HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 4

External ID: CHEMBL4379869

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2020
Volume: 63
Issue: 1
First Page: 321
Last Page: 333
DOI: 10.1021/acs.jmedchem.9b01669

Target ChEMBL ID: CHEMBL3729
ChEMBL Target Name: Carbonic anhydrase IV
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.6753	Ki	=	675.3	nM
1.427	Ki	=	1427	nM
1.228	Ki	=	1228	nM
0.3798	Ki	=	379.8	nM
0.4524	Ki	=	452.4	nM
3.894	Ki	=	3894	nM
0.461	Ki	=	461	nM
3.459	Ki	=	3459	nM
1.945	Ki	=	1945	nM
1.557	Ki	=	1557	nM
0.8536	Ki	=	853.6	nM
0.8966	Ki	=	896.6	nM
0.7086	Ki	=	708.6	nM
1.637	Ki	=	1637	nM
1.748	Ki	=	1748	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 7

External ID: CHEMBL4379870

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2020
Volume: 63
Issue: 1
First Page: 321
Last Page: 333
DOI: 10.1021/acs.jmedchem.9b01669

Target ChEMBL ID: CHEMBL2326
ChEMBL Target Name: Carbonic anhydrase VII
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.4658	Ki	=	465.8	nM
1.899	Ki	=	1899	nM
0.9753	Ki	=	975.3	nM
2.796	Ki	=	2796	nM
2.565	Ki	=	2565	nM
1.282	Ki	=	1282	nM
0.1255	Ki	=	125.5	nM
7.507	Ki	=	7507	nM
1.364	Ki	=	1364	nM
0.4678	Ki	=	467.8	nM
0.6203	Ki	=	620.3	nM
0.956	Ki	=	956	nM
0.4355	Ki	=	435.5	nM
0.6909	Ki	=	690.9	nM
1.178	Ki	=	1178	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 9

External ID: CHEMBL4379871

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2020
Volume: 63
Issue: 1
First Page: 321
Last Page: 333
DOI: 10.1021/acs.jmedchem.9b01669

Target ChEMBL ID: CHEMBL3594
ChEMBL Target Name: Carbonic anhydrase IX
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.0787	Ki	=	78.7	nM
0.3676	Ki	=	367.6	nM
0.0639	Ki	=	63.9	nM
0.0912	Ki	=	91.2	nM
0.0881	Ki	=	88.1	nM
0.2734	Ki	=	273.4	nM
0.0584	Ki	=	58.4	nM
0.1395	Ki	=	139.5	nM
0.0358	Ki	=	35.8	nM
0.031	Ki	=	31	nM
0.0733	Ki	=	73.3	nM
0.0458	Ki	=	45.8	nM
0.0191	Ki	=	19.1	nM
0.0258	Ki	=	25.8	nM
0.0569	Ki	=	56.9	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 12

External ID: CHEMBL4379872

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2020
Volume: 63
Issue: 1
First Page: 321
Last Page: 333
DOI: 10.1021/acs.jmedchem.9b01669

Target ChEMBL ID: CHEMBL3242
ChEMBL Target Name: Carbonic anhydrase XII
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.0531	Ki	=	53.1	nM
0.4587	Ki	=	458.7	nM
0.0693	Ki	=	69.3	nM
0.027	Ki	=	27	nM
0.0346	Ki	=	34.6	nM
0.2472	Ki	=	247.2	nM
0.0427	Ki	=	42.7	nM
0.1815	Ki	=	181.5	nM
0.0645	Ki	=	64.5	nM
0.0966	Ki	=	96.6	nM
0.0758	Ki	=	75.8	nM
0.0743	Ki	=	74.3	nM
0.0249	Ki	=	24.9	nM
0.0383	Ki	=	38.3	nM
0.0708	Ki	=	70.8	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4379873

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2020
Volume: 63
Issue: 1
First Page: 321
Last Page: 333
DOI: 10.1021/acs.jmedchem.9b01669

Standard Type	Standard Relation	Standard Value
Ratio Ki	=	0.8

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4379874

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2020
Volume: 63
Issue: 1
First Page: 321
Last Page: 333
DOI: 10.1021/acs.jmedchem.9b01669

Standard Type	Standard Relation	Standard Value
Ratio Ki	=	21.3
Ratio Ki	=	1.9
Ratio Ki	=	2.3
Ratio Ki	=	2.3
Ratio Ki	=	2.3
Ratio Ki	=	2.3
Ratio Ki	=	2.3
Ratio Ki	=	2.3
Ratio Ki	=	2.3
Ratio Ki	=	2.3
Ratio Ki	=	2.3
Ratio Ki	=	2.3
Ratio Ki	=	2.3
Ratio Ki	=	2.3
Ratio Ki	=	2.3

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4379875

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2020
Volume: 63
Issue: 1
First Page: 321
Last Page: 333
DOI: 10.1021/acs.jmedchem.9b01669

Standard Type	Standard Relation	Standard Value
Ratio Ki	=	213.3
Ratio Ki	=	2.8
Ratio Ki	=	2.1
Ratio Ki	=	2.1
Ratio Ki	=	437.1
Ratio Ki	=	2.1
Ratio Ki	=	2.1
Ratio Ki	=	2.1
Ratio Ki	=	2.1
Ratio Ki	=	2.1
Ratio Ki	=	2.1
Ratio Ki	=	2.1
Ratio Ki	=	2.1
Ratio Ki	=	2.1
Ratio Ki	=	2.1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4379876

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2020
Volume: 63
Issue: 1
First Page: 321
Last Page: 333
DOI: 10.1021/acs.jmedchem.9b01669

Standard Type	Standard Relation	Standard Value
Ratio Ki	>	645.2

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 1

External ID: CHEMBL4379867

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2020
Volume: 63
Issue: 1
First Page: 321
Last Page: 333
DOI: 10.1021/acs.jmedchem.9b01669

Target ChEMBL ID: CHEMBL261
ChEMBL Target Name: Carbonic anhydrase I
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.866	Ki	=	866	nM
2.541	Ki	=	2541	nM
0.9687	Ki	=	968.7	nM
5.783	Ki	=	5783	nM
1.894	Ki	=	1894	nM
6.857	Ki	=	6857	nM
0.5467	Ki	=	546.7	nM
3.406	Ki	=	3406	nM
3.809	Ki	=	3809	nM
4.403	Ki	=	4403	nM
2.324	Ki	=	2324	nM
1.066	Ki	=	1066	nM
1.289	Ki	=	1289	nM
1.274	Ki	=	1274	nM
1.864	Ki	=	1864	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 2

External ID: CHEMBL4379868

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2020
Volume: 63
Issue: 1
First Page: 321
Last Page: 333
DOI: 10.1021/acs.jmedchem.9b01669

Target ChEMBL ID: CHEMBL205
ChEMBL Target Name: Carbonic anhydrase II
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.1503	Ki	=	150.3	nM
2.192	Ki	=	2192	nM
0.1438	Ki	=	143.8	nM
2.445	Ki	=	2445	nM
3.024	Ki	=	3024	nM
1.06	Ki	=	1060	nM
0.1401	Ki	=	140.1	nM
0.8531	Ki	=	853.1	nM
1.922	Ki	=	1922	nM
2.362	Ki	=	2362	nM
0.5269	Ki	=	526.9	nM
0.8717	Ki	=	871.7	nM
0.5336	Ki	=	533.6	nM
0.7635	Ki	=	763.5	nM
1.141	Ki	=	1141	nM

201224-76-2 靶点实验数据