HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：UDP-glucose 6-dehydrogenase

External ID: CHEMBL4316674

Protocol: N/A

Comment: Journal: MedChemComm
Year: 2019
Volume: 10
Issue: 1
First Page: 169
Last Page: 179
DOI: 10.1039/C8MD00463C

Target ChEMBL ID: CHEMBL4523146
ChEMBL Target Name: UDP-glucose 6-dehydrogenase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Units	Activity Comment
Inhibition	%	Active
Inhibition	%	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：UDP-glucose 6-dehydrogenase

External ID: CHEMBL4316673

Protocol: N/A

Comment: Journal: MedChemComm
Year: 2019
Volume: 10
Issue: 1
First Page: 169
Last Page: 179
DOI: 10.1039/C8MD00463C

Target ChEMBL ID: CHEMBL4523146
ChEMBL Target Name: UDP-glucose 6-dehydrogenase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Units	Activity Comment
Inhibition	%	Active
Inhibition	%	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：UDP-glucose 6-dehydrogenase

External ID: CHEMBL4316672

Protocol: N/A

Comment: Journal: MedChemComm
Year: 2019
Volume: 10
Issue: 1
First Page: 169
Last Page: 179
DOI: 10.1039/C8MD00463C

Target ChEMBL ID: CHEMBL4523146
ChEMBL Target Name: UDP-glucose 6-dehydrogenase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	42	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：UDP-glucose 6-dehydrogenase

External ID: CHEMBL4316671

Protocol: N/A

Comment: Journal: MedChemComm
Year: 2019
Volume: 10
Issue: 1
First Page: 169
Last Page: 179
DOI: 10.1039/C8MD00463C

Target ChEMBL ID: CHEMBL4523146
ChEMBL Target Name: UDP-glucose 6-dehydrogenase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	86	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：UDP-glucose 6-dehydrogenase

External ID: CHEMBL4316670

Protocol: N/A

Comment: Journal: MedChemComm
Year: 2019
Volume: 10
Issue: 1
First Page: 169
Last Page: 179
DOI: 10.1039/C8MD00463C

Target ChEMBL ID: CHEMBL4523146
ChEMBL Target Name: UDP-glucose 6-dehydrogenase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	81	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：UDP-glucose 6-dehydrogenase

External ID: CHEMBL4316669

Protocol: N/A

Comment: Journal: MedChemComm
Year: 2019
Volume: 10
Issue: 1
First Page: 169
Last Page: 179
DOI: 10.1039/C8MD00463C

Target ChEMBL ID: CHEMBL4523146
ChEMBL Target Name: UDP-glucose 6-dehydrogenase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	31	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：UDP-glucose 6-dehydrogenase

External ID: CHEMBL4316668

Protocol: N/A

Comment: Journal: MedChemComm
Year: 2019
Volume: 10
Issue: 1
First Page: 169
Last Page: 179
DOI: 10.1039/C8MD00463C

Target ChEMBL ID: CHEMBL4523146
ChEMBL Target Name: UDP-glucose 6-dehydrogenase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	76	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：UDP-glucose 6-dehydrogenase

External ID: CHEMBL4316667

Protocol: N/A

Comment: Journal: MedChemComm
Year: 2019
Volume: 10
Issue: 1
First Page: 169
Last Page: 179
DOI: 10.1039/C8MD00463C

Target ChEMBL ID: CHEMBL4523146
ChEMBL Target Name: UDP-glucose 6-dehydrogenase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	71	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：UDP-glucose 6-dehydrogenase

External ID: CHEMBL4316681

Protocol: N/A

Comment: Journal: MedChemComm
Year: 2019
Volume: 10
Issue: 1
First Page: 169
Last Page: 179
DOI: 10.1039/C8MD00463C

Target ChEMBL ID: CHEMBL4523146
ChEMBL Target Name: UDP-glucose 6-dehydrogenase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Units	Activity Comment
Inhibition	%	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：UDP-glucose 6-dehydrogenase

External ID: CHEMBL4316680

Protocol: N/A

Comment: Journal: MedChemComm
Year: 2019
Volume: 10
Issue: 1
First Page: 169
Last Page: 179
DOI: 10.1039/C8MD00463C

Target ChEMBL ID: CHEMBL4523146
ChEMBL Target Name: UDP-glucose 6-dehydrogenase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Units	Activity Comment
Inhibition	%	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：UDP-glucuronosyltransferase 1A1

External ID: CHEMBL4316679

Protocol: N/A

Comment: Journal: MedChemComm
Year: 2019
Volume: 10
Issue: 1
First Page: 169
Last Page: 179
DOI: 10.1039/C8MD00463C

Target ChEMBL ID: CHEMBL4523339
ChEMBL Target Name: UDP-glucuronosyltransferase 1A1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Units	Activity Comment
Inhibition	%	Not Active
Inhibition	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：UDP-glucuronosyltransferase 1A1

External ID: CHEMBL4316678

Protocol: N/A

Comment: Journal: MedChemComm
Year: 2019
Volume: 10
Issue: 1
First Page: 169
Last Page: 179
DOI: 10.1039/C8MD00463C

Target ChEMBL ID: CHEMBL4523339
ChEMBL Target Name: UDP-glucuronosyltransferase 1A1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Units	Activity Comment
Inhibition	%	Not Active
Inhibition	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4373889

Protocol: N/A

Comment: Journal: MedChemComm
Year: 2019
Volume: 10
Issue: 5
First Page: 717
Last Page: 725
DOI: 10.1039/C9MD00010K

Standard Type	Standard Units	Activity Comment
Inhibition	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：UDP-glucuronosyltransferase 1A1

External ID: CHEMBL4316677

Protocol: N/A

Comment: Journal: MedChemComm
Year: 2019
Volume: 10
Issue: 1
First Page: 169
Last Page: 179
DOI: 10.1039/C8MD00463C

Target ChEMBL ID: CHEMBL4523339
ChEMBL Target Name: UDP-glucuronosyltransferase 1A1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Units	Activity Comment
Inhibition	%	Not Active
Inhibition	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4373891

Protocol: N/A

Comment: Journal: MedChemComm
Year: 2019
Volume: 10
Issue: 5
First Page: 717
Last Page: 725
DOI: 10.1039/C9MD00010K

Standard Type	Standard Units	Activity Comment
Inhibition	%	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：UDP-glucose 6-dehydrogenase

External ID: CHEMBL4316675

Protocol: N/A

Comment: Journal: MedChemComm
Year: 2019
Volume: 10
Issue: 1
First Page: 169
Last Page: 179
DOI: 10.1039/C8MD00463C

Target ChEMBL ID: CHEMBL4523146
ChEMBL Target Name: UDP-glucose 6-dehydrogenase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Units	Activity Comment
Inhibition	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4373845

Protocol: N/A

Comment: Journal: MedChemComm
Year: 2019
Volume: 10
Issue: 5
First Page: 717
Last Page: 725
DOI: 10.1039/C9MD00010K

Standard Type	Standard Units	Activity Comment
Inhibition	%	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4373846

Protocol: N/A

Comment: Journal: MedChemComm
Year: 2019
Volume: 10
Issue: 5
First Page: 717
Last Page: 725
DOI: 10.1039/C9MD00010K

Standard Type	Standard Units	Activity Comment
Inhibition	%	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：REH

External ID: CHEMBL4316663

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: MedChemComm
Year: 2019
Volume: 10
Issue: 1
First Page: 169
Last Page: 179
DOI: 10.1039/C8MD00463C

Target ChEMBL ID: CHEMBL2366320
ChEMBL Target Name: REH
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
10	IC50	>	10000	nM
3.95	IC50	=	3950	nM
9.91	IC50	=	9910	nM
9.54	IC50	=	9540	nM
4.71	IC50	=	4710	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：UDP-glucose 6-dehydrogenase

External ID: CHEMBL4316662

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: MedChemComm
Year: 2019
Volume: 10
Issue: 1
First Page: 169
Last Page: 179
DOI: 10.1039/C8MD00463C

Target ChEMBL ID: CHEMBL4523146
ChEMBL Target Name: UDP-glucose 6-dehydrogenase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
163	Ki	=	163000	nM	Outside typical range
14	Ki	=	14000	nM
192	Ki	=	192000	nM	Outside typical range
215	Ki	=	215000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4373842

Protocol: N/A

Comment: Journal: MedChemComm
Year: 2019
Volume: 10
Issue: 5
First Page: 717
Last Page: 725
DOI: 10.1039/C9MD00010K

Standard Type	Standard Units	Activity Comment
Inhibition	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4373843

Protocol: N/A

Comment: Journal: MedChemComm
Year: 2019
Volume: 10
Issue: 5
First Page: 717
Last Page: 725
DOI: 10.1039/C9MD00010K

Standard Type	Standard Units	Activity Comment
Inhibition	%	Not Active

2002-60-0 靶点实验数据