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199331-53-8 靶点实验数据

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Tyrosine-protein phosphatase non-receptor type 1
External ID: CHEMBL4035961
Protocol: N/A
Comment: Journal: Bioorg Med Chem
Year: 2017
Volume: 25
Issue: 14
First Page: 3706
Last Page: 3713
DOI: 10.1016/j.bmc.2017.05.009

Target ChEMBL ID: CHEMBL335
ChEMBL Target Name: Protein-tyrosine phosphatase 1B
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned
Standard TypeStandard RelationStandard ValueStandard Units
Inhibition=29%
Inhibition=43%
Inhibition=28%
Inhibition=55%
Inhibition=48%
Inhibition=18%
Inhibition=20%
Inhibition=75%
Inhibition=18%
Inhibition=98%
Inhibition=33%
Inhibition=15%
Inhibition=19%
Inhibition=79%
Inhibition=73%
Inhibition=47%
Inhibition=36%
Inhibition=46%
Inhibition=94%
Inhibition=52%
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:N/A
External ID: CHEMBL4035959
Protocol: N/A
Comment: Journal: Bioorg Med Chem
Year: 2017
Volume: 25
Issue: 14
First Page: 3706
Last Page: 3713
DOI: 10.1016/j.bmc.2017.05.009
Standard TypeStandard RelationStandard ValueStandard Units
Inhibition=14%
Inhibition=22%
Inhibition=0%
Inhibition=0%
Inhibition=6%
Inhibition=56%
Inhibition=9%
Inhibition=0%
Inhibition=3%
Inhibition=25%
Inhibition=3%
Inhibition=73%
Inhibition=11%
Inhibition=41%
Inhibition=0%
Inhibition=4%
Inhibition=19%
Inhibition=34%
Inhibition=3%
Inhibition=8%
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:RAW264.7
External ID: CHEMBL4035957
Protocol: N/A
Comment: Journal: Bioorg Med Chem
Year: 2017
Volume: 25
Issue: 14
First Page: 3706
Last Page: 3713
DOI: 10.1016/j.bmc.2017.05.009

Target ChEMBL ID: CHEMBL612557
ChEMBL Target Name: RAW264.7
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular
Standard TypeStandard RelationStandard ValueStandard Units
Inhibition=13%
Inhibition=6%
Inhibition=0%
Inhibition=5%
Inhibition=14%
Inhibition=39%
Inhibition=1%
Inhibition=26%
Inhibition=58%
Inhibition=16%
Inhibition=0%
Inhibition=22%
Inhibition=0%
Inhibition=19%
Inhibition=0%
Inhibition=1%
Inhibition=0%
Inhibition=14%
Inhibition=0%
Inhibition=3%
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Nuclear factor erythroid 2-related factor 2
External ID: CHEMBL4046717
Protocol: N/A
Comment: Journal: Bioorg Med Chem
Year: 2017
Volume: 25
Issue: 20
First Page: 5522
Last Page: 5530
DOI: 10.1016/j.bmc.2017.08.018

Target ChEMBL ID: CHEMBL1075094
ChEMBL Target Name: Nuclear factor erythroid 2-related factor 2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned
Standard TypeStandard RelationStandard Value
FC=1.2
FC=1.23
FC=4.67
FC=4.07
FC=1.42
FC=4.09
FC=1.17
FC=1.87
FC=2.65
FC=1.08
FC=1.49
FC=2.17
FC=1.91
FC=2.28
FC=1.97
FC=1.41
FC=1.34
FC=1.91
FC=1.21
FC=1.12
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:HepG2
External ID: CHEMBL4035954
Protocol: N/A
Comment: Journal: Bioorg Med Chem
Year: 2017
Volume: 25
Issue: 14
First Page: 3706
Last Page: 3713
DOI: 10.1016/j.bmc.2017.05.009

Target ChEMBL ID: CHEMBL395
ChEMBL Target Name: HepG2
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular
Standard TypeStandard RelationStandard ValueStandard Units
GI=29%
GI=28%
GI=3%
GI=18%
GI=0%
GI=14%
GI=22%
GI=6%
GI=21%
GI=2%
GI=0%
GI=5%
GI=6%
GI=40%
GI=39%
GI=0%
GI=13%
GI=24%
GI=7%
GI=0%
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:MCF7
External ID: CHEMBL4035952
Protocol: N/A
Comment: Journal: Bioorg Med Chem
Year: 2017
Volume: 25
Issue: 14
First Page: 3706
Last Page: 3713
DOI: 10.1016/j.bmc.2017.05.009

Target ChEMBL ID: CHEMBL387
ChEMBL Target Name: MCF7
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular
Standard TypeStandard RelationStandard ValueStandard Units
GI=6%
GI=21%
GI=0%
GI=11%
GI=0%
GI=10%
GI=26%
GI=0%
GI=0%
GI=2%
GI=2%
GI=0%
GI=17%
GI=3%
GI=16%
GI=1%
GI=27%
GI=86%
GI=73%
GI=15%
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:SW480
External ID: CHEMBL4035953
Protocol: N/A
Comment: Journal: Bioorg Med Chem
Year: 2017
Volume: 25
Issue: 14
First Page: 3706
Last Page: 3713
DOI: 10.1016/j.bmc.2017.05.009

Target ChEMBL ID: CHEMBL612544
ChEMBL Target Name: SW480
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular
Standard TypeStandard RelationStandard ValueStandard Units
GI=21%
GI=28%
GI=43%
GI=22%
GI=16%
GI=7%
GI=25%
GI=24%
GI=19%
GI=12%
GI=4%
GI=31%
GI=34%
GI=13%
GI=20%
GI=13%
GI=9%
GI=81%
GI=58%
GI=18%
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Tyrosine-protein phosphatase non-receptor type 1
External ID: CHEMBL4035962
Protocol: N/A
Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem
Year: 2017
Volume: 25
Issue: 14
First Page: 3706
Last Page: 3713
DOI: 10.1016/j.bmc.2017.05.009

Target ChEMBL ID: CHEMBL335
ChEMBL Target Name: Protein-tyrosine phosphatase 1B
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned
PubChem Standard ValueStandard TypeStandard RelationStandard ValueStandard Units
0.31IC50=310nM
0.45IC50=450nM
4.5IC50=4500nM
0.84IC50=840nM
1.48IC50=1480nM
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Polyphenol oxidase 4
External ID: CHEMBL4035963
Protocol: N/A
Comment: Journal: Bioorg Med Chem
Year: 2017
Volume: 25
Issue: 14
First Page: 3706
Last Page: 3713
DOI: 10.1016/j.bmc.2017.05.009

Target ChEMBL ID: CHEMBL6066154
ChEMBL Target Name: Mushroom tyrosinase
ChEMBL Target Type: PROTEIN FAMILY - Target is a group of closely related proteins
Relationship Type: D - Direct protein target assigned
Confidence: Multiple direct protein targets may be assigned
Standard TypeStandard RelationStandard ValueStandard Units
Inhibition=2%
Inhibition=10%
Inhibition=9%
Inhibition=11%
Inhibition=12%
Inhibition=1%
Inhibition=5%
Inhibition=16%
Inhibition=2%
Inhibition=16%
Inhibition=10%
Inhibition=14%
Inhibition=15%
Inhibition=2%
Inhibition=14%
Inhibition=11%
Inhibition=2%
Inhibition=5%
Inhibition=3%
Inhibition=8%