki	=	8200	nM
15	Ki	=	15000	nM
8.8	Ki	=	8800	nM
47	Ki	=	47000	nM
19	Ki	=	19000	nM
31	Ki	=	31000	nM
111	Ki	=	111000	nM	Outside typical range
15	Ki	=	15000	nM
46	Ki	=	46000	nM

20145-09-9 靶点实验数据